J. A. Spicer

发表

The viability of very high data rate modems for a specific HF channel type

S. G. Farquhar, A. P. Noble, J. A. Spicer, 1997 .

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

J. A. Spicer, J. Trapani, J. Trebicka, 2018, Nature Communications.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Daniel F Ortwine, J. A. Spicer, W. Denny, 2007, Journal of medicinal chemistry.

Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors

J. A. Spicer, J. Trapani, K. Gartlan, 2022, ACS pharmacology & translational science.

IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40

J. A. Spicer, Jesse D. Gelles, J. Trapani, 2022, Cellular & Molecular Immunology.

Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo.

J. A. Spicer, W. Denny, J. Trapani, 2020, Journal of medicinal chemistry.

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

J. A. Spicer, W. Denny, J. Trapani, 2017, European journal of medicinal chemistry.

L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors.

J. A. Spicer, W. Denny, K. Huttunen, 2016, International journal of pharmaceutics.

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

J. A. Spicer, J. Trapani, I. Voskoboinik, 2022, Journal of medicinal chemistry.

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

J. A. Spicer, W. Denny, J. Trapani, 2008, Journal of medicinal chemistry.

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.

J. A. Spicer, S. Gamage, W. Denny, 2002, Journal of medicinal chemistry.

Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.

J. A. Spicer, S. Gamage, W. Denny, 2001, Journal of medicinal chemistry.

A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells.

J. A. Spicer, W. Denny, Elena Puris, 2016, Journal of medicinal chemistry.

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

J. A. Spicer, S. Gamage, W. Denny, 1999, Journal of medicinal chemistry.

Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs.

J. A. Spicer, S. Gamage, W. Denny, 2002, Bioorganic & medicinal chemistry.

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.

J. A. Spicer, P. Ellis, W. Denny, 2016, Journal of medicinal chemistry.

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.

J. A. Spicer, W. Denny, J. Trapani, 2012, Bioorganic & medicinal chemistry.

Identification of Conjugated Triene Oxidation Products of .alpha.-Farnesene in Apple Skin

J. A. Spicer, M. Brimble, D. Rowan, 1995 .

Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

J. A. Spicer, S. Gamage, W. Denny, 1999, Anti-cancer drug design.

Oxidation of α-Farnesene

J. A. Spicer, M. Brimble, D. Rowan, 1993 .

Synthesis of Conjugated Trienes and Related Oxidation Products of α-Farnesene

J. A. Spicer, M. Brimble, D. Rowan, 1994 .

Oxidation of α-Farnesene.

J. A. Spicer, M. Brimble, D. Rowan, 1994 .

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs.

J. A. Spicer, W. Denny, D. Pickering, 2016, Molecular pharmaceutics.

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

J. A. Spicer, W. Denny, J. Trapani, 2011, Bioorganic & medicinal chemistry.

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

J. A. Spicer, W. Denny, J. Trapani, 2014, European Journal of Drug Metabolism and Pharmacokinetics.

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

J. A. Spicer, W. Denny, J. Trapani, 2013, Journal of medicinal chemistry.

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

J. A. Spicer, M. Moniatte, V. Heussler, 2011, Cellular microbiology.

Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.

K. Y. Tsang, J. A. Spicer, S. Gamage, 2019, Chemistry, an Asian journal.

New small-molecule inhibitors of mitogen-activated protein kinase kinase

J. A. Spicer, 2008, Expert opinion on drug discovery.

Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs.

J. A. Spicer, S. Gamage, W. Denny, 2000, Journal of medicinal chemistry.

Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

J. A. Spicer, S. Gamage, W. Denny, 1997, Journal of medicinal chemistry.

Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell–Mediated Neuroinflammation

J. A. Spicer, B. Engelhardt, J. Trapani, 2023, Neurology: Neuroimmunology & Neuroinflammation.

Benzenesulphonamide inhibitors of the cytolytic protein perforin

J. A. Spicer, W. Denny, J. Trapani, 2017, Bioorganic & medicinal chemistry letters.

Diarylthiophenes as inhibitors of the pore-forming protein perforin

J. A. Spicer, W. Denny, J. Trapani, 2016, Bioorganic & medicinal chemistry letters.

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

J. A. Spicer, W. Denny, J. Trapani, 2015, European journal of drug metabolism and pharmacokinetics.

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.

J. A. Spicer, W. Denny, J. Trapani, 2012, Bioorganic & medicinal chemistry.

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

J. A. Spicer, W. Denny, J. Trapani, 2008, Journal of medicinal chemistry.