Theodore V. Tselios

发表

Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics

Haralambos Tzoupis, Golfo G. Kordopati, Anastassios N. Troganis, 2017, Journal of Computer-Aided Molecular Design.

Ligand Binding Determinants for Angiotensin II Type 1 Receptor from Computer Simulations

Arnau Cordomí, Leonardo Pardo, Theodore V. Tselios, 2013, J. Chem. Inf. Model..

Conformational Analysis of Aliskiren, a Potent Renin Inhibitor, Using High-Resolution Nuclear Magnetic Resonance and Molecular Dynamics Simulations

Panagiotis Zoumpoulakis, Theodore V. Tselios, Minos-Timotheos Matsoukas, 2011, J. Chem. Inf. Model..

Conformational analysis of the ΜΒΡ83–99 (Phe91) and ΜΒΡ83–99 (Tyr91) peptide analogues and study of their interactions with the HLA-DR2 and human TCR receptors by using Molecular Dynamics

Constantinos Potamitis, Simona Golic Grdadolnik, Thomas M. Mavromoustakos, 2011, J. Comput. Aided Mol. Des..

Conformational studies of immunodominant myelin basic protein 1–11 analogues using NMR and molecular modeling

Vasso Apostolopoulos, Anastassios N. Troganis, Theodore V. Tselios, 2011, J. Comput. Aided Mol. Des..

Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP83–96) Epitope to Function as T-Cell Receptor Antagonists

Theodore V. Tselios, V. Apostolopoulos, J. Platts, 2017, International journal of molecular sciences.

Molecular dynamics at the receptor level of immunodominant myelin basic protein epitope 87-99 implicated in multiple sclerosis and its antagonists altered peptide ligands: triggering of immune response.

Theodore V. Tselios, J. Platts, A. Brancale, 2007, Journal of molecular graphics & modelling.

Recovery and quantification of a myelin oligodendrocyte glycoprotein peptide from rat plasma after protein precipitation.

Theodore V. Tselios, A. Vlamis-Gardikas, Christos Kontos, 2017, Analytical biochemistry.

Structural elucidation of Leuprolide and its analogues in solution: insight into their bioactive conformation

Vasso Apostolopoulos, Anastassios N. Troganis, Theodore V. Tselios, 2010, Amino Acids.

The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan.

Theodore V. Tselios, Tahsin F. Kellici, T. Mavromoustakos, 2014, Biochimica et biophysica acta.

Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: rational design, synthesis and biological evaluation

Theodore V. Tselios, J. Matsoukas, Konstantinos Kelaidonis, 2011, Amino Acids.

Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2.

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2008, Molecular immunology.

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

Theodore V. Tselios, M. Karin, H. Lassmann, 2011, Brain : a journal of neurology.

Refinement of the gonadotropin releasing hormone receptor I homology model by applying molecular dynamics.

Theodore V. Tselios, J. Platts, E. Mantzourani, 2019, Journal of molecular graphics & modelling.

Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties.

Theodore V. Tselios, G. Liapakis, T. Katsila, 2012, European journal of medicinal chemistry.

Mannosylated Linear and Cyclic Single Amino Acid Mutant Peptides Using a Small 10 Amino Acid Linker Constitute Promising Candidates Against Multiple Sclerosis

Theodore V. Tselios, V. Apostolopoulos, S. Day, 2015, Front. Immunol..

Immune responses of linear and cyclic PLP139-151 mutant peptides in SJL/J mice: peptides in their free state versus mannan conjugation.

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2014, Immunotherapy.

Design and synthesis of a cyclic double mutant peptide (cyclo(87-99)[A91,A96]MBP87-99) induces altered responses in mice after conjugation to mannan: implications in the immunotherapy of multiple sclerosis.

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2009, Journal of medicinal chemistry.

Synthesis and study of the electrophoretic behavior of mannan conjugates with cyclic peptide analogue of myelin basic protein using lysine-glycine linker.

Theodore V. Tselios, V. Apostolopoulos, N. Karamanos, 2005, Analytical biochemistry.

Antagonistic effects of human cyclic MBP(87-99) altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation.

Theodore V. Tselios, V. Apostolopoulos, S. Grdadolnik, 2002, Journal of medicinal chemistry.

Mannan-conjugated myelin peptides prime non-pathogenic Th1 and Th17 cells and ameliorate experimental autoimmune encephalomyelitis

Theodore V. Tselios, V. Apostolopoulos, H. Lassmann, 2015, Experimental Neurology.

A double mutation of MBP83–99 peptide induces IL-4 responses and antagonizes IFN-γ responses

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2008, Journal of Neuroimmunology.

Structure and function of the myelin proteins: current status and perspectives in relation to multiple sclerosis.

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2005, Current medicinal chemistry.

A novel synthetic luteinizing hormone-releasing hormone (LHRH) analogue coupled with modified β-cyclodextrin: insight into its intramolecular interactions.

Golfo G. Kordopati, Theodore V. Tselios, S. Grdadolnik, 2015, Biochimica et biophysica acta.

In Silico Drug Design: Non-peptide Mimetics for the Immunotherapy of Multiple Sclerosis.

Theodore V. Tselios, Haralambos Tzoupis, 2018, Methods in molecular biology.

Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

Theodore V. Tselios, H. Lassmann, W. Möbius, 2020, Frontiers in Immunology.

Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis

Theodore V. Tselios, L. Probert, M. Androutsou, 2022, Frontiers in Immunology.

Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis

Theodore V. Tselios, L. Probert, M. Androutsou, 2020, International journal of molecular sciences.

A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis

Golfo G. Kordopati, Theodore V. Tselios, Tahsin F. Kellici, 2017, Journal of biomolecular structure & dynamics.

Conjugation of a peptide to mannan and its confirmation by tricine sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

Theodore V. Tselios, V. Apostolopoulos, A. Vlamis-Gardikas, 2015, Analytical biochemistry.

The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation.

Theodore V. Tselios, H. Amenitsch, G. Mali, 2019, Biochimica et biophysica acta. Biomembranes.

Influenza A M2 Spans the Membrane Bilayer, Perturbs its Organization and Differentiates the Effect of Amantadine and Spiro[pyrrolidine-2,2'-adamantane] AK13 on Lipids

Theodore V. Tselios, H. Amenitsch, G. Mali, 2019 .

Development of PLGA Nanoparticles with a Glycosylated Myelin Oligodendrocyte Glycoprotein Epitope (MOG35-55) against Experimental Autoimmune Encephalomyelitis (EAE).

Theodore V. Tselios, U. Dianzani, N. Clemente, 2022, Molecular pharmaceutics.

Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer

Theodore V. Tselios, G. Liapakis, N. Kostomitsopoulos, 2011, Journal of Pharmacology and Experimental Therapeutics.

Use of the 2‐chlorotrityl chloride resin for microwave‐assisted solid phase peptide synthesis

Theodore V. Tselios, M. Androutsou, Kirsty E. High, 2015, Biopolymers.

Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on ανβ3 integrin expression

Theodore V. Tselios, E. Papadimitriou, M. S. Sajib, 2020, Angiogenesis.

Divergent and convergent synthesis of polymannosylated dibranched antigenic peptide of the immunodominant epitope MBP(83-99).

Theodore V. Tselios, M. Chelli, A. Papini, 2013, Bioorganic & medicinal chemistry.

Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis.

Theodore V. Tselios, V. Apostolopoulos, H. Kalbacher, 2015, European journal of medicinal chemistry.

Rational Design and Synthesis of a Potent Amide-Linked Cyclic Analogue of MBP87–99 Based on 2D-NMR Studies and Molecular Dynamics

Theodore V. Tselios, L. Probert, J. Matsoukas, 2001 .

Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

Theodore V. Tselios, J. Matsoukas, Konstantinos Kelaidonis, 2013, Molecules.

Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis.

Theodore V. Tselios, A. Vlamis-Gardikas, M. Androutsou, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Peptides as Therapeutic Agents or Drug Leads for Autoimmune, Hormone Dependent and Cardiovascular Diseases

Minos-Timotheos Matsoukas, Theodore V. Tselios, Theodore Tselios, 2008 .

A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis.

Simona Golic Grdadolnik, Theodore V. Tselios, Theodore Tselios, 2008, Bioorganic & medicinal chemistry.

Review cyclic peptides on a merry‐go‐round; towards drug design

Theodore V. Tselios, C. Simal, Minos-Timotheos Matsoukas, 2015, Biopolymers.

Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities.

Theodore V. Tselios, A. Cencič, D. Komiotis, 2008, European journal of medicinal chemistry.

Multiple Sclerosis: Immunopathology and Treatment Update

Theodore V. Tselios, V. Apostolopoulos, M. D. de Courten, 2017, Brain sciences.

Cyclic citrullinated MBP87-99 peptide stimulates T cell responses: Implications in triggering disease.

Theodore V. Tselios, V. Apostolopoulos, S. Day, 2017, Bioorganic & medicinal chemistry.

Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35-55 epitope implicated in multiple sclerosis.

Theodore V. Tselios, Mary-Patricia Yannakakis, C. Simal, 2016, Journal of molecular graphics & modelling.

Rational Design and Synthesis of Altered Peptide Ligands based on Human Myelin Oligodendrocyte Glycoprotein 35–55 Epitope: Inhibition of Chronic Experimental Autoimmune Encephalomyelitis in Mice

Theodore V. Tselios, J. Matsoukas, V. Tseveleki, 2014, Molecules.

Altered peptide ligands of myelin basic protein (MBP87–99) conjugated to reduced mannan modulate immune responses in mice

Theodore V. Tselios, V. Apostolopoulos, N. Grigoriadis, 2009, Immunology.

NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations.

Theodore V. Tselios, A. Bonvin, N. V. van Nuland, 2004, European journal of biochemistry.

Gonadotropin Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development.

Theodore V. Tselios, Haralambos Tzoupis, M. Androutsou, 2019, Current medicinal chemistry.

Immunotherapy for multiple sclerosis: basic insights for new clinical strategies.

Theodore V. Tselios, A. Mouzaki, P. Papathanassopoulos, 2004, Current neurovascular research.

Round and round we go: cyclic peptides in disease.

Vasso Apostolopoulos, Minos-Timotheos Matsoukas, Theodore V. Tselios, 2006, Current medicinal chemistry.

Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease.

Theodore V. Tselios, V. Apostolopoulos, D. Vynios, 2008, Journal of medicinal chemistry.

Neuronal IκB Kinase β Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System1

Theodore V. Tselios, M. Karin, H. Lassmann, 2009, The Journal of Immunology.

Kinase Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System 1

Theodore V. Tselios, M. Karin, H. Lassmann, 2009 .

Design of novel cyclic altered peptide ligands of myelin basic protein MBP83-99 that modulate immune responses in SJL/J mice.

Theodore V. Tselios, V. Apostolopoulos, J. Matsoukas, 2008, Journal of medicinal chemistry.

Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP85-99) epitope: Towards selective immunosuppression.

Theodore V. Tselios, V. Apostolopoulos, A. Vlamis-Gardikas, 2018, European journal of medicinal chemistry.

NMR structural elucidation of myelin basic protein epitope 83–99 implicated in multiple sclerosis

Theodore V. Tselios, J. Matsoukas, G. Spyroulias, 2010, Amino Acids.

A Combined Computational and Structural Approach into Understanding the Role of Peptide Binding and Activation of the Melanocortin Receptor 4.

Minos-Timotheos Matsoukas, Theodore V. Tselios, Julian Zachmann, 2020, Journal of chemical information and modeling.

Microwave-assisted solid-phase peptide synthesis of the 60–110 domain of human pleiotrophin on 2-chlorotrityl resin

Theodore V. Tselios, E. Papadimitriou, J. Matsoukas, 2011, Amino Acids.

Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.

Vasso Apostolopoulos, Francesco Lolli, Theodore V. Tselios, 2005, Journal of medicinal chemistry.

A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87–99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis

Theodore V. Tselios, L. Probert, V. Tseveleki, 2018, Molecules.

Putative bioactive conformations of amide linked cyclic myelin basic protein peptide analogues associated with experimental autoimmune encephalomyelitis.

Georgios A. Dalkas, Theodore V. Tselios, J. Matsoukas, 2007, Journal of medicinal chemistry.

The Influence of Single Nucleotide Polymorphisms on Vitamin D Receptor Protein Levels and Function in Chronic Liver Disease

Theodore V. Tselios, Haralampos Tzoupis, M. Rodi, 2023, International journal of molecular sciences.

Spontaneous and inducible CD8 T cell lesions in the brain and spinal cord of HLA-DR15-positive MS PBMC humanized mice

Theodore V. Tselios, M. Anagnostouli, L. Probert, 2023, bioRxiv.

Molecular investigation of artificial and natural sweeteners as potential anti-inflammatory agents

Theodore V. Tselios, T. Mavromoustakos, Demeter Tzeli, 2021, Journal of biomolecular structure & dynamics.

Mannan-conjugated myelin peptides prime non-pathogenic Th1 and Th17 cells and ameliorate experimental autoimmune encephalomyelitis

Theodore V. Tselios, V. Apostolopoulos, H. Lassmann, 2015, Experimental Neurology.

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

Theodore V. Tselios, M. Karin, H. Lassmann, 2011, Brain : a journal of neurology.

Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides.

Theodore V. Tselios, L. Probert, G. Moore, 2000, Bioorganic & medicinal chemistry.

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.

T Mavromoustakos, Theodore V. Tselios, L. Probert, 2000, Bioorganic & medicinal chemistry letters.