Amin Rostami-Hodjegan

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Complex patients - complex DDI: is there a straight way forward?

Amin Rostami-Hodjegan, 2015, Biopharmaceutics & drug disposition.

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Jill Barber, Bhagwat Prasad, Amin Rostami-Hodjegan, 2019, Clinical pharmacology and therapeutics.

PBPK models for the prediction of in vivo performance of oral dosage forms.

Martin Bergstrand, Xavier Pepin, Erik Sjögren, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice.

Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, 2019, Pharmacology & therapeutics.

Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, 2014, Drug Metabolism and Disposition.

Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)

Lu Gaohua, Masoud Jamei, Amin Rostami-Hodjegan, 2013 .

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine.

Sebastian Polak, Masoud Jamei, David B Turner, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Population-Based Mechanistic Prediction of Oral Drug Absorption

Sebastian Polak, Masoud Jamei, Amin Rostami-Hodjegan, 2009, The AAPS Journal.

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.

Masoud Jamei, Amin Rostami-Hodjegan, Geoffrey T Tucker, 2008, Current drug metabolism.

Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model.

Andrés Olivares-Morales, Leon Aarons, Adam S Darwich, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

Khaled Abduljalil, Amin Rostami-Hodjegan, A. Rostami-Hodjegan, 2014, Drug Metabolism and Disposition.

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Ruedi Aebersold, Tom Dunkley, Aleksandra Galetin, 2014, Pharmaceutical Research.

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Andrés Olivares-Morales, Leon Aarons, Aleksandra Galetin, 2013, Pharmaceutical Research.

Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption.

Sebastian Polak, Masoud Jamei, Malidi Ahamadi, 2012, Journal of pharmaceutical sciences.

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Masoud Jamei, Amin Rostami-Hodjegan, Iain Gardner, 2015, Front. Immunol..

The Simcyp population-based ADME simulator.

Kairui Feng, Masoud Jamei, Steve Marciniak, 2009, Expert opinion on drug metabolism & toxicology.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2017, Journal of pharmaceutical sciences.

Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin

Avijit Ghosh, Andrés Olivares-Morales, Leon Aarons, 2016, The AAPS Journal.

Assessment of inter-individual variability in predicted phenytoin clearance

Sebastian Polak, John O. Miners, Amin Rostami-Hodjegan, 2009, European Journal of Clinical Pharmacology.

Meta-Analysis of the Turnover of Intestinal Epithelia in Preclinical Animal Species and Humans

Umair Aslam, Adam S Darwich, Amin Rostami-Hodjegan, 2014, Drug Metabolism and Disposition.

Sex differences in the clearance of CYP3A4 substrates: exploring possible reasons for the substrate dependency and lack of consensus.

Amin Rostami-Hodjegan, Donald Mattison, D. Mattison, 2012, Current drug metabolism.

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

Amin Rostami-Hodjegan, A. Rostami-Hodjegan, E. Howgate, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, The AAPS Journal.

Systems Toxicology: Real World Applications and Opportunities

Gary R. Mirams, Imran Shah, Paul Jennings, 2017, Chemical research in toxicology.

Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease.

Aleksandra Galetin, Amin Rostami-Hodjegan, Rosalinde Masereeuw, 2019, Molecular pharmaceutics.

Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue

Aleksandra Galetin, Amin Rostami-Hodjegan, Brahim Achour, 2015, Drug Metabolism and Disposition.

In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

Amin Rostami-Hodjegan, Gordon Carlson, Brahim Achour, 2016, Drug Metabolism and Disposition.

The Simcyp® Population-based ADME Simulator

Kairui Feng, Masoud Jamei, Steve Marciniak, 2009 .

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

Hiroshi Yamazaki, Amin Rostami-Hodjegan, Chie Emoto, 2010, Current drug metabolism.

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Leon Aarons, Nikolaos Tsamandouras, Aleksandra Galetin, 2014, Pharmaceutical Research.