Christian Wiesmann

发表

Cryo-EM in drug discovery: achievements, limitations and prospects

Claudio Ciferri, Jean-Paul Renaud, Ashwin Chari, 2018, Nature Reviews Drug Discovery.

Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition.

Sachdev S Sidhu, Christian Wiesmann, Frederic A. Fellouse, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Christian Wiesmann, Ping Wu, M. Tessier-Lavigne, 2007, The EMBO journal.

Allosteric inhibition of protein tyrosine phosphatase 1B

Wang Shen, Daniel A Erlanson, Christian Wiesmann, 2004, Nature Structural &Molecular Biology.

Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.

Daniel A Erlanson, Christian Wiesmann, W. Delano, 2002, Journal of medicinal chemistry.

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Somasekar Seshagiri, L. Aravind, Eugene V. Koonin, 2004, Nature.

Comparative Structural Analysis of the Erbin PDZ Domain and the First PDZ Domain of ZO-1

Walter Hunziker, Sachdev S Sidhu, Christian Wiesmann, 2006, Journal of Biological Chemistry.

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.

Andreas Lingel, Thomas M Weiss, Christian Wiesmann, 2009, Structure.

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.

Guy Georges, Elizabeth Blackwood, Christian Wiesmann, 2008, Journal of medicinal chemistry.

Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families*

Walter Hunziker, Sachdev S. Sidhu, Christian Wiesmann, 2006, Journal of Biological Chemistry.

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Ariana Peck, Shiuh-Ming Luoh, Steve Price, 2013, Nature.

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

Franklin Peale, David Kan, Christian Wiesmann, 2009, Science.

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.

Jennafer Dotson, Christian Wiesmann, Jason Drummond, 2009, Journal of medicinal chemistry.

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Charles Eigenbrot, Christian Wiesmann, James A. Wells, 1997, Cell.

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer .

Gary Box, Paul Workman, Christian Wiesmann, 2008, Journal of medicinal chemistry.

Supplemental Data Structure of IL-33 and Its Interaction with the ST 2 and IL-1 RAcP Receptors — Insight into the Heterotrimeric IL-1 Signaling Complexes

Andreas Lingel, Christian Wiesmann, Thomas M. Weiss, 2009 .

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Christian Wiesmann, S. Bass, M. Ultsch, 1999, Nature.

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.

Christian Wiesmann, Pamela Chan, Ping Wu, 2009, The Journal of clinical investigation.

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite*

Jeremy Murray, Christian Wiesmann, Ping Wu, 2012, The Journal of Biological Chemistry.

Crystal structure of the HGF β‐chain in complex with the Sema domain of the Met receptor

Christian Wiesmann, D. Kirchhofer, C. Wiesmann, 2004, The EMBO journal.