Laurent Meijer

发表

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor.

Vassilios Myrianthopoulos, Emmanuel Mikros, Sofia Vasilakaki, 2018, Future medicinal chemistry.

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Doris Marko, Ralph Hoessel, Gerhard Eisenbrand, 1999, Nature Cell Biology.

1‐Azakenpaullone Is a Selective Inhibitor of Glycogen Synthase Kinase‐3β.

Laurent Meijer, Conrad Kunick, L. Meijer, 2004 .

Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.

Philippe Bernard, Florence Popowycz, Laurent Meijer, 2009, Journal of medicinal chemistry.

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]

Lin Tang, Hervé Galons, Olivier Lozach, 2005, Journal of Biological Chemistry.

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

Poonsakdi Ploypradith, Olivier Lozach, Laurent Meijer, 2008, Marine drugs.

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials.

Laurent Meijer, L. Meijer, E. Raymond, 2003, Accounts of chemical research.

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.

Jane Endicott, Laurent Meijer, Virginie Thomas, 2003, Journal of medicinal chemistry.

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Olivier Lozach, Laurent Meijer, Thierry Besson, 2006, Bioorganic & medicinal chemistry.

A Novel Interaction Between HER2/neu and Cyclin E in Breast Cancer

Yan Liu, Kelly K. Hunt, Laurent Meijer, 2010, Oncogene.

Mechanism of CDK5/p25 binding by CDK inhibitors.

Andrea Musacchio, Li-Huei Tsai, Laurent Meijer, 2005, Journal of medicinal chemistry.

Sequential Dephosphorylation of p34cdc2 on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition*

Laurent Meijer, L. Meijer, A. Borgne, 1996, The Journal of Biological Chemistry.

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.

Olivier Lozach, Laurent Meijer, L. Meijer, 2005, Journal of medicinal chemistry.

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

Daniel Cappel, Vassilios Myrianthopoulos, Emmanuel Mikros, 2012, ACS medicinal chemistry letters.

Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography.

Laurent Meijer, L. Meijer, M. Knockaert, 2002, Biochemical pharmacology.

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

Hervé Galons, Laurent Meijer, Olivier Leclercq, 2016, Antimicrobial Agents and Chemotherapy.

Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents.

Laurent Meijer, L. Meijer, 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors.

Laurent Meijer, Virginie Thomas, Conrad Kunick, 2004, Biochimica et biophysica acta.

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

Laurent Meijer, L. Meijer, U. Schulze-Gahmen, 2005, Journal of medicinal chemistry.

3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.

Prokopios Magiatis, Olivier Lozach, Laurent Meijer, 2006, Journal of medicinal chemistry.

Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Rick Gussio, Laurent Meijer, Conrad Kunick, 2005, Chembiochem : a European journal of chemical biology.

Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E.

Laurent Meijer, L. Meijer, K. Keyomarsi, 2011, Cancer research.

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

Laurent Meijer, Jean-Philippe Semblat, L. Meijer, 2011, Microbiology.

Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast

Matthias Peter, Laurent Meijer, Yves Barral, 2005, The EMBO journal.

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

Laurent Meijer, Jeffry D Madura, L. Meijer, 2011, Bioorganic & medicinal chemistry.

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

Laurent Meijer, L. Meijer, M. Leost, 2004, Bioorganic & medicinal chemistry letters.

Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)

Laurent Meijer, Cun Zhuang, Takashi Mizuno, 1999 .

Protein kinases as drug targets in parasitic protozoa.

Laurent Meijer, L. Meijer, J. Mottram, 2002, Trends in parasitology.

Activation of a Plasmodium falciparum cdc2-related Kinase by Heterologous p25 and Cyclin H

Barbara Kappes, Laurent Meijer, L. Meijer, 2000, The Journal of Biological Chemistry.

Pharmacological inhibitors of cyclin-dependent kinases.

Paul Greengard, Laurent Meijer, P. Greengard, 2002, Trends in pharmacological sciences.