Nigel Stallard

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Creating the repository database and data control

Sally Brown, Shilpa Patel, Siew Wan Hee, 2016 .

Methods used for multiparameter assay cost-effectiveness literature review

Peter Hall, Andrea Marshall, Nigel Stallard, 2016 .

Developing Simulation Tools in R for Planning Adaptive Seamless Designs: An Application in Multiple Sclerosis

Tim Friede, Nigel Stallard, Nicholas R. Parsons, 2009 .

Directions for new developments on statistical design and analysis of small population group trials

Ralf-Dieter Hilgers, Nigel Stallard, Kit Roes, 2016, Orphanet Journal of Rare Diseases.

dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials

Moreno Ursino, Tim Friede, Nigel Stallard, 2018, Comput. Methods Programs Biomed..

Clinical Trials Impacted by the COVID-19 Pandemic: Adaptive Designs to the Rescue?

Frank Bretz, Christoph Gerlinger, Tim Friede, 2020, Statistics in biopharmaceutical research.

Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19

Martin Posch, Werner Brannath, Thomas Jaki, 2020, Statistics in biopharmaceutical research.

Point estimation following two‐stage adaptive threshold enrichment clinical trials

Nigel Stallard, Susan Todd, Peter K Kimani, 2018, Statistics in medicine.

Recent advances in methodology for clinical trials in small populations: the InSPiRe project

Michael Pearce, Martin Posch, Gernot Wassmer, 2018, Orphanet Journal of Rare Diseases.

Efficiency of adaptive designs

Tim Friede, Nigel Stallard, T. Friede, 2010 .

Reply to the letter of Diener and Schlede

Nigel Stallard, Anne Whitehead, 1996 .

A New Clinical Trial Design Combining Phases 2 and 3: Sequential Designs with Treatment Selection and a Change of Endpoint

Nigel Stallard, Susan Todd, S. Todd, 2005 .

Repeated measures proportional odds logistic regression analysis of ordinal score data in the statistical software package R

Nick R. Parsons, Nigel Stallard, Juul Achten, 2009, Comput. Stat. Data Anal..

Decision‐making in a phase II clinical trial: a new approach combining Bayesian and frequentist concepts

Nigel Stallard, John Whitehead, Simon Cleall, 2005 .

Optical coherence tomography in secondary progressive multiple sclerosis: a baseline data report from the MS-SMART trial

Gavin Giovannoni, Dh Miller, Nigel Stallard, 2016 .

An alternative method to analyse the biomarker‐strategy design

Nigel Stallard, Thomas Jaki, Cornelia Ursula Kunz, 2018, Statistics in medicine.

A multi-stage drop-the-losers design for multi-arm clinical trials

Jack Bowden, Christopher Jennison, Nigel Stallard, 2016, Statistical methods in medical research.

Seamless phase II/III designs

Nigel Stallard, Susan Todd, S. Todd, 2011, Statistical methods in medical research.

ROI analysis of pharmafMRI data: an adaptive approach for global testing

Thomas E. Nichols, Nigel Stallard, Giorgos Minas, 2012 .

Extrapolating Parametric Survival Models in Health Technology Assessment: A Simulation Study

Nigel Stallard, Daniel Gallacher, Peter Kimani, 2020, Medical decision making : an international journal of the Society for Medical Decision Making.

An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection

Richard Nicholas, Nick R. Parsons, Tim Friede, 2012, Comput. Stat. Data Anal..

A group‐sequential design for clinical trials with treatment selection

Tim Friede, Nigel Stallard, T. Friede, 2008, Statistics in medicine.

A comparison of methods for constructing confidence intervals after phase II/III clinical trials

Nigel Stallard, Susan Todd, Peter K Kimani, 2014, Biometrical journal. Biometrische Zeitschrift.

Methodology and statistical developments 1: subgroup identification with recursive partitioning

Siew Wan Hee, Dipesh Mistry, Jake Jordan, 2016 .

Using Bayesian adaptive designs to improve phase III trials: a respiratory care example

Duncan Young, Sarah E Lamb, Nigel Stallard, 2019, BMC Medical Research Methodology.

Point and interval estimation in two-stage adaptive designs with time to event data and biomarker-driven subpopulation selection

Nigel Stallard, Susan Todd, Ekkehard Glimm, 2020, Statistics in medicine.

Sample data sharing agreement

Sarah E Lamb, Jason Madan, Siew Wan Hee, 2016 .

Sequential designs for phase III clinical trials incorporating treatment selection

Nigel Stallard, Susan Todd, S. Todd, 2003, Statistics in medicine.

Exact group‐sequential designs for clinical trials with randomized play‐the‐winner allocation

Nigel Stallard, William F Rosenberger, W. Rosenberger, 2002, Statistics in medicine.

Flexible selection of a single treatment incorporating short‐term endpoint information in a phase II/III clinical trial

Tim Friede, Nigel Stallard, Susan Todd, 2015, Statistics in medicine.

Additional details of the multiparameter tests

Peter Hall, Andrea Marshall, Nigel Stallard, 2016 .

Decision Analysis from the Perspectives of Single and Multiple Stakeholders

Martin Posch, Nigel Stallard, Robert A. Beckman, 2018 .

Instruction on secure data transfer

Sally Brown, Shilpa Patel, Siew Wan Hee, 2016 .

Comparison of Bayesian and frequentist group-sequential clinical trial designs

Nigel Stallard, Susan Todd, Elizabeth G. Ryan, 2020, BMC medical research methodology.

Designing a series of decision‐theoretic phase II trials in a small population

Siew Wan Hee, Nigel Stallard, S. Hee, 2012, Statistics in medicine.

Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R

Tim Friede, Nigel Stallard, Nicholas Parsons, 2020, Biometrical journal. Biometrische Zeitschrift.

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

David Armstrong, Lisa V Hampson, Nigel Stallard, 2018, British Medical Journal.

To add or not to add a new treatment arm to a multiarm study: A decision‐theoretic framework

Nigel Stallard, James Wason, Kim May Lee, 2019, Statistics in medicine.

Sequentially testing for a gene–drug interaction in a genomewide analysis

John Whitehead, Nigel Stallard, Yinghui Zhou, 2008, Statistics in medicine.

Optimized adaptive enrichment designs

Martin Posch, Nigel Stallard, Thomas Ondra, 2017, Statistical methods in medical research.

Statistical Methods for Combining Clinical Trial Phases II And III

Nigel Stallard, Susan Todd, S. Todd, 2007 .

A hybrid procedure for detecting global treatment effects in multivariate clinical trials: theory and applications to fMRI studies

Thomas E. Nichols, Nigel Stallard, Fabio Rigat, 2012, Statistics in medicine.

Sequential genome‐wide association studies for monitoring adverse events in the clinical evaluation of new drugs

John Whitehead, Nigel Stallard, J. Whitehead, 2006, Statistics in medicine.

Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD

Tim Friede, Nigel Stallard, Susan Todd, 2011, Trials.

Biostatistical Methodology in Carcinogenicity Studies

Nigel Stallard, Wout Slob, Ludwig A. Hothorn, 1998 .

Decision-theoretic designs for small trials and pilot studies: A review

Martin Posch, Sarah Zohar, Siew Wan Hee, 2015, Statistical methods in medical research.

An Adaptive Group Sequential Design for Phase II/III Clinical Trials that Select a Single Treatment From Several

Nigel Stallard, Susan Todd, Patrick J. Kelly, 2005, Journal of biopharmaceutical statistics.

Practical guidelines for adaptive seamless phase II/III clinical trials that use Bayesian methods

Nigel Stallard, Willi Maurer, Ekkehard Glimm, 2012, Statistics in medicine.

Identifying back pain subgroups: developing and applying approachesusing individual patient data collected within clinical trials

Sally Brown, Siew Wan Hee, Dipesh Mistry, 2016 .

Determination of the optimal sample size for a clinical trial accounting for the population size

Martin Posch, Sarah Zohar, Siew Wan Hee, 2016, Biometrical journal. Biometrische Zeitschrift.

A Comparison of Methods for Adaptive Treatment Selection

Tim Friede, Nigel Stallard, T. Friede, 2008, Biometrical journal. Biometrische Zeitschrift.

Correction: ‘A conditional error function approach for subgroup selection in adaptive clinical trials’

Tim Friede, Nigel Stallard, Nicholas R. Parsons, 2013 .

Decision‐Theoretic Designs for Phase II Clinical Trials Allowing for Competing Studies

Nigel Stallard, N. Stallard, 2003, Biometrics.

Decision‐theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta‐binomial distribution

Siew Wan Hee, Nigel Stallard, Nicholas Parsons, 2018, Biometrical journal. Biometrische Zeitschrift.

Protocol for a randomised controlled trial of Subacromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS)

Nigel Stallard, Martin Underwood, Iftekhar Khan, 2020, BMJ Open.

Effectiveness of a Web-Based Cognitive-Behavioral Tool to Improve Mental Well-Being in the General Population: Randomized Controlled Trial

Kathleen M Griffiths, Nigel Stallard, Amanda Burls, 2012, Journal of medical Internet research.

Group-Sequential Methods for Adaptive Seamless Phase II/III Clinical Trials

Nigel Stallard, N. Stallard, 2011, Journal of biopharmaceutical statistics.

Improving the Efficiency of Advanced Life Support Training

Nigel Stallard, Gavin D. Perkins, Ian Bullock, 2012, Annals of Internal Medicine.

OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer.

John M S Bartlett, Christopher McCabe, Nigel Stallard, 2016, Health technology assessment.

Statistical design and analysis of pharmacogenetic trials

Nigel Stallard, John C Whittaker, Patrick J. Kelly, 2005, Statistics in medicine.

Modified Weibull multi-state models for the analysis of animal carcinogenicity data

Nigel Stallard, Anne Whitehead, 2004, Environmental and Ecological Statistics.

Optimal sample sizes for phase II clinical trials and pilot studies

Nigel Stallard, N. Stallard, 2012, Statistics in medicine.

An adaptive group sequential design for clinical trials that involve treatment selection

Nigel Stallard, Susan Todd, Patrick J. Kelly, 2003 .

A hierarchical Bayesian model for predicting the functional consequences of amino‐acid polymorphisms

Claudio J. Verzilli, Nigel Stallard, Daniel I. Chasman, 2005 .

Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

Martin Posch, Sarah Zohar, Tim Friede, 2016, Orphanet Journal of Rare Diseases.

A confirmatory seamless phase II/III clinical trial design incorporating short‐term endpoint information

Nigel Stallard, N. Stallard, 2010, Statistics in medicine.

Adaptive Designs for Confirmatory Clinical Trials with Subgroup Selection

Tim Friede, Nigel Stallard, Thomas Hamborg, 2014, Journal of biopharmaceutical statistics.

Dose selection in seamless phase II/III clinical trials based on efficacy and safety

Nigel Stallard, Jane L Hutton, Peter K Kimani, 2009, Statistics in medicine.

A recursive partitioning approach for subgroup identification in individual patient data meta‐analysis

Dipesh Mistry, Nigel Stallard, Martin Underwood, 2018, Statistics in medicine.

Planning multi-arm screening studies within the context of a drug development program

Nigel Stallard, Thomas Jaki, James M S Wason, 2013, Statistics in medicine.

Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility

Nigel Stallard, Susan Todd, Peter K Kimani, 2013, Statistics in medicine.

Point estimates and confidence regions for sequential trials involving selection

Nigel Stallard, Susan Todd, S. Todd, 2005 .

Optimal choice of the number of treatments to be included in a clinical trial

Martin Posch, Tim Friede, Nigel Stallard, 2009, Statistics in medicine.

Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

John Whitehead, Nigel Stallard, Susan Todd, 2008 .

Seamless phase II/III clinical trials using early outcomes for treatment or subgroup selection: Methods and aspects of their implementation

Tim Friede, Nigel Stallard, T. Friede, 2019, 1901.08365.

Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

Martin Posch, Sarah Zohar, Siew Wan Hee, 2018, BMC Medical Research Methodology.

Approaches to sample size calculation for clinical trials in rare diseases

Martin Posch, Sarah Zohar, Siew Wan Hee, 2018, Pharmaceutical statistics.

Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data

Tim Friede, Nigel Stallard, Susan Todd, 2014, Pharmaceutical statistics.

Effect of Using the Same vs Different Order for Second Readings of Screening Mammograms on Rates of Breast Cancer Detection: A Randomized Clinical Trial.

Aileen Clarke, Nigel Stallard, Sian Taylor-Phillips, 2016, JAMA.

Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials

Nigel Stallard, Peter K. Kimani, 2018 .

Estimation after subpopulation selection in adaptive seamless trials

Nigel Stallard, Susan Todd, Peter K. Kimani, 2015, Statistics in medicine.

Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis

Richard Nicholas, Tim Friede, Nigel Stallard, 2010 .

Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations

Tim Friede, Nigel Stallard, Susan Todd, 2016, Biometrical journal. Biometrische Zeitschrift.

An adaptive two-arm clinical trial using early endpoints to inform decision making: design for a study of sub-acromial spacers for repair of rotator cuff tendon tears

Nigel Stallard, Martin Underwood, Nick Parsons, 2019, Trials.

Dose‐finding methods for Phase I clinical trials using pharmacokinetics in small populations

Moreno Ursino, Sarah Zohar, Tim Friede, 2017, Biometrical journal. Biometrische Zeitschrift.

Bayesian modelling of multivariate quantitative traits using seemingly unrelated regressions

Claudio J. Verzilli, Nigel Stallard, John C Whittaker, 2005, Genetic epidemiology.

A study of the efficacy and cost-effectiveness of MRSA screening and monitoring on surgical wards using a new, rapid molecular test (EMMS)

Ruth Davies, Nigel Stallard, Ala Szczepura, 2007, BMC Health Services Research.

The changing face of cardiovascular disease 2000-2012: An analysis of the world health organisation global health estimates data.

Nigel Stallard, Thomas Hamborg, N. Stallard, 2016, International journal of cardiology.

A Comparison of Methods for Treatment Selection in Seamless Phase II/III Clinical Trials Incorporating Information on Short-Term Endpoints

Tim Friede, Nigel Stallard, Susan Todd, 2015, Journal of biopharmaceutical statistics.