Osamu Nureki

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Challenges of Structural Life Science

Osamu Nureki, 2012 .

Figure 5, [Schematic drawing of the “double-sieve” concept for amino-acid selection by ValRS.].

Shigeyuki Yokoyama, Osamu Nureki, 2013 .

Structure-based development of genome-editing tools of CRISPR-Cas towards medical applications

Osamu Nureki, Mari Yamada, Hisato Hirano, 2017 .

Data processing pipeline for serial femtosecond crystallography at SACLA

Makina Yabashi, Takanori Nakane, So Iwata, 2016, Journal of applied crystallography.

Engineered PAM-flexible FnCas9 variants for robust and specific genome editing and diagnostics

Debojyoti Chakraborty, Souvik Maiti, Osamu Nureki, 2021 .

Structural Basis of RNA-Dependent Recruitment of Glutamine to the Genetic Code

Liang Feng, Kelly Sheppard, Osamu Nureki, 2006, Science.

Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus.

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

A three-dimensional movie of structural changes in bacteriorhodopsin

Takashi Kameshima, Gebhard F. X. Schertler, Makina Yabashi, 2016, Science.

An enzyme with a deep trefoil knot for the active-site architecture.

Shigeyuki Yokoyama, Osamu Nureki, Seiki Kuramitsu, 2002, Acta crystallographica. Section D, Biological crystallography.

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains

Jae-Hoon Kim, Kazuki Saito, Shigeyuki Yokoyama, 2002, Cell.

Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors.

Yoshiki Tanaka, Hiroaki Suga, Osamu Nureki, 2018, Methods in molecular biology.

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.

Takanori Nakane, Feng Zhang, Jonathan S Gootenberg, 2017, Molecular cell.

Engineered Cpf1 variants with altered PAM specificities increase genome targeting range

Feng Zhang, Osamu Nureki, Nicola Crosetto, 2017, Nature Biotechnology.

Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

Takashi Kameshima, Makina Yabashi, Changyong Song, 2015, Acta crystallographica. Section D, Biological crystallography.

Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate

Kunio Hirata, Makina Yabashi, Go Ueno, 2017, Nature Communications.

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Kuniaki Saito, Naoki Matsumoto, Tomohiro Nishizawa, 2012, Nature.

Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase.

Shigeyuki Yokoyama, Osamu Nureki, O. Nureki, 2003, RNA.

Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.

Tetsuo Nagano, Hirotatsu Kojima, Osamu Nureki, 2013, ACS chemical biology.

Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL

Takashi Kameshima, Tetsuya Ishikawa, Takanori Nakane, 2017, Nature.

ATP binding by glutamyl‐tRNA synthetase is switched to the productive mode by tRNA binding

Shigeyuki Yokoyama, Osamu Nureki, O. Nureki, 2003, The EMBO journal.

Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9.

Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, 2016, Molecular cell.

Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation

Dieter Söll, Nobuhisa Watanabe, Kelly Sheppard, 2010, Nucleic acids research.

Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form.

Shigeyuki Yokoyama, Osamu Nureki, Ryuichiro Ishitani, 2002, Molecular cell.

Crystal structures of leucyl/phenylalanyl‐tRNA‐protein transferase and its complex with an aminoacyl‐tRNA analog

Takuya Ueda, Osamu Nureki, Yoshihiro Shimizu, 2006, The EMBO journal.

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

Yoshiki Tanaka, Hiroaki Suga, Osamu Nureki, 2013, Nature.

Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4†

Osamu Nureki, Ryuichiro Ishitani, Tsutomu Suzuki, 2009, Nucleic acids research.

Mutational separation of two pathways for editing by a class I tRNA synthetase.

Paul Schimmel, Shigeyuki Yokoyama, Osamu Nureki, 2002, Molecular cell.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Takanori Nakane, Tomohiro Nishizawa, Osamu Nureki, 2019, Nature Structural & Molecular Biology.

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

Kazuki Kurimoto, Shigeyuki Yokoyama, Osamu Nureki, 1999, Nature.

Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography

Takashi Kameshima, Tsuyoshi Inoue, Makina Yabashi, 2016, Proceedings of the National Academy of Sciences.

Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase

Shigeyuki Yokoyama, Osamu Nureki, O. Nureki, 2001, Nature Structural Biology.

Activation mechanism of endothelin ETB receptor by endothelin-1

Tomohiro Nishizawa, Kazutoshi Tani, Osamu Nureki, 2016, Nature.

Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases*

Toru Kita, Osamu Nureki, Takeshi Kimura, 2009, The Journal of Biological Chemistry.

Simplification of the genetic code: restricted diversity of genetically encoded amino acids

Daisuke Kiga, Takanori Kigawa, Shigeyuki Yokoyama, 2012, Nucleic acids research.

Structure, dynamics, and function of RNA modification enzymes.

Shigeyuki Yokoyama, Osamu Nureki, Ryuichiro Ishitani, 2008, Current opinion in structural biology.

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

Toshio Ando, Takayuki Uchihashi, Osamu Nureki, 2017, Nature Communications.

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

Shigeyuki Yokoyama, Osamu Nureki, Ryuichiro Ishitani, 2003, Nature Structural Biology.

Structural Basis for Double-Sieve Discrimination of L-Valine from L-Isoleucine and L-Threonine by the Complex of tRNAVal and Valyl-tRNA Synthetase

Shigeyuki Yokoyama, Osamu Nureki, O. Nureki, 2000, Cell.

Engineered Cpf1 variants with altered PAM specificities increase genome targeting range

Feng Zhang, Osamu Nureki, Nicola Crosetto, 2017, Nature Biotechnology.

Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme.

Hiroyuki Hori, Ryohei Ishii, Shigeyuki Yokoyama, 2004, Structure.

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

Junichi Takagi, Hirofumi Ueda, Emiko Mihara, 2016, Scientific Reports.

Structural basis of Sec-independent membrane protein insertion by YidC

Yoshiki Tanaka, Kunio Hirata, Yuji Sugita, 2014, Nature.

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

Kira S. Makarova, Eugene V. Koonin, Yinqing Li, 2016, Cell.

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Feng Zhang, Silvana Konermann, Osamu Nureki, 2014, Cell.

Crystal Structure of Staphylococcus aureus Cas9

Yinqing Li, Feng Zhang, Osamu Nureki, 2015, Cell.

Crystallization and preliminary X-ray analysis of the tRNA thiolation enzyme MnmA from Escherichia coli complexed with tRNAGlu

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2006 .

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies

Dieter Söll, Shigeyuki Yokoyama, Osamu Nureki, 2002, Nature Structural Biology.

Structure and Engineering of Francisella novicida Cas9

Takanori Nakane, Feng Zhang, Osamu Nureki, 2016, Cell.

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

Tomohiro Nishizawa, Keitaro Yamashita, Osamu Nureki, 2019, Science.

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nozomu Yachie, Hiroyuki Aburatani, Feng Zhang, 2018, Science.

Snapshots of tRNA sulphuration via an adenylated intermediate

Yoshiho Ikeuchi, Osamu Nureki, Tsutomu Suzuki, 2006, Nature.