Jonathan L Chen

发表

Target-Directed Approaches for Screening Small Molecules against RNA Targets

Hafeez S Haniff, Laurent Knerr, Jonathan L Chen, 2020, SLAS discovery : advancing life sciences R & D.

Testing the Nearest Neighbor Model for Canonical RNA Base Pairs: Revision of GU Parameters

Jonathan L Chen, D. Turner, Ilyas Yildirim, 2012, Biochemistry.

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2018, Chemical reviews.

Nuclear Magnetic Resonance-Assisted Prediction of Secondary Structure for RNA: Incorporation of Direction-Dependent Chemical Shift Constraints

Jonathan L Chen, D. Turner, D. Mathews, 2015, Biochemistry.

RNA Secondary Structure Determination by NMR.

Jonathan L Chen, Douglas H Turner, Stanislav Bellaousov, 2016, Methods in molecular biology.

Study of structures, energetics, IR spectra and 13C and 1H NMR chemical shifts of the conformations of isopropyl cation by ab initio calculations

Jonathan L Chen, G. Olah, G. Prakash, 2011 .

Ab initio/GIAO-CCSD(T) study of the trimethyl- and dimethylsilicenium ions: structures, (29)Si, (13)C, and (1)H NMR chemical shifts, and IR spectra.

Jonathan L Chen, Golam Rasul, G. Olah, 2010, The journal of physical chemistry. A.

Biophysical Analysis of Influenza A Virus RNA Promoter at Physiological Temperatures*

Jonathan L Chen, D. Turner, D. Mathews, 2011, The Journal of Biological Chemistry.

Improving RNA nearest neighbor parameters for helices by going beyond the two-state model

Jonathan L Chen, D. Turner, D. Mathews, 2018, Nucleic acids research.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2019, PloS one.

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, PloS one.

Scans of the MYC mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expression

Jonathan L Chen, Jessica L. Childs-Disney, Collin A O'Leary, 2019, bioRxiv.

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Jonathan L Chen, Ilyas Yildirim, M. Disney, 2017, Biochemistry.

Structural Features of a 3′ Splice Site in Influenza A

Jonathan L Chen, D. Turner, S. Kennedy, 2015, Biochemistry.

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.

Jonathan L Chen, Jessica L. Childs-Disney, G. Rumbaugh, 2020, Journal of the American Chemical Society.

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Hafeez S Haniff, Jonathan L Chen, Collin A O'Leary, 2020, ACS central science.

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

Jonathan L Chen, Ilyas Yildirim, M. Disney, 2020, bioRxiv.

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.

Jonathan L Chen, L. Petrucelli, Ilyas Yildirim, 2020, ACS chemical biology.

Small molecule targeting of RNA structures in neurological disorders

Jonathan L Chen, M. Disney, Alicia J. Angelbello, 2020, Annals of the New York Academy of Sciences.

An in silico map of the SARS-CoV-2 RNA Structurome

Hafeez S Haniff, Jonathan L Chen, Walter N. Moss, 2020, bioRxiv.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, bioRxiv.

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways.

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2021, Journal of medicinal chemistry.

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

Eric T. Wang, Jonathan L Chen, Jessica L. Childs-Disney, 2021, Science Translational Medicine.

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

Eric T. Wang, Jonathan L Chen, Walter N. Moss, 2019, Proceedings of the National Academy of Sciences.

Ab initio/DFT/GIAO-CCSD(T) calculational study of the t-butyl cation: comparison of experimental data with structures, energetics, IR vibrational frequencies, and 13C NMR chemical shifts indicating preferred C(s) conformation.

Jonathan L Chen, G. Olah, G. Prakash, 2009, The journal of physical chemistry. A.