Marta Filizola

发表

Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model

Davide Provasi, Kristen A. Marino, Diego Prada-Gracia, 2016, PLoS Comput. Biol..

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

Michel Bouvier, Susan R. George, Jonathan A. Javitch, 2007, BMC Bioinformatics.

Advances in the development and application of computational methodologies for structural modeling of G-protein-coupled receptors

Marta Filizola, Juan Carlos Mobarec, M. Filizola, 2008, Expert opinion on drug discovery.

Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer

Marta Filizola, Simon X. Wang, Harel Weinstein, 2006, J. Comput. Aided Mol. Des..

Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques

Davide Provasi, Marta Camacho-Artacho, Marta Filizola, 2011, PLoS Comput. Biol..

Global physicochemical properties as activity discriminants for the mGluR1 subtype of metabotropic glutamate receptors

Marta Filizola, Hugo O. Villar, Silvina M. Tasso, 2001, J. Comput. Chem..

Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis

Davide Provasi, Marta Filizola, Xiaohu Hu, 2019, PLoS Comput. Biol..

Preferred Supramolecular Organization and Dimer Interfaces of Opioid Receptors from Simulated Self-Association

Davide Provasi, Marta Filizola, Jennifer M. Johnston, 2015, PLoS Comput. Biol..

BUNDLE: A program for building the transmembrane domains of G-protein-coupled receptors

Juan Jesús Pérez, Marta Filizola, Maria Cartenì-Farina, 1998, J. Comput. Aided Mol. Des..

Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

Marta Filizola, Paola Bisignano, Yi Shang, 2015, J. Chem. Inf. Model..

TRAJELIX: A Computational Tool for the Geometric Characterization of Protein Helices During Molecular Dynamics Simulations

Mihaly Mezei, Marta Filizola, M. Mezei, 2006, J. Comput. Aided Mol. Des..

Differentiation of δ, μ, and κ opioid receptor agonists based on pharmacophore development and computed physicochemical properties

Marta Filizola, Hugo O. Villar, Gilda H. Loew, 2001, J. Comput. Aided Mol. Des..

Modeling activated states of GPCRs: the rhodopsin template

Marta Filizola, Lucy Skrabanek, Masha Y. Niv, 2007, J. Comput. Aided Mol. Des..

Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand

Barry S. Coller, Jihong Li, Marta Filizola, 2012, Journal of Computer-Aided Molecular Design.

Assessing the Relative Stability of Dimer Interfaces in G Protein-Coupled Receptors

Hao Wang, Davide Provasi, Marta Filizola, 2012, PLoS Comput. Biol..

Grand opening of structure-guided design for novel opioids.

Marta Filizola, Lakshmi A Devi, L. Devi, 2013, Trends in pharmacological sciences.

Chapter 21:Investigating Mechanisms of Ligand Recognition, Activation and Oligomerization in GPCRs Using Enhanced Molecular Dynamics Methods

Marta Filizola, Jennifer M. Johnston, 2011 .

Modeling activated states of GPCRs: the rhodopsin template

Marta Filizola, Lucy Skrabanek, Masha Y. Niv, 2006, J. Comput. Aided Mol. Des..

Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening

Jonathan A. Javitch, Marta Filizola, Ana Negri, 2013, J. Chem. Inf. Model..

Oligomerization Domains of G Protein-Coupled Receptors

Jonathan A. Javitch, Marta Filizola, Harel Weinstein, 2005 .

Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers.

Marta Filizola, Harel Weinstein, H. Weinstein, 2002, Biopolymers.

Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?

Marta Filizola, M. Filizola, 2010, Life sciences.

Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics.

Davide Provasi, Marta Filizola, Andrea Bortolato, 2009, Biochemistry.

The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design.

Marta Filizola, Harel Weinstein, H. Weinstein, 2005, Current opinion in drug discovery & development.

Modern homology modeling of G-protein coupled receptors: which structural template to use?

Marta Filizola, Roberto Sanchez, Juan Carlos Mobarec, 2009, Journal of medicinal chemistry.

Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing‐out in β3 integrins

Davide Provasi, Marta Filizola, Marta Murcia, 2009, Proteins.

Molecular determinants of non-specific recognition of δ, μ, and κ opioid receptors

Marta Filizola, Hugo O. Villar, Gilda H. Loew, 2001 .

The Dynamic Process of Drug-GPCR Binding at Either Orthosteric or Allosteric Sites Evaluated by Metadynamics.

Davide Provasi, Marta Filizola, M. Filizola, 2015, Methods in molecular biology.

Influence of oligomerization on the dynamics of G‐protein coupled receptors as assessed by normal mode analysis

Marta Filizola, Masha Y Niv, M. Niv, 2008, Proteins.

Membrane Driven Spatial Organization of GPCRs

George Khelashvili, Marta Filizola, Jennifer M. Johnston, 2013, Scientific Reports.

Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity

Davide Provasi, Marta Filizola, Gianni de Fabritiis, 2017, Scientific Reports.

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability.

Davide Provasi, Miguel Biscaia, Marta Filizola, 2016, Journal of medicinal chemistry.

Identification of a serotonin/glutamate receptor complex implicated in psychosis

Graeme Milligan, Marta Filizola, Tony Yuen, 2008, Nature.

Evaluation of the iterative simulated annealing technique in conformational search of peptides

Marta Filizola, Juan J. Perez, Francesc J. Corcho, 2000 .

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

Michel Bouvier, Lakshmi Devi, Jonathan A. Javitch, 2007, Pharmacological Reviews.

Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics.

Davide Provasi, Marta Filizola, M. Filizola, 2010, Biophysical journal.

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Marta Filizola, Lei Shi, Juan Carlos Mobarec, 2008, The EMBO journal.

The study of G‐protein coupled receptor oligomerization with computational modeling and bioinformatics

Marta Filizola, Harel Weinstein, H. Weinstein, 2005, The FEBS journal.

G Protein-Coupled Receptors - Modeling and Simulation

Marta Filizola, M. Filizola, 2014, Advances in Experimental Medicine and Biology.

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

Davide Provasi, Arthur Christopoulos, Marta Filizola, 2016, ACS chemical biology.

Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors.

Marta Filizola, M. Filizola, Jennifer M Johnston, 2011, Current opinion in structural biology.

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.

Marta Filizola, Harel Weinstein, Jonathan A Javitch, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

Davide Provasi, Alexander D. MacKerell, Marta Filizola, 2011, Cell.

Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers

Davide Provasi, Jonathan A. Javitch, Marta Filizola, 2011, Biochemistry.

G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives

Martin J. Lohse, Graeme Milligan, Marta Filizola, 2014, Pharmacological Reviews.

How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways.

Davide Provasi, Marta Filizola, M. Filizola, 2016, Biochemistry.

Differential Stability of the Crystallographic Interfaces of Mu- and Kappa-Opioid Receptors

Marta Filizola, Jennifer M. Johnston, M. Filizola, 2014, PloS one.

3D modeling, ligand binding and activation studies of the cloned mouse δ, μ and κ opioid receptors

Marta Filizola, Liisa Laakkonen, Gilda H. Loew, 1999 .

Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method.

Marta Filizola, Harel Weinstein, Osvaldo Olmea, 2002, Protein engineering.