David Leys

发表

Frontiers in Biological Catalysis - Preface

Andrew W. Munro, David Leys, Emma Lloyd Raven, 2012 .

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition

Rebecca Beveridge, Mark D. White, Royston Goodacre, 2015, Nature.

P450 systems in Mycobacterium tuberculosis: structure, function and drug targeting

Andrew W. Munro, David Leys, A. Munro, 2007 .

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides.

Nicholas J Turner, Mark S Dunstan, David Leys, 2017, Angewandte Chemie.

Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode*

Andrew W Munro, David Leys, A. Munro, 2006, Journal of Biological Chemistry.

Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation.

Hanno Sjuts, Mark S Dunstan, David Leys, 2015, Acta crystallographica. Section D, Biological crystallography.

A microbial platform for renewable propane synthesis based on a fermentative butanol pathway

Patrik R. Jones, Nigel S Scrutton, David Leys, 2015, Biotechnology for Biofuels.

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

Mark D. White, Royston Goodacre, Nigel S. Scrutton, 2015, Nature.

Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling

Adrian J Mulholland, Kara E Ranaghan, Jaswir Basran, 2006, Science.

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

Kang Lan Tee, Andrew W. Munro, David Leys, 2015, Proceedings of the National Academy of Sciences.

Structure and mechanism of an unusual malonate decarboxylase and related racemases.

Bernhard Hauer, Jason Micklefield, David Leys, 2008, Chemistry.

Channelling and formation of ‘active’ formaldehyde in dimethylglycine oxidase

Jaswir Basran, David Leys, N. Scrutton, 2003, The EMBO journal.

Terminal Alkenes from Acrylic Acid Derivatives via Non‐Oxidative Enzymatic Decarboxylation by Ferulic Acid Decarboxylases

David Leys, Kurt Faber, David A Parker, 2018, ChemCatChem.

Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases.

Bernhard Hauer, Jason Micklefield, David Leys, 2009, Angewandte Chemie.

Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium*

Andrew W. Munro, David Leys, Karl Fisher, 2014, The Journal of Biological Chemistry.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Nigel S Scrutton, Nicholas J Turner, Mark S Dunstan, 2017, Nature chemical biology.

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Nigel S Scrutton, David Leys, N. Scrutton, 2013, Chembiochem : a European journal of chemical biology.

Microbial Cytochromes P450

Andrew W. Munro, David Leys, A. Munro, 2015 .

Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Å Reveals Novel Features of Cytochrome P450*

Malcolm D. Walkinshaw, Stephen K. Chapman, Christopher G. Mowat, 2003, The Journal of Biological Chemistry.

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

Carlos G. Acevedo-Rocha, Adrian J. Mulholland, Manfred T. Reetz, 2018 .

Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1

Kenneth H. Nealson, David Leys, K. Nealson, 1999, Nature Structural Biology.

In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling

Mark S Dunstan, David Leys, M. Dunstan, 2011, Molecular Cancer Therapeutics.

The TB structural genomics consortium: providing a structural foundation for drug discovery.

Shekhar C Mande, Tom Alber, David Eisenberg, 2002, Current drug targets. Infectious disorders.

Regioselective para‐Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase

Georg Steinkellner, Karl Gruber, Fahmi Himo, 2017, Angewandte Chemie.

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

Mark S. Dunstan, Nicholas J. Turner, David Leys, 2017, Scientific Reports.

Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species.

Mark S Dunstan, Jason Micklefield, David Leys, 2014, Journal of the American Chemical Society.