Brian K. Kobilka

发表

Structure-based discovery of opioid analgesics with reduced side effects

Henry Lin, Grégory Scherrer, Aashish Manglik, 2016, Nature.

Quantifying and localizing interactions guiding the structural and functional properties of GPCRs

Brian K. Kobilka, P. S. Paul, Michael Zocher, 2013 .

Structural basis for nucleotide exchange in heterotrimeric G proteins

Ron O. Dror, Aashish Manglik, Brian K. Kobilka, 2015, Science.

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Brian K. Kobilka, Jeffrey L. Benovic, Henrik G. Dohlman, 1986, Nature.

Structure and Function of an Irreversible Agonist-β2 Adrenoceptor complex

Cheng Zhang, Ron O. Dror, Brian K. Kobilka, 2010, Nature.

Diverse GPCRs exhibit conserved water networks for stabilization and activation

A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, 2019, Proceedings of the National Academy of Sciences.

High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.

Brian K. Kobilka, Raymond C. Stevens, Vadim Cherezov, 2007 .

Isoflurane and Nociception: Spinal &agr;2A Adrenoceptors Mediate Antinociception while Supraspinal &agr;1 Adrenoceptors Mediate Pronociception

Brian K. Kobilka, Mervyn Maze, T. Guo, 2002, Anesthesiology.

Structural mechanisms of selectivity and gating in anion channelrhodopsins

Hideki Kandori, Ron O. Dror, Brian K. Kobilka, 2018, Nature.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

Ron O. Dror, Brian K. Kobilka, Naomi R. Latorraca, 2019, Cell.

Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

Brian K. Kobilka, A. Arnsten, B. Kobilka, 2002, The Journal of Neuroscience.

Shared decision-making drives collective movement in wild baboons

Aashish Manglik, Brian K. Kobilka, Ansgar Philippsen, .

Single-molecule analysis of ligand efficacy in β2AR-G protein activation

Jonathan A. Javitch, Brian K. Kobilka, Harel Weinstein, 2017, Nature.

Structure-based discovery of β2-adrenergic receptor ligands

Peter Kolb, Brian K. Kobilka, Brian K. Shoichet, 2009, Proceedings of the National Academy of Sciences.

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

Brian K. Kobilka, William I. Weis, Y. Zou, 2012, PloS one.

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

Ron O. Dror, Brian K. Kobilka, Naomi R. Latorraca, 2019, Cell.

Muscarinic acetylcholine receptors: novel opportunities for drug development

Arthur Christopoulos, Brian K. Kobilka, Patrick M. Sexton, 2014, Nature Reviews Drug Discovery.

Uncovering patterns of atomic interactions in static and dynamic structures of proteins

A. J. Venkatakrishnan, M. Madan Babu, Ron O. Dror, 2019, bioRxiv.

Propagation of conformational changes during μ-opioid receptor activation

Aashish Manglik, Brian K. Kobilka, Sébastien Granier, 2015, Nature.

High-resolution Crystal Structure of Human Protease-activated Receptor 1 Bound to the Antagonist Vorapaxar Hhs Public Access

Cheng Zhang, Ron O. Dror, Brian K. Kobilka, 2022 .

Irreversible Agonist-Beta2 Adrenoceptor Complex

Cheng Zhang, Ron O. Dror, Brian K. Kobilka, 2011 .

Structure of the δ-opioid receptor bound to naltrindole

Aashish Manglik, Brian K. Kobilka, Andrew C. Kruse, 2012, Nature.

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Arthur Christopoulos, Brian K. Kobilka, Mark G. Bures, 2016, Nature.

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

Brian K. Kobilka, Lutz Hein, Gregory S. Barsh, 1995, Nature.

High-resolution crystal structure of human Protease-Activated Receptor 1 bound to the antagonist vorapaxar

Ron O. Dror, Brian K. Kobilka, Cheng Zhang, 2012, Nature.

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1

Hideki Kandori, Ron O. Dror, Brian K. Kobilka, 2018, Nature.

Structural insights into μ-opioid receptor activation

Stephen M. Husbands, A. J. Venkatakrishnan, Ron O. Dror, 2015, Nature.

Structural Instability of a Constitutively Active G Protein-coupled Receptor

Brian K. Kobilka, Harel Weinstein, Roland Seifert, 1997, The Journal of Biological Chemistry.

Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes

Brian K. Kobilka, Yang Xiang, R. Tsien, 2007, The Journal of cell biology.