Isaac S. Kohane

发表

Clinical Concept Embeddings Learned from Massive Sources of Medical Data pdf

Tianxi Cai, Andrew L. Beam, Benjamin Kompa, 2018, ArXiv.

Towards generative adversarial networks as a new paradigm for radiology education pdf

Isaac S. Kohane, Samuel G. Finlayson, Hyunkwang Lee, 2018, ArXiv.

An Alert System for ED Laboratory Test Results

Isaac S. Kohane, Hongmei Dong, David S. Greenes, 1998, AMIA.

A Two-Tiered Database Cache Mechanism for a Clinician's Workstation.

Isaac S. Kohane, David P. McCallie, 1990 .

Adaptive Knowledge-Based Monitoring for Information Assurance

Jon Doyle, Peter Szolovits, William J. Long, 1998 .

Supporting Population Queries and Clinical Trials in i2b2 with SMART

Kenneth D. Mandl, Isaac S. Kohane, Nich Wattanasin, 2012, American Medical Informatics Association Annual Symposium.

Reverse Geocoding: Concerns about Patient Confidentiality in the Display of Geospatial Health Data

Kenneth D. Mandl, John S. Brownstein, Isaac S. Kohane, 2005, AMIA.

SecurityEmpire: Development and Evaluation of a Digital Game to Promote Cybersecurity Education

Marc Olano, Alan T. Sherman, John Seymour, 2014, 3GSE.

First Steps Towards Implementing an International Training Program in Medical Informatics: The Brazil/USA Project

Aziz A. Boxwala, Robert A. Greenes, Lucila Ohno-Machado, 2000, AMIA.

A Submission Model for Use in the Indexing, Searching, and Retrieval of Distributed Pathology Case and Tissue Specimens

Isaac S. Kohane, Henry C. Chueh, Ahmad H. Namini, 2004, MedInfo.

Healthconnect: clinical grade patient-physician communication

Kenneth D. Mandl, Isaac S. Kohane, I. Kohane, 1999, AMIA.

Adversarial attacks on medical machine learning

Andrew L. Beam, Isaac S. Kohane, Jonathan L. Zittrain, 2019, Science.

MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes

Alberto Riva, Voichita D. Marinescu, Isaac S. Kohane, 2005, BMC Bioinformatics.

PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies

Sheng Yu, Boris P. Hejblum, Isaac S. Kohane, 2018, J. Am. Medical Informatics Assoc..

Localization and Characterization of Mouse-Human Alignments Within the Human Genome. Does Evolutionary Conservation Suggest Functional Importance?

Isaac S. Kohane, Sunil Saluja, 2003, AMIA.

Collating of a Distributed XML-based Medical Records into a Relational Database

Alberto Riva, Kenneth D. Mandl, Isaac S. Kohane, 2000, AMIA.

Designing a Public Square for Research Computing

Paul A. Harris, Paul A. Fearn, Isaac S. Kohane, 2012, Science Translational Medicine.

Apps to display patient data, making SMART available in the i2b2 platform

Kenneth D. Mandl, Isaac S. Kohane, Nich Wattanasin, 2012, AMIA.

Technical desiderata for the integration of genomic data into Electronic Health Records

Isaac S. Kohane, Daniel R. Masys, Nicholas R. Anderson, 2012, J. Biomed. Informatics.

The Personal Internetworked Notary and Guardian

Peter Szolovits, Atul J. Butte, Alberto Riva, 2001, Int. J. Medical Informatics.

Human Genome Variation: Linking Genotypes to Clinical Phenotypes - Session Introduction

Francisco M. de la Vega, Isaac S. Kohane, Martin Kreitman, 2000, Pacific Symposium on Biocomputing.

An Epistemology for Clinically Significant Trends

Ira J. Haimowitz, Isaac S. Kohane, I. Kohane, 1993, AAAI.

LRTree: A Hybrid technique for Classifying Myocardial Infarction Data Containing Unknown Attribute Values

Isaac S. Kohane, Hamish S. F. Fraser, Christine L. Tsien, 1998, PAKDD.

Integration of the Personally Controlled Electronic Medical Record into a Regional and Data Exchange: A National Demonstration

Kenneth D. Mandl, Isaac S. Kohane, John D. Halamka, 2006, AMIA.

The MAPPER database: a multi-genome catalog of putative transcription factor binding sites

Alberto Riva, Voichita D. Marinescu, Isaac S. Kohane, 2004, Nucleic Acids Res..

Mutual information relevance networks

Atul J. Butte, Isaac S. Kohane, A. Butte, 2000 .

Bayesian Clustering of Gene Expression Dynamics

Paola Sebastiani, Marco F. Ramoni, Isaac S. Kohane, 2003 .

Health information identification and de-identification toolkit

Peter Szolovits, Isaac S. Kohane, Hongmei Dong, 1998, AMIA.

GrowthCalc: An Anthropometric Calculator Accessible Via the World Wide Web

Isaac S. Kohane, Daniel J. Nigrin, I. Kohane, 1998 .

Characterizing the Fever Effect in Autism Spectrum Disorder

Isaac S. Kohane, Eitan Bachmat, Denis Agniel, 2016, AMIA.

A Distributed, Secure File System For Personal Medical Records

Alberto Riva, Kenneth D. Mandl, Isaac S. Kohane, 2000, AMIA.

A SNP-centric database for the investigation of the human genome

Alberto Riva, Isaac S. Kohane, I. Kohane, 2004, BMC Bioinformatics.

Comparing expression profiles of genes with similar promoter regions

Peter J. Park, Atul J. Butte, Isaac S. Kohane, 2002, Bioinform..

Mapping Tool for Maintaining Vocabulary Relationships

Isaac S. Kohane, Henry C. Chueh, Shawn N. Murphy, 2006, AMIA.

Artifact detection in cardiovascular time series monitoring data from preterm infants

Cungen Cao, Neil McIntosh, Isaac S. Kohane, 1999, AMIA.

Learning Contextual Hierarchical Structure of Medical Concepts with Poincairé Embeddings to Clarify Phenotypes

Andrew L. Beam, Isaac S. Kohane, Brett K. Beaulieu-Jones, 2018, PSB.

Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records.

Scott T. Weiss, Isaac S. Kohane, Yi Dai, 2009, Journal of the American Medical Informatics Association : JAMIA.

Editorial: Methods in Functional Genomics

Paola Sebastiani, Isaac S. Kohane, Marco Ramoni, 2003, Machine Learning.

The new peer review

Russ B. Altman, Isaac S. Kohane, 2000, AMIA.

Information Technology research challenges for healthcare: from discovery to delivery

Deborah Estrin, Eric Horvitz, Elizabeth D. Mynatt, 2011, SIGH.

High-throughput Multimodal Automated Phenotyping (MAP) with Application to PheWAS

Peter Szolovits, Jiehuan Sun, Isaac S. Kohane, 2019, bioRxiv.

Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture

Xiaobo Zhou, Keith Marsolo, George Hripcsak, 2014, J. Am. Medical Informatics Assoc..

Statistical Challenges in Functional Genomics

Paola Sebastiani, Marco F. Ramoni, Isaac S. Kohane, 2003 .

The Children's Hospital Clinician's Workstation.

Isaac S. Kohane, David P. McCallie, David M. Margulies, 1990 .

PGAGENE: integrating quantitative gene-specific results from the NHLBI Programs for Genomic Applications

Atul J. Butte, Isaac S. Kohane, Kyungjoon Lee, 2003, Bioinform..

Creating a Patient Information Commons from Multiple Research Informatics Platforms

Griffin M. Weber, Isaac S. Kohane, Michael Mendis, 2017, CRI.

Integrating Substitutable Medical Apps, Reusable Technologies (SMART) in the i2b2 Platform

Kenneth D. Mandl, Isaac S. Kohane, Nich Wattanasin, 2012, AMIA.

Automated Trend Detection with Alternate Temporal Hypotheses

Ira J. Haimowitz, Isaac S. Kohane, 1993, IJCAI.

Integrating the CCDA for Real-Time Patient Data in the i2b2 Platform

Kenneth D. Mandl, Isaac S. Kohane, Nich Wattanasin, 2013, AMIA.

Toward More Transparent and Reproducible Omics Studies Through a Common Metadata Checklist and Data Publications

Lennart Martens, Stefano Toppo, Geoffrey C. Fox, 2013, Big Data.

Organization and Transformation of Next-Generation Sequencing Data for Use within i2b2

Isaac S. Kohane, Shawn N. Murphy, Lori C. Phillips, 2013, AMIA.

CHIP TUNER: a web tool for evidence-based noise reduction in gene discovery

Isaac S. Kohane, X. Gu, Christine L. Tsien, 2002, AMIA.

The Asthma Kiosk: A Patient-centered Technology for Collaborative Decision Support in the Emergency Department

Isaac S. Kohane, William Gribbons, Zhaohui Cai, 2004 .

SMART on FHIR: a standards-based, interoperable apps platform for electronic health records

Kenneth D. Mandl, Isaac S. Kohane, Rachel Badovinac Ramoni, 2016, J. Am. Medical Informatics Assoc..

Reproducibility of gene expression across generations of Affymetrix microarrays

Atul J. Butte, Isaac S. Kohane, Despina Sanoudou, 2003, BMC Bioinformatics.

Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative

Kenneth D. Mandl, Isaac S. Kohane, Rachel Badovinac Ramoni, 2014, J. Am. Medical Informatics Assoc..

Patient-controlled Pediatric Immunization Records

Kenneth D. Mandl, Isaac S. Kohane, Eric C. Pan, 2002, AMIA.

Development of a Parent-completed Electronic Interview to Assess Dehydration

Kenneth D. Mandl, Isaac S. Kohane, Gary R. Fleisher, 2000, AMIA.

An interactive online dashboard for tracking COVID-19 in U.S. counties, cities, and states in real time

Judith W. Dexheimer, Isaac S. Kohane, Michal Kouril, 2020, J. Am. Medical Informatics Assoc..

Confidentiality of Medical Records in the W3-EMRS Project

Peter Szolovits, Charles Safran, David M. Rind, 1997, AMIA.

Getting the data in

Isaac S. Kohane, I. Kohane, 1994 .

Quantifying the white blood cell transcriptome as an accessible window to the multiorgan transcriptome

Isaac S. Kohane, Vladimir I. Valtchinov, I. Kohane, 2012, Bioinform..

CrossChip: a system supporting comparative analysis of different generations of Affymetrix arrays

Byoung-Tak Zhang, Peter J. Park, Isaac S. Kohane, 2005, Bioinform..

White Paper: Training the Next Generation of Informaticians: The Impact of "BISTI" and Bioinformatics - A Report from the American College of Medical Informatics

David Tuck, Russ B. Altman, Perry L. Miller, 2004, J. Am. Medical Informatics Assoc..

VarSight: prioritizing clinically reported variants with binary classification algorithms

Yong Huang, Alexa T. McCray, Pengfei Liu, 2019, BMC Bioinformatics.

SNPper: retrieval and analysis of human SNPs

Alberto Riva, Isaac S. Kohane, I. Kohane, 2002, Bioinform..

Bioinformatics Applications Note Databases and Ontologies Automated Validation of Genetic Variants from Large Databases: Ensuring That Variant References Refer to the Same Genomic Locations

Isaac S. Kohane, Christopher A. Cassa, Mark Y. Tong, 2022 .

Quantifying the white blood cell transcriptome as an accessible window to the multiorgan transcriptome

Isaac S. Kohane, Vladimir I. Valtchinov, I. Kohane, 2012, Bioinform..

Reproducible and Shareable Quantifications of Pathogenicity

Isaac S. Kohane, Chirag J. Patel, Arjun K. Manrai, 2016, PSB.

Lower expression of genes near microRNA in C. elegans germline

Yutaka Fukuoka, Isaac S. Kohane, Hidenori Inaoka, 2006, BMC Bioinformatics.

Adversarial Attacks Against Medical Deep Learning Systems pdf

Andrew L. Beam, Isaac S. Kohane, Samuel G. Finlayson, 2018, ArXiv.

SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care

Gil Alterovitz, Shilin Zhu, Jeremy L. Warner, 2016, J. Am. Medical Informatics Assoc..

Monitor-driven data visualization

Isaac S. Kohane, James C. Fackler, I. Kohane, 1994 .

Increasing the efficiency of trial-patient matching: automated clinical trial eligibility Pre-screening for pediatric oncology patients

Louise Deléger, Isaac S. Kohane, Yizhao Ni, 2015, BMC Medical Informatics and Decision Making.

Dynamic Bayesian Networks in Modelling Cellular Systems: a Critical Appraisal on Simulated Data

Riccardo Bellazzi, Paola Sebastiani, Isaac S. Kohane, 2006, 19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06).

Scaling a data retrieval and mining application to the enterprise-wide level

Isaac S. Kohane, Daniel J. Nigrin, I. Kohane, 1999, AMIA.

Glucoweb: a case study of secure, remote biomonitoring and communication

Isaac S. Kohane, Daniel J. Nigrin, 2000, AMIA.

Surrogate-assisted feature extraction for high-throughput phenotyping

Peter Szolovits, Sheng Yu, Tianxi Cai, 2016, J. Am. Medical Informatics Assoc..

Atul J. Butte, Isaac S. Kohane, Ben Y. Reis, 2001, J. Biomed. Informatics.

Classifying Non-Small Cell Lung Cancer Histopathology Types and Transcriptomic Subtypes using Convolutional Neural Networks

Russ B. Altman, Isaac S. Kohane, Kun-Hsing Yu, 2019, bioRxiv.

Subtype Discovery for Autism Spectrum Disorder by Comorbidity Analysis

Nathan P. Palmer, Isaac S. Kohane, Kun-Hsing Yu, 2017, AMIA.

Parental Input into the Emergency Department Medical Record

Kenneth D. Mandl, Isaac S. Kohane, Gary R. Fleisher, 1998, American Medical Informatics Association Annual Symposium.

Approaching Causality: Discovering Time-Lag Correlations in Genetic Expression Data with Static and Dynamic Relevance Networks

Atul J. Butte, Isaac S. Kohane, Ben Y. Reis, 2000 .

Characterization of Patients who Suffer Asthma Exacerbations using Data Extracted from Electronic Medical Records

Scott T. Weiss, Isaac S. Kohane, Marco Ramoni, 2008, AMIA.

Unsupervised learning from complex data

Isaac S. Kohane, Lucila Ohno-Machado, J. H. Kim, 2001 .

Practical Health Information Exchange using a Personally Controlled Health Record

Kenneth D. Mandl, Isaac S. Kohane, Ben Adida, 2010, HealthSec.

Comparing the Similarity of Time-Series Gene Expression Using Signal Processing Metrics

Atul J. Butte, Isaac S. Kohane, Ling Bao, 2001, J. Biomed. Informatics.

Implementation of an electronic medical record system in a pediatric psychopharmacology program

Isaac S. Kohane, David Ray DeMaso, Joseph Gonzalez-Heydrich, 2000, Int. J. Medical Informatics.

DITTO - a Tool for Identification of Patient Cohorts from the Text of Physician Notes in the Electronic Medical Record

Isaac S. Kohane, Alexander Turchin, Merri L. Pendergrass, 2005, AMIA.

Bioinformatics in Functional Genomics

Atul J. Butte, Isaac S. Kohane, 2005 .

High-throughput Phenotyping via Denoised Normal Mixture Transformation

Peter Szolovits, Sheng Yu, Tianxi Cai, 2017, AMIA.

Strategies for maintaining patient privacy in i2b2

Isaac S. Kohane, Vivian S. Gainer, Michael Mendis, 2011, J. Am. Medical Informatics Assoc..

Letters to the Editor: No Structure Before Its Time

Özlem Uzuner, Isaac S. Kohane, 2008, J. Am. Medical Informatics Assoc..

Extracting Knowledge from Dynamics in Gene Expression

Atul J. Butte, Isaac S. Kohane, Ben Y. Reis, 2001, J. Biomed. Informatics.

High-Throughput Multimodal Automated Phenotyping (MAP) Incorporating Natural Language Processing with Application to PheWAS

Peter Szolovits, Jiehuan Sun, Isaac S. Kohane, 2018, AMIA.

TEMPORAL REASONING IN MEDICAL EXPERT SYSTEMS

Isaac S. Kohane, 1987 .

Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)

Griffin M. Weber, Isaac S. Kohane, Vivian S. Gainer, 2010, J. Am. Medical Informatics Assoc..

Unsupervised Learning from Complex Data: The Matrix Incision Tree Algorithm

Lucila Ohno-Machado, Isaac S. Kohane, Ju-Han Kim, 2001, Pacific Symposium on Biocomputing.

A bayesian framework for statistical signal processing and knowledge discovery in proteomic engineering

Gil Alterovitz, Marco F. Ramoni, Isaac S. Kohane, 2005 .

Social equity and access to the World Wide Web and E-mail: implications for design and implementation of medical applications

Kenneth D. Mandl, Isaac S. Kohane, S. B. Katz, 1998, AMIA.

TOWARD MORE TRANSPARENT AND REPRODUCIBLE

Robert L. Grossman, Lennart Martens, Doron Lancet, 2013 .

The Architecture of MAITA A Tool For Monitoring, Analysis, and Interpretation

Jon Doyle, Peter Szolovits, Isaac S. Kohane, 2004 .

Informatics for Integrating Biology and the Bedside (I2b2) Clinical Trials (CT) Patient Ascertainment Suite

Isaac S. Kohane, Nich Wattanasin, Vivian S. Gainer, 2014, AMIA.

Application of Information Technology: Temporal Expressiveness in Querying a Time-stamp - based Clinical Database

Isaac S. Kohane, Daniel J. Nigrin, 2000, J. Am. Medical Informatics Assoc..

Application of Technology: Building National Electronic Medical Record Systems via the World Wide Web

Philip Greenspun, Peter Szolovits, Isaac S. Kohane, 1996, J. Am. Medical Informatics Assoc..

Computerized reminders to physicians in the emergency department: a web-based system to report late-arriving abnormal laboratory results

Isaac S. Kohane, David S. Greenes, Gary R. Fleisher, 2002, AMIA.

Improved de-identification of physician notes through integrative modeling of both public and private medical text

Guergana K. Savova, Isaac S. Kohane, Ben Y. Reis, 2013, BMC Medical Informatics and Decision Making.

Multiple signal integration by decision tree induction to detect artifacts in the neonatal intensive care unit

Neil McIntosh, Isaac S. Kohane, Christine L. Tsien, 2000, Artif. Intell. Medicine.

Model Formulation: The PING Personally Controlled Electronic Medical Record System: Technical Architecture

Kenneth D. Mandl, Isaac S. Kohane, William W. Simons, 2004, J. Am. Medical Informatics Assoc..

Toward high-throughput phenotyping: unbiased automated feature extraction and selection from knowledge sources

Peter Szolovits, Sheng Yu, Tianxi Cai, 2015, J. Am. Medical Informatics Assoc..

Learning to Estimate Nutrition Facts from Food Descriptions

Andrew L. Beam, Isaac S. Kohane, Hadi Amiri, 2019, AMIA.

Human Genome Variation: Haplotypes, Linkage Disequilibrium, and Populations - Session Introduction

Francisco M. de la Vega, Isaac S. Kohane, Kenneth K. Kidd, 2003, Pacific Symposium on Biocomputing.

Identifying patient smoking status from medical discharge records.

Yuan Luo, Özlem Uzuner, Isaac S. Kohane, 2008, Journal of the American Medical Informatics Association : JAMIA.

Methodology for Computer-Assisted Prediction of Growth Hormone Deficiency in Children

Isaac S. Kohane, Christine L. Tsien, Daniel J. Nigrin, 1998, AMIA.

The Spectrum of Insomnia-Associated Comorbidities in an Electronic Medical Records Cohort

Isaac S. Kohane, Andrew Beam, Uri Kartoun, 2016, AMIA.

Maximizing Data Portability in Patient-controlled Longitudinal Medical Records

Isaac S. Kohane, Matvey B. Palchuk, Eric C. Pan, 2002, AMIA.

Demonstrating the Advantages of Applying Data Mining Techniques on Time-Dependent Electronic Medical Records

Peter Szolovits, Sheng Yu, Tianxi Cai, 2015, AMIA.

Visualization and evaluation of clusters for exploratory analysis of gene expression data

Lucila Ohno-Machado, Isaac S. Kohane, Ju-Han Kim, 2002, J. Biomed. Informatics.

Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

Isaac S. Kohane, Judith Somekh, Shai S. Shen-Orr, 2019, BMC Bioinformatics.

Linking multiple heterogeneous data sources to practice guidelines

Yao Sun, Kenneth D. Mandl, Isaac S. Kohane, 1998, AMIA.

Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data

Tianxi Cai, Griffin M. Weber, Andrew L. Beam, 2018, PSB.

Unsupervised knowledge discovery in medical databases using relevance networks

Atul J. Butte, Isaac S. Kohane, A. Butte, 1999, AMIA.

A Model for Distributed Vocabulary Translation

Peter Szolovits, Isaac S. Kohane, Jiri Schindler, 1996 .

A translational engine at the national scale: informatics for integrating biology and the bedside

Isaac S. Kohane, Shawn N. Murphy, Susanne E. Churchill, 2012, J. Am. Medical Informatics Assoc..

An unsupervised self-optimizing gene clustering algorithm

Isaac S. Kohane, Asher D. Schachter, 2002, AMIA.

Managing temporal worlds for medical trend diagnosis

Ira J. Haimowitz, Isaac S. Kohane, I. Kohane, 1996, Artif. Intell. Medicine.

SHRINE: Enabling Nationally Scalable Multi-Site Disease Studies

Douglas MacFadden, Philip Trevvett, Isaac S. Kohane, 2013, PloS one.

Data mining by clinicians

Isaac S. Kohane, Daniel J. Nigrin, I. Kohane, 1998, AMIA.

Determining Significant Fold Differences in Gene Expression Analysis

Atul J. Butte, Isaac S. Kohane, J. Ye, 2000, Pacific Symposium on Biocomputing.

Bioinformatics and Clinical Informatics: The Imperative to Collaborate

Isaac S. Kohane, I. Kohane, 2000, J. Am. Medical Informatics Assoc..

A Java-based multi-institutional medical information retrieval system

Karen Bradshaw, Peter Szolovits, Kang Wang, 1997, AMIA.

Research Paper: Parents as Partners in Obtaining the Medication History

Isaac S. Kohane, Stephen C. Porter, Donald A. Goldmann, 2005, J. Am. Medical Informatics Assoc..

Policy Forum: Against Simple Universal Health-Care Identifiers

Peter Szolovits, Isaac S. Kohane, 1994, J. Am. Medical Informatics Assoc..

Brief Review: The Contributions of Biomedical Informatics to the Fight Against Bioterrorism

Isaac S. Kohane, I. Kohane, 2002, J. Am. Medical Informatics Assoc..

Approaching Small Molecule Prioritization as a Cross-Modal Information Retrieval Task through Coordinated Representation Learning pdf

Isaac S. Kohane, Samuel G. Finlayson, Matthew B. A. McDermott, 2019, ArXiv.

HealthConnect: A Structured Communication System for Health Management

Karen Bradshaw, Kenneth D. Mandl, Isaac S. Kohane, 1998, AMIA.

High-throughput Multimodal Automated Phenotyping (MAP) with Application to PheWAS

Peter Szolovits, Jie Huang, Jiehuan Sun, 2019 .

SMART on FHIR Genomics: facilitating standardized clinico-genomic apps

Gil Alterovitz, Jeremy L. Warner, Isaac S. Kohane, 2015, J. Am. Medical Informatics Assoc..

Accessing genomic data through XML-based remote procedure calls

Alberto Riva, Isaac S. Kohane, I. Kohane, 2002, AMIA.

Knowledge-based Data Display Using TrenDx

Ira J. Haimowitz, Isaac S. Kohane, James C. Fackler, 1994 .

Feature extraction for phenotyping from semantic and knowledge resources

Sheng Yu, Tianxi Cai, Kenneth D. Mandl, 2019, J. Biomed. Informatics.

Building ICU artifact detection models with more data in less time

Neil McIntosh, Isaac S. Kohane, Christine L. Tsien, 2001, AMIA.

Clinical monitoring using regression-based trend templates

Ira J. Haimowitz, Isaac S. Kohane, P. P. Le, 1995, Artif. Intell. Medicine.

Bioinformatics in Functional Genomics

Atul J. Butte, Isaac S. Kohane, 2014 .

On Reporting Fold Differences

Isaac S. Kohane, X. Gu, Christine L. Tsien, 2000, Pacific Symposium on Biocomputing.

Artifact Detection in the PO2 and PCO2 Time Series Monitoring Data from Preterm Infants

Cungen Cao, Neil McIntosh, Kang Wang, 2004, Journal of Clinical Monitoring and Computing.

Improving the Review of Individual Patients in a Clinical Data Repository

Kenneth D. Mandl, Isaac S. Kohane, Nich Wattanasin, 2014, AMIA.

Agile monitoring for cyber defense

Jon Doyle, Peter Szolovits, William J. Long, 2001, Proceedings DARPA Information Survivability Conference and Exposition II. DISCEX'01.

Application of Information Technology The Shared Health Research Information Network ( SHRINE ) : A Prototype Federated Query Tool for Clinical Data Repositories

Douglas MacFadden, Griffin M. Weber, Isaac S. Kohane, 2014 .

ParentLink: A Web-Based Communications Tool for Parents and Pediatricians

Kenneth D. Mandl, Isaac S. Kohane, Charles J. Homer, 1998, AMIA.

Integration of Clinical and Genetic Data in the i2b2 Architecture

Isaac S. Kohane, Henry C. Chueh, Michael Mendis, 2006, AMIA.

A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease

Monika Heiner, Mor Peleg, Isaac S. Kohane, 2016, J. Biomed. Informatics.

The Future of Informatics in Biomedicine

Kenneth D. Mandl, Isaac S. Kohane, Mark E. Frisse, 2021, Biomedical Informatics.

Optimal Data Entry by Patients: Effects of Interface Structure and Design

Isaac S. Kohane, Stephen C. Porter, I. Kohane, 2001, MedInfo.

Architecture of the Open-source Clinical Research Chart from Informatics for Integrating Biology and the Bedside

Isaac S. Kohane, Vivian S. Gainer, Henry C. Chueh, 2007, AMIA.

Quantifying the relationship between co-expression, co-regulation and gene function

Atul J. Butte, Isaac S. Kohane, Dominic J. Allocco, 2004, BMC Bioinformatics.

Enrolling patients into clinical trials faster using RealTime Recuiting

Atul J. Butte, Isaac S. Kohane, David A. Weinstein, 2000, AMIA.

Scalability and cost-effectiveness analysis of whole genome-wide association studies on Google Cloud Platform and Amazon Web Services

Isaac S. Kohane, Paul Avillach, Chirag J. Patel, 2020, J. Am. Medical Informatics Assoc..

BioN∅T: A searchable database of biomedical negated sentences

Hong Yu, Shashank Agarwal, Isaac S. Kohane, 2011, BMC Bioinformatics.

Human Genome Variation: Disease, Drug Response, and Clinical Phenotypes - Session Introduction

Francisco M. de la Vega, Isaac S. Kohane, Julie A. Schneider, 2002, Pacific Symposium on Biocomputing.

Editorial

Isaac S. Kohane, I. Kohane, 1995, Artif. Intell. Medicine.

Interacting with eHealth: towards grand challenges for HCI

Ben Shneiderman, Desney S. Tan, Ryen W. White, 2009, CHI Extended Abstracts.

ksRepo: a generalized platform for computational drug repositioning

Isaac S. Kohane, Sek Won Kong, Chirag J. Patel, 2016, BMC Bioinformatics.

Scaling aDataRetrieval andMining Application TotheEnterprise-Wide Level

Isaac S. Kohane, Daniel J. Nigrin, 1999 .

Additional data file 10

Simon Kasif, Carol J. Bult, Isaac S. Kohane, 2008 .

Human Protein Meta-Interaction Database (HPMD) Potentiates Integration for Meta-Analysis

Gil Alterovitz, Marco F. Ramoni, Isaac S. Kohane, 2005 .

Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks

Atul J. Butte, Isaac S. Kohane, Cecily J. Wolfe, 2005, BMC Bioinformatics.

Marco Ramoni: an appreciation of academic achievement

Peter Szolovits, Isaac S. Kohane, I. Kohane, 2011, J. Am. Medical Informatics Assoc..

A web-based tool to retrieve human genome polymorphisms from public databases

Alberto Riva, Isaac S. Kohane, I. Kohane, 2001, AMIA.

ARTIFACTDETECTIONINTHEPO2 ANDPCO2 TIMESERIESMONITORINGDATAFROMPRETERM INFANTS

Cungen Cao, Isaac S. Kohane, 1999 .

A novel approach to investigate tissue-specific trinucleotide repeat instability

Jie Zhang, John R. Walker, Andrew I. Su, 2010, BMC Systems Biology.

Inferring cell cycle feedback regulation from gene expression data

Riccardo Bellazzi, Isaac S. Kohane, Marco Ramoni, 2011, J. Biomed. Informatics.

Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance

Peter J. Park, Simon Kasif, Isaac S. Kohane, 2009, Bioinform..

Analysis of matched mRNA measurements from two different microarray technologies

Lucila Ohno-Machado, Atul J. Butte, Tor-Kristian Jenssen, 2002, Bioinform..

Position Paper: Wireless Technology Infrastructures for Authentication of Patients: PKI that Rings

Ulrich Sax, Kenneth D. Mandl, Isaac S. Kohane, 2005, J. Am. Medical Informatics Assoc..

Building ICUArtifact Detection ModelsWithMoreDatainLessTime

Isaac S. Kohane, Christine L. Tsien, I. Kohane, 2001 .

Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements

Isaac S. Kohane, Zoltan Szallasi, Aron C. Eklund, 2005, BMC Bioinformatics.

Relevance Networks: A First Step Toward Finding Genetic Regulatory Networks Within Microarray Data

Isaac S. Kohane, Atul Janardhan Butte, A. Butte, 2003 .

START: an automated tool for serial analysis of chromatin occupancy data

Alberto Riva, Voichita D. Marinescu, Tae-Kyung Kim, 2006, Bioinform..

Guardian Angel: Patient-Centered Health Information Systems

Jon Doyle, Peter Szolovits, William J. Long, 1994 .

Smart on FHIR

Stanley M. Huff, Kenneth D. Mandl, Isaac S. Kohane, 2014, AMIA.

Linking gene expression data with patient survival times using partial least squares

Lu Tian, Peter J. Park, Isaac S. Kohane, 2002, ISMB.

Enabling phenotypic big data with PheNorm

Peter Szolovits, Sheng Yu, Tianxi Cai, 2018, J. Am. Medical Informatics Assoc..

ATLAS: An automated association test using probabilistically linked health records with application to genetic studies

Tianxi Cai, Boris P. Hejblum, Griffin M. Weber, 2021, medRxiv.

Finding commonalities in rare diseases through the undiagnosed diseases network

Nathan P. Palmer, Isaac S. Kohane, Vianney Jouhet, 2021, J. Am. Medical Informatics Assoc..

Attentive Multiview Text Representation for Differential Diagnosis

Isaac S. Kohane, Mitra Mohtarami, Hadi Amiri, 2021, ACL.

Patient-led data sharing for clinical bioinformatics research: USCDI and beyond

Kenneth D. Mandl, Isaac S. Kohane, Joshua C. Mandel, 2021, J. Am. Medical Informatics Assoc..

Cross-modal representation alignment of molecular structure and perturbation-induced transcriptional profiles

Isaac S. Kohane, Samuel G. Finlayson, Matthew B.A. McDermott, 2021, PSB.

Clinical Genome Sequencing

Robert C. Green, Isaac S. Kohane, Heidi L. Rehm, 2013 .

Characteristics and Predictive Value of Blood Transcriptome Signature in Males with Autism Spectrum Disorders

In-Hee Lee, Isaac S. Kohane, Sek Won Kong, 2012, PloS one.

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells

Isaac S. Kohane, Michal Galdzicki, Ze Tian, 2008, PloS one.

The Tell-Tale Heart: Population-Based Surveillance Reveals an Association of Rofecoxib and Celecoxib with Myocardial Infarction

Kenneth D. Mandl, John S. Brownstein, Isaac S. Kohane, 2007, PloS one.

Assessing the reproducibility of asthma genome-wide association studies in a general clinical population.

Scott T. Weiss, Isaac S. Kohane, Blanca E. Himes, 2011, The Journal of allergy and clinical immunology.

Examining the Use of Real‐World Evidence in the Regulatory Process

Russ B. Altman, Isaac S. Kohane, Brett K. Beaulieu-Jones, 2019, Clinical pharmacology and therapeutics.

Combining clinical and genomics queries using i2b2 – Three methods

Riccardo Bellazzi, Isaac S. Kohane, Matteo Gabetta, 2017, PloS one.

Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: A pilot study

Qing Zeng-Treitler, Isaac S. Kohane, Vivian S. Gainer, 2013, Psychiatry Research: Neuroimaging.

A One-Page Summary Report of Genome Sequencing for the Healthy Adult

Robert C. Green, Isaac S. Kohane, Heidi L. Rehm, 2015, Public Health Genomics.

Computational analysis of non-adherence and non-attendance using the text of narrative physician notes in the electronic medical record

Isaac S. Kohane, Alexander Turchin, Nikheel S. Kolatkar, 2007, Medical informatics and the Internet in medicine.

Development of an Algorithm to Identify Patients with Physician-Documented Insomnia

Andrew L. Beam, Isaac S. Kohane, Uri Kartoun, 2018, Scientific Reports.

Gene expression profiling of Duchenne muscular dystrophy skeletal muscle

Mei Han, Isaac S. Kohane, Despina Sanoudou, 2003, Neurogenetics.

A Practical Platform for Blood Biomarker Study by Using Global Gene Expression Profiling of Peripheral Whole Blood

Isaac S. Kohane, Patrick R. Schmid, Michal Galdzicki, 2009, PloS one.

Comparing Risk Scoring Systems Beyond the ROC Paradigm in Survival Analysis

Tianxi Cai, Isaac S. Kohane, Hajime Uno, 2009 .

Distinctive patterns of microRNA expression in primary muscular disorders

Isaac S. Kohane, Alan H. Beggs, Alal Eran, 2007, Proceedings of the National Academy of Sciences.

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis

Keith Marsolo, Marylyn D. Ritchie, Aleksey A. Porollo, 2014, Front. Genet..

Protein network topology metric conservation: from yeast to human

Gil Alterovitz, Isaac S. Kohane, Marco F. Ramoni, 2005 .

A 21st-Century Health IT System - Creating a Real-World Information Economy.

Kenneth D. Mandl, Isaac S. Kohane, I. Kohane, 2017, The New England journal of medicine.

Practical considerations in genomic decision support: The eMERGE experience

Keith Marsolo, Suzette J. Bielinski, Gerard Tromp, 2015, Journal of pathology informatics.

EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children

Keith Marsolo, Isaac S. Kohane, Todd Lingren, 2013, Front. Genet..

The CoMorbidity Burden of Children and Young Adults with Autism Spectrum Disorders

Douglas MacFadden, Isaac S. Kohane, Nich Wattanasin, 2012 .

Creating a data resource: what will it take to build a medical information commons?

John Wilbanks, Robert Gentleman, Isaac S. Kohane, 2017, Genome Medicine.

Autoantibodies, autoimmune risk alleles and clinical associations in rheumatoid arthritis cases and non-RA controls in the electronic medical records

Peter Szolovits, Joshua C. Denny, Tianxi Cai, 2013 .

Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study

Isaac S. Kohane, Andrew Cagan, Thomas H. McCoy, 2015, PloS one.

Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records

Peter Szolovits, Tianxi Cai, Guergana K. Savova, 2013, PloS one.

Prenatal antidepressant exposure is associated with risk for attention deficit-hyperactivity disorder but not autism spectrum disorder in a large health system

Isaac S. Kohane, Shawn N. Murphy, Jordan W. Smoller, 2014, Molecular Psychiatry.

A conceptual model for translating omic data into clinical action

Suzette J. Bielinski, Gerard Tromp, Christopher G. Chute, 2015, Journal of pathology informatics.

Reestablishing the Researcher-Patient Compact

Kenneth D. Mandl, Isaac S. Kohane, Daniel J. Nigrin, 2007, Science.

Expression profiles of the mouse lung identify a molecular signature of time-to-birth.

Isaac S. Kohane, Alvin T. Kho, Soumyaroop Bhattacharya, 2009, American journal of respiratory cell and molecular biology.

C. elegans exhibits coordinated oscillation in gene activation in single-cell developmental data

Bonnie Berger, Isaac S. Kohane, Luke A. D. Hutchison, 2018, bioRxiv.

Comparative RNA Editing in Autistic and Neurotypical Cerebella

Emery N. Brown, Isaac S. Kohane, Alal Eran, 2012, Molecular Psychiatry.

Managing incidental findings and research results in genomic research involving biobanks and archived data sets

Robert C. Green, Judy Illes, Isaac S. Kohane, 2012, Genetics in Medicine.

A Threat to Genomic Medicine

Russ B. Altman, Isaac S. Kohane, Daniel R. Masys, 2006 .

DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases

Isaac S. Kohane, Alan R. Bishop, Ludmil B. Alexandrov, 2011, PloS one.

C. Elegans Exhibits Coordinated Oscillation in Gene Expression During Development

Bonnie Berger, Isaac S. Kohane, Luke A. D. Hutchison, 2018 .

NATURAL LANGUAGE PROCESSING IMPROVES PHENOTYPIC ACCURACY IN AN ELECTRONIC MEDICAL RECORD COHORT OF TYPE 2 DIABETES AND CARDIOVASCULAR DISEASE

Peter Szolovits, Tianxi Cai, Isaac S. Kohane, 2014 .

A Web-Based Interface to Childhood Immunization Registries

Isaac S. Kohane, Eric M. Jordan, I. Kohane, 1996 .