Michel C. Nussenzweig

发表

Targeting HIV using Structure-Based Rational Design of Antibodies

Florian Klein, Pamela J. Bjorkman, Ron Diskin, 2014 .

Identification of chromosomal translocation hotspots via scan statistics

Rafael Rosales, Israel T. da Silva, Michel C. Nussenzweig, 2013, Bioinform..

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

Maxim N. Artyomov, Michael S. Seaman, Herman N. Eisen, 2010, Nature.

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Baoshan Zhang, Peter D. Kwong, Michael S. Seaman, 2015, Nature.

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

Michel C. Nussenzweig, Kayo Inaba, R. Steinman, 2001, The Journal of experimental medicine.

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

Michael Meyer-Hermann, Michael L. Dustin, Michel C. Nussenzweig, 2010, Cell.

Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies

Anthony P. West, Pamela J. Bjorkman, Michel C. Nussenzweig, 2020, bioRxiv.

Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

Michel C. Nussenzweig, M. Nussenzweig, Shiaoching Gong, 1996, Science.

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Ron Diskin, Beatrix Ueberheide, Michael S. Seaman, 2011, Science.

Clonal selection in the germinal centre by regulated proliferation and hypermutation

Michel C. Nussenzweig, M. Nussenzweig, Ziv Shulman, 2014, Nature.

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Michael S. Seaman, Florian Klein, Anthony P. West, 2015, Nature.

Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

Michel C. Nussenzweig, Scott W. Lowe, Mila Jankovic, 2006, Nature.

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Tongqing Zhou, Ron Diskin, Peter D. Kwong, 2013, Cell.

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

Michel C. Nussenzweig, Mila Jankovic, Wolfgang Resch, 2013, Science.

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

Michael S. Seaman, Yan Liu, Pamela J. Bjorkman, 2012, Proceedings of the National Academy of Sciences.

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Thomas Ried, Tasuku Honjo, Michel C. Nussenzweig, 2001, Nature.

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

Ron Diskin, Michael S. Seaman, Florian Klein, 2011, Science.

Antibodies in HIV-1 Vaccine Development and Therapy

Florian Klein, Johannes F. Scheid, Michel C. Nussenzweig, 2013, Science.

Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

Michel C. Nussenzweig, R. Steinman, M. Nussenzweig, 2002, Proceedings of the National Academy of Sciences of the United States of America.

B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity

Yijun Ruan, Zhonghui Tang, Ewy Mathé, 2014, Cell.

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

Michel C. Nussenzweig, R. Steinman, M. Nussenzweig, 2002, The Journal of experimental medicine.

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

Michael L. Dustin, Michel C. Nussenzweig, A. Rudensky, 2009, The Journal of experimental medicine.

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Steven M. Holland, Amelia Licari, Gian Luigi Marseglia, 2020, Science.

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

Michel C. Nussenzweig, Mila Jankovic, Wolfgang Resch, 2011, Cell.

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

Michel C. Nussenzweig, Frederick W. Alt, Robin M. Meyers, 2015, Nature.

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

Lynn Morris, Bette Korber, Tanmoy Bhattacharya, 2016, PLoS pathogens.

DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes

Ty C. Voss, Michel C. Nussenzweig, Mila Jankovic, 2012, Nature.

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2010, Science.

A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

Yoshiaki Nishimura, Michael S. Seaman, Dean A. Follmann, 2018, Nature Medicine.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Nico Pfeifer, Michael S. Seaman, Florian Klein, 2018, Nature.

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Young Do Kwon, Tongqing Zhou, Gwo-Yu Chuang, 2013, Journal of Virology.

Germinal center reutilization by newly activated B cells

Michel C. Nussenzweig, M. Nussenzweig, T. Manser, 2009, The Journal of experimental medicine.

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

Lynn Morris, Yan Liu, Michael S. Seaman, 2012, The Journal of experimental medicine.

Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

Florian Klein, Anthony P. West, Pamela J. Bjorkman, 2014, Cell.

HIV-1 Integration Landscape during Latent and Active Infection

Florian Klein, Gerald H. Learn, Clara Lehmann, 2015, Cell.

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Richard T. Wyatt, Michael S. Seaman, John R. Mascola, 2009, Nature.

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Ron Diskin, Michael S. Seaman, Florian Klein, 2012, Nature.

Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes

Bette Korber, Hongmei Gao, John R. Mascola, 2014, Journal of Virology.

Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability

James E. Bradner, Donna Neuberg, X. Shirley Liu, 2014, Cell.

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Thomas Ried, Michel C. Nussenzweig, M. Nussenzweig, 2000, Nature.

Dynamic imaging of the immune system: progress, pitfalls and promise

Michael L. Dustin, Ronald N. Germain, Michel C. Nussenzweig, 2006, Nature Reviews Immunology.

In vivo imaging of germinal centres reveals a dynamic open structure

Michael L. Dustin, Michel C. Nussenzweig, Randall L. Lindquist, 2007, Nature.

Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans

Michel C. Nussenzweig, A. Fischer, M. Nussenzweig, 2001, The Journal of experimental medicine.

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

Nico Pfeifer, Michael S. Seaman, Florian Klein, 2016, Science.

A robust pipeline for rapid production of versatile nanobody repertoires

David Fenyö, Johannes F. Scheid, Michel C. Nussenzweig, 2014, Nature Methods.

Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys

Michael S. Seaman, Florian Klein, Arup K. Chakraborty, 2013, Nature.

Genomic Instability in Mice Lacking Histone H2AX

Michel C. Nussenzweig, Lino Tessarollo, Bernardo Reina-San-Martin, 2002, Science.

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

Michel C. Nussenzweig, M. Nussenzweig, A. Nussenzweig, 2001, The Journal of experimental medicine.

Extrathymic T Cell Lymphopoiesis

Michel C. Nussenzweig, Philippe Kourilsky, M. Nussenzweig, 2003, The Journal of experimental medicine.

Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

Ron Diskin, Michael S. Seaman, Florian Klein, 2013, The Journal of experimental medicine.

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Nico Pfeifer, Michael S. Seaman, Florian Klein, 2016, Nature.