Bryan L. Roth

发表

Structure-based discovery of opioid analgesics with reduced side effects

Henry Lin, Grégory Scherrer, Aashish Manglik, 2016, Nature.

Application of Quantitative Structure–Activity Relationship Models of 5-HT1A Receptor Binding to Virtual Screening Identifies Novel and Potent 5-HT1A Ligands

Alexander Golbraikh, Bryan L. Roth, Alexander Tropsha, 2014, J. Chem. Inf. Model..

Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation

Hao Tang, Xi-Ping Huang, Bryan L. Roth, 2009, J. Chem. Inf. Model..

Faculty Opinions recommendation of Quantifying secondary transport at single-molecule resolution.

Bryan L. Roth, B. Roth, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data

Maria F. Sassano, Bryan L. Roth, Alexander Tropsha, 2014, Bioinform..

“TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”

John D. McCorvy, Bryan L. Roth, Tao Che, 2020, Nature Chemical Biology.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Xin Chen, Sheng Wang, Jian Jin, 2015, Nature.

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Xi-Ping Huang, Bryan L. Roth, Michael J. Krashes, 2015, Neuron.

Author response: Donated chemical probes for open science

Adriaan P. IJzerman, Bryan L. Roth, Anton Simeonov, 2018 .

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor

Maria F. Sassano, Bryan L. Roth, Brian K. Shoichet, 2013, ACS chemical biology.

A Pharmacological Organization of G Protein-coupled Receptors

Maria F. Sassano, Bryan L. Roth, Brian K. Shoichet, 2012, Nature Methods.

Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein‐coupled receptor activation in vivo

Bryan L. Roth, B. Roth, K. McCarthy, 2013, The Journal of physiology.

Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

Bryan L. Roth, B. Roth, K. A. O'Connor, 2005, Nature Reviews Drug Discovery.

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Jian Jin, Bryan L. Roth, Mark J. Zylka, 2011, Nature.

Silencing Synapses with DREADDs

Bryan L. Roth, B. Roth, Hu Zhu, 2014, Neuron.

A chemical-genetic approach to study G protein regulation of β cell function in vivo

Jian Hua Li, Bryan L. Roth, Frank J. Gonzalez, 2009, Proceedings of the National Academy of Sciences.

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

David E. Gloriam, John D. McCorvy, Bryan L. Roth, 2018, Cell.

Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.

Bryan L. Roth, Dale L. Boger, Peter K. Vogt, 2011, Journal of the American Chemical Society.

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding

Maria F. Sassano, Bryan L. Roth, Brian K. Shoichet, 2013, PLoS biology.

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

Hyunah Choo, Jian Jin, Bryan L. Roth, 2015, ACS chemical neuroscience.

WAY-100635 is a potent dopamine D4 receptor agonist

Bryan L. Roth, David E. Nichols, Val J. Watts, 2006, Psychopharmacology.

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen

Bryan L. Roth, Brian K. Shoichet, Michael J. Keiser, 2011, Nature chemical biology.

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

Bryan L. Roth, Nicola A. Colabufo, F. Ivy Carroll, 2013, PloS one.

Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors

Maria F. Sassano, Bryan L. Roth, Brian K. Shoichet, 2013, Journal of medicinal chemistry.

Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Bryan L. Roth, Richard A. Glennon, Philip D. Mosier, 2008, Journal of medicinal chemistry.

Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex

Paul B. Manis, Bryan L. Roth, B. Roth, 2008, Hearing Research.

Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders

Bryan L. Roth, B. Roth, A. Blum, 2004, Psychopharmacology.

Ligand Discovery from a Dopamine D3 Receptor Homology Model and Crystal Structure

Avner Schlessinger, Bryan L. Roth, Brian K. Shoichet, 2011, Nature chemical biology.

Polypharmacological Drugs: "Magic Shotguns" for Psychiatric Diseases

Bryan L. Roth, Wesley K. Kroeze, B. Roth, 2012 .

STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE

Anat Levit, Bryan L. Roth, Brian K. Shoichet, 2018, Nature.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.

Bryan L. Roth, B. Roth, Feng Yan, 2004, Life sciences.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Arthur Christopoulos, Jonathan A. Javitch, Bryan L. Roth, 2007, Journal of Pharmacology and Experimental Therapeutics.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

John D. McCorvy, Bryan L. Roth, Brian K. Shoichet, 2020, Nature.

Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment

Bryan L. Roth, V. Setola, Xi-Ping Huang, 2009, Molecular Pharmacology.

Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2012, Nature.

Unexplored therapeutic opportunities in the human genome

Anton Simeonov, Christian von Mering, Tudor I. Oprea, 2018, Nature Reviews Drug Discovery.

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

Bryan L. Roth, Xi-Ping Huang, B. Roth, 2009, Psychopharmacology.

Molecular control of δ-opioid receptor signalling

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2014, Nature.

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Jing Liu, Jian Jin, John D. McCorvy, 2016, Nature chemical biology.

Structure of the human kappa opioid receptor in complex with JDTic

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2012, Nature.

Structure of the human smoothened receptor bound to an antitumour agent

Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov, 2013, Nature.

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

Bryan L. Roth, Paul Ernsberger, Richard B. Rothman, 2002, Proceedings of the National Academy of Sciences of the United States of America.