David E. Gloriam

发表

Selectivity determinants of GPCR–G-protein binding

M. Madan Babu, Tilman Flock, Alexander S. Hauser, 2017, Nature.

Computer-Aided Discovery of Aromatic l-α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

David E. Gloriam, Vignir Ísberg, Kirsten B. Andersen, 2014, J. Chem. Inf. Model..

Bigger is better in virtual drug screens

David E. Gloriam, 2019, Nature.

GPCRdb: an information system for G protein-coupled receptors

Bas Vroling, Gert Vriend, Alexander S. Hauser, 2015, Nucleic Acids Res..

GPCRdb in 2018: adding GPCR structure models and ligands

Alexander S. Hauser, David E. Gloriam, Andrzej J. Bojarski, 2017, Nucleic Acids Res..

The SMARTCyp cytochrome P450 metabolism prediction server

David E. Gloriam, Lars Olsen, Patrik Rydberg, 2010, Bioinform..

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

David E. Gloriam, Hans Bräuner-Osborne, Kasper Harpsøe, 2016, Bioinform..

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

Neil D. Rawlings, Robert D. Finn, Alex Bateman, 2015, Database J. Biol. Databases Curation.

G Protein- and Agonist-Bound Serotonin 5-HT2A Receptor Model Activated by Steered Molecular Dynamics Simulations

David E. Gloriam, Vignir Ísberg, Flemming Steen Jørgensen, 2011, J. Chem. Inf. Model..

Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

David E. Gloriam, Vignir Ísberg, Patrik Rydberg, 2013, J. Chem. Inf. Model..

GPCRDB: an information system for G protein-coupled receptors

Bas Vroling, Gert Vriend, David E. Gloriam, 2013, Nucleic Acids Res..

GPCRmd uncovers the dynamics of the 3D-GPCRome

Toni Giorgino, Gianni De Fabritiis, David E. Gloriam, 2019, bioRxiv.

The G Protein–Coupled Receptor Subset of the Chicken Genome

David E. Gloriam, Helgi B. Schiöth, Robert Fredriksson, 2006, PLoS Comput. Biol..

GPCRdb in 2021: integrating GPCR sequence, structure and function

György M. Keserü, David E. Gloriam, Mauricio Esguerra, 2020, Nucleic Acids Res..

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.

Andrew Tobin, Peter Kolb, Nina Vardjan, 2020, ACS pharmacology & translational science.

GPCRdb: an information system for G protein-coupled receptors

Bas Vroling, Gert Vriend, Alexander S. Hauser, 2016, Nucleic acids research.

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

Christina Mølck, David E. Gloriam, Hans Bräuner-Osborne, 2014, Neurochemical Research.

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

David E. Gloriam, John D. McCorvy, Bryan L. Roth, 2018, Cell.

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

David E. Gloriam, Hans Bräuner-Osborne, Kasper Harpsøe, 2015, Scientific Reports.

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor

David E. Gloriam, D. Gloriam, H. Bräuner‐Osborne, 2019, Basic & clinical pharmacology & toxicology.

Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation

David E. Gloriam, B. Hudson, G. Milligan, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

David E. Gloriam, Ariana C. Gavin, Ryan T. Strachan, 2019, Cell.

Trends in GPCR drug discovery: new agents, targets and indications

David E. Gloriam, Misty M Attwood, M. Rask-Andersen, 2017, Nature Reviews Drug Discovery.

Editorial overview: New technologies: GPCR drug design and function-exploiting the current (of) structures.

David E. Gloriam, Christofer S Tautermann, David E Gloriam, 2016, Current opinion in pharmacology.

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.

David E. Gloriam, H. Schiöth, D. Gloriam, 2003, Biochemical and biophysical research communications.

A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors.

David E. Gloriam, Stefan Mordalski, Vignir Isberg, 2015, Methods.

3-Substituted 2-phenyl-indoles: privileged structures for medicinal chemistry

David E. Gloriam, D. Gloriam, H. Bräuner‐Osborne, 2013 .

GPCR activation mechanisms across classes and macro/microscales

M. Madan Babu, David E. Gloriam, David Gloriam, 2021, Nature Structural & Molecular Biology.

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

David E. Gloriam, E. Fauman, A. Hauser, 2022, bioRxiv.

Community guidelines for GPCR ligand bias: IUPHAR review 32

David E. Gloriam, Stephen P. H. Alexander, R. Neubig, 2022, British journal of pharmacology.

Novel approaches leading towards peptide GPCR de‐orphanisation

David E. Gloriam, A. Hauser, D. Gloriam, 2019, British journal of pharmacology.

Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils.

David E. Gloriam, D. Gloriam, D. S. Pedersen, 2017, Journal of pharmacological and toxicological methods.

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome

David E. Gloriam, T. Gibson, J. Hoheisel, 2007, Nature Methods.

A Community Standard Format for the Representation of Protein Affinity Reagents*

Peter Woollard, Henning Hermjakob, Zoltán Konthur, 2009, Molecular & Cellular Proteomics.

GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources

David E. Gloriam, G. Keserü, D. Gloriam, 2022, Nucleic Acids Res..

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.

David E. Gloriam, Robert Fredriksson, David E Gloriam, 2006, Genomics.

Critical evaluation of the FANTOM3 non-coding RNA transcripts.

David E. Gloriam, M. S. Almén, H. Schiöth, 2009, Genomics.

Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

David E. Gloriam, M. Babu, N. Vaidehi, 2022, Nature Communications.

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

David E. Gloriam, D. Gloriam, H. Xu, 2022, Molecular cell.

Structural insights into the lipid and ligand regulation of serotonin receptors

David E. Gloriam, Hualiang Jiang, C. Robinson, 2021, Nature.

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

David E. Gloriam, Robert Fredriksson, David E Gloriam, 2004, Genomics.

The G protein database, GproteinDb

David E. Gloriam, G. Keserü, A. Hauser, 2021, Nucleic Acids Res..

GPCRmd uncovers the dynamics of the 3D-GPCRome

Toni Giorgino, Davide Provasi, Gianni De Fabritiis, 2020, Nature Methods.

GPCRmd uncovers the dynamics of the 3D-GPCRome

David E. Gloriam, Johanna K. S. Tiemann, J. C. Gómez-Tamayo, 2020 .

Pharmacogenomics of GPCR Drug Targets

David E. Gloriam, M. Babu, S. Chavali, 2018, Cell.

Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

David E. Gloriam, J. M. Mathiesen, D. Gloriam, 2020, The Journal of Biological Chemistry.

Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform

David E. Gloriam, E. Fauman, A. Hauser, 2020, SSRN Electronic Journal.

Generic GPCR residue numbers - aligning topology maps while minding the gaps.

David E. Gloriam, G. Vriend, R. Stevens, 2015, Trends in pharmacological sciences.

Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists

David E. Gloriam, D. Gloriam, C. Stove, 2023, ACS chemical neuroscience.

Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists

David E. Gloriam, D. Gloriam, C. Stove, 2022, Journal of medicinal chemistry.

Integrating structural and mutagenesis data to elucidate GPCR ligand binding.

David E. Gloriam, Kasper Harpsøe, Vignir Isberg, 2016, Current opinion in pharmacology.

SMARTCyp: A 2D Method for Prediction of Cytochrome P450-Mediated Drug Metabolism.

David E. Gloriam, Lars Olsen, Patrik Rydberg, 2010, ACS medicinal chemistry letters.

Chemogenomics of allosteric binding sites in GPCRs.

David E. Gloriam, D. Gloriam, 2013, Drug discovery today. Technologies.

Pharmacological Characterization and Modeling of the Binding Sites of Novel 1,3-Bis(pyridinylethynyl)benzenes as Metabotropic Glutamate Receptor 5-Selective Negative Allosteric Modulators

Christina Mølck, David E. Gloriam, Hans Bräuner-Osborne, 2012, Molecular Pharmacology.

A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?

Stefan Verhoeven, Márton Vass, David E. Gloriam, 2018, Methods in molecular biology.

Microsoft Word-72803376-file00

David E. Gloriam, J. M. Mathiesen, D. Gloriam, 2012 .

Probing the existence of a metastable binding site at the β2-adrenergic receptor with homobivalent bitopic ligands.

David E. Gloriam, J. M. Mathiesen, D. Gloriam, 2019, Journal of medicinal chemistry.

The G protein-coupled receptor subset of the rat genome

David E. Gloriam, H. Schiöth, R. Fredriksson, 2007, BMC Genomics.

Minimum information about a protein affinity reagent (MIAPAR)

Henning Hermjakob, David Juncker, David E. Gloriam, 2010, Nature Biotechnology.

GPCRdb: an information system for G protein-coupled receptors

David E. Gloriam, A Bairoch, F Campagne, 2015, Nucleic Acids Res..

Combinatorial expression of GPCR isoforms affects signalling and drug responses

David E. Gloriam, M. Babu, G. Ladds, 2020, Nature.

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.

David E. Gloriam, J. Kehler, D. Gloriam, 2017, Journal of medicinal chemistry.

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.

David E. Gloriam, G. V. van Westen, E. Sotelo, 2018, Trends in pharmacological sciences.

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor.

David E. Gloriam, A. Hauser, H. Bräuner‐Osborne, 2024, British journal of pharmacology.

Ligand-directed bias of G protein signaling at the dopamine D2 receptor.

David E. Gloriam, A. Hauser, D. Gloriam, 2021, Cell chemical biology.

The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish.

David E. Gloriam, Robert Fredriksson, John H Postlethwait, 2005, Molecular phylogenetics and evolution.

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation.

David E. Gloriam, D. Gloriam, K. Strømgaard, 2021, Journal of the American Chemical Society.

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors.

David E. Gloriam, D. Gloriam, Xiao-Feng Xiong, 2016, Nature chemistry.

Seven evolutionarily conserved human rhodopsin G protein‐coupled receptors lacking close relatives

David E. Gloriam, H. Schiöth, D. Gloriam, 2003, FEBS letters.

GPCRDB: an information system for G protein-coupled receptors

David E. Gloriam, G. Vriend, D. Gloriam, 2013, Nucleic Acids Res..

Differential GLP-1R binding and activation by peptide and non-peptide agonists

David E. Gloriam, C. Langmead, P. Sexton, 2020, bioRxiv.

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

David E. Gloriam, T. Takeuchi, D. Gloriam, 2021, Molecular brain.

Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2.

David E. Gloriam, D. Gloriam, K. Strømgaard, 2023, Journal of medicinal chemistry.

Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.

David E. Gloriam, D. Gloriam, H. Bräuner‐Osborne, 2015, Journal of medicinal chemistry.

The contribution of atom accessibility to site of metabolism models for cytochromes P450.

David E. Gloriam, Lars Olsen, Patrik Rydberg, 2013, Molecular pharmaceutics.

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.

David E. Gloriam, D. Gloriam, P. Krogsgaard‐Larsen, 2013, Journal of medicinal chemistry.

Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling response

David E. Gloriam, Junmin, M. Babu, 2021 .