JoAnne L. Flynn

发表

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

Timothy Wessler, Denise E. Kirschner, Jennifer J. Linderman, 2019, bioRxiv.

Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome

Simeone Marino, Chang Gong, Shawn Mankad, 2016, PLoS Comput. Biol..

Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue

John Chan, Simeone Marino, Denise E. Kirschner, 2007, PLoS Comput. Biol..

Understanding Latent Tuberculosis: A Moving Target

JoAnne L. Flynn, Philana Ling Lin, J. Flynn, 2010, The Journal of Immunology.

TNF Influences Chemokine Expression of Macrophages In Vitro and That of CD11b+ Cells In Vivo during Mycobacterium tuberculosis Infection1

John Chan, JoAnne L. Flynn, Philana Ling Lin, 2004, The Journal of Immunology.

Fate of Mycobacterium tuberculosis within Murine Dendritic Cells

JoAnne L. Flynn, J. Flynn, N. Serbina, 2001, Infection and Immunity.

Tuberculosis: Latency and Reactivation

John Chan, JoAnne L. Flynn, J. Flynn, 2001, Infection and Immunity.

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

JoAnne L. Flynn, Clifton E. Barry, Philana Ling Lin, 2013, Antimicrobial Agents and Chemotherapy.

Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection

Simeone Marino, Denise E. Kirschner, Jennifer J. Linderman, 2015, The Journal of Immunology.

Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection1

J. Christian J. Ray, Denise E. Kirschner, JoAnne L. Flynn, 2009, The Journal of Immunology.

Tuberculosis: What We Don’t Know Can, and Does, Hurt Us

David G. Russell, JoAnne L. Flynn, Clifton E. Barry, 2010, Science.

Dendritic Cell Trafficking and Antigen Presentation in the Human Immune Response to Mycobacterium tuberculosis 1

Simeone Marino, Denise E. Kirschner, JoAnne L. Flynn, 2004, The Journal of Immunology.

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

Simeone Marino, Denise E. Kirschner, JoAnne L. Flynn, 2015, PLoS pathogens.

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

JoAnne L. Flynn, Philana Ling Lin, A. Myers, 2009, Infection and Immunity.

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

James A. Raleigh, JoAnne L. Flynn, Clifton E. Barry, 2008, Infection and Immunity.

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

Jin Hee Kim, Simeone Marino, Denise E. Kirschner, 2013, The Journal of Immunology.

Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque

Rachel Brower-Sinning, Panayiotis V. Benos, Shaun Mahony, 2011, PloS one.

Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing

JoAnne L. Flynn, Philana Ling Lin, Thomas Ioerger, 2014 .

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load

Timothy J. Sturgeon, JoAnne L. Flynn, Philana Ling Lin, 2010, PloS one.

Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

JoAnne L. Flynn, A. Myers, J. Flynn, 2003, Infection and Immunity.

Latent tuberculosis: what the host “sees”?

Hannah P. Gideon, JoAnne L. Flynn, J. Flynn, 2011, Immunologic research.

Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

Simeone Marino, Denise E. Kirschner, Jennifer J. Linderman, 2014, Infection and Immunity.

New insights into mathematical modeling of the immune system

Shlomo Ta'asan, Denise E. Kirschner, Penelope A. Morel, 2006, Immunologic research.

Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

John Chan, JoAnne L. Flynn, J. Flynn, 2000, The Journal of experimental medicine.

SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues

Fabian J Theis, Alison Yu, Alex K. Shalek, 2020, SSRN Electronic Journal.

A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis

Simeone Marino, Mohammad Fallahi-Sichani, Denise E. Kirschner, 2013 .

Granzyme B‐expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis‐infected cynomolgus macaques

JoAnne L. Flynn, Laura E. Via, J. Flynn, 2015, Cellular microbiology.

Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection

Denise E. Kirschner, JoAnne L. Flynn, D. Kirschner, 2005 .

Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology

JoAnne L. Flynn, J. Flynn, C. Scanga, 2001, Infection and Immunity.