Jon T. Sack

发表

A strategy to measure electrophysiological changes with photoacoustic imaging (Conference Presentation)

Laura Marcu, Lin Tian, Rebecka J. Sepela, 2017, BiOS.

A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization

Stephen F. Kingsmore, James S. Trimmer, Jon T. Sack, 2015, The Journal of general physiology.

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

Helgi I. Ingólfsson, Jon T. Sack, Katherine C. Hall, 2014, ACS chemical biology.

Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain

Jon T. Sack, V. Yarov-Yarovoy, H. Wulff, 2022, bioRxiv.

Na+ channel function, regulation, structure, trafficking and sequestration

Jon T. Sack, R. Aldrich, W. Catterall, 2015, The Journal of physiology.

Taming unruly chloride channel inhibitors with rational design

Rebecka J. Sepela, Jon T. Sack, 2018, Proceedings of the National Academy of Sciences.

Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.

Helgi I. Ingólfsson, Jon T. Sack, R. Aldrich, 2018, Biochemistry.

What keeps Kv channels small? The molecular physiology of modesty

Jon T. Sack, J. T. Sack, D. C. Tilley, 2015, The Journal of general physiology.

Antibody-guided photoablation of voltage-gated potassium currents

Jon T. Sack, J. Trimmer, N. Stephanopoulos, 2013, The Journal of general physiology.

Mechanism of use-dependent Kv2 channel inhibition by RY785

Jon T. Sack, J. Sack, M. Marquis, 2022, The Journal of general physiology.

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

Jon T. Sack, J. Hell, J. Nerbonne, 2014, Genes, brain, and behavior.

Handbook of Ion Channels

Jon T. Sack, J. Sack, K. Eum, 2023 .

Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline

Kevin R. DeMarco, Jon T. Sack, J. Fettinger, 2021, Journal of molecular and cellular cardiology.

Optical measurement of endogenous ion channel voltage sensor activation in tissue

Rebecka J. Sepela, Jon T. Sack, B. Cohen, 2019, bioRxiv.

Structural modeling of hERG channel–drug interactions using Rosetta

Kevin R. DeMarco, Jon T. Sack, V. Yarov-Yarovoy, 2023, Frontiers in pharmacology.

Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker

Jon T. Sack, C. Clancy, Kazuharu Furutani, 2022, Molecular Pharmacology.

Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening

Jon T. Sack, C. Clancy, Kazuharu Furutani, 2022, bioRxiv.

Structural modeling of the hERG potassium channel and associated drug interactions

Kevin R. DeMarco, Jon T. Sack, V. Yarov-Yarovoy, 2021, bioRxiv.

The envenomation of general physiology throughout the last century

Jon T. Sack, 2017, The Journal of general physiology.

EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues

Rebecka J. Sepela, Jon T. Sack, B. Cohen, 2021, The Journal of general physiology.

Fluorescent toxins as ion channel activity sensors.

Jon T. Sack, B. Cohen, R. Stewart, 2021, Methods in enzymology.

Characterization of a Novel Gastropod Toxin (6-Bromo-2-mercaptotryptamine) That Inhibits Shaker K Channel Activity*

Jon T. Sack, J. Sweedler, R. A. Jockusch, 2003, Journal of Biological Chemistry.

Na+ channel regulation, structure, trafficking and sequestration

Jon T. Sack, R. Aldrich, W. Catterall, 2015 .

The AMIGO1 adhesion protein activates Kv2.1 voltage sensors

Rebecka J. Sepela, Jon T. Sack, B. Cohen, 2021, bioRxiv.

Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway

Jon T. Sack, R. Aldrich, J. Sack, 2006, The Journal of General Physiology.

The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation

Jon T. Sack, L. Chao, Juan M. Angueyra, 2018, The Journal of general physiology.

Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells*

Jon T. Sack, J. Trimmer, J. Sack, 2015, The Journal of Biological Chemistry.

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Jon T. Sack, C. Dupre, B. Cohen, 2014, Proceedings of the National Academy of Sciences.

A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway

Jon T. Sack, R. Aldrich, W. Gilly, 2004, The Journal of general physiology.

Optical measurement of voltage sensing by endogenous ion channels

Rebecka J. Sepela, Jon T. Sack, B. Cohen, 2019 .

Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels

Jon T. Sack, J. Trimmer, A. King, 2018, Molecular biology of the cell.

Computational design of peptides to target NaV 1 . 7 channel with high 1 potency and selectivity for the treatment of pain 2 3

Jon T. Sack, V. Yarov-Yarovoy, P. T. Nguyen, 2022 .

A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway

Jon T. Sack, R. Aldrich, W. Gilly, 2004, The Journal of general physiology.

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

Jon T. Sack, V. Yarov-Yarovoy, K. Gupta, 2015, eLife.

An imaging method to measure conformational changes of voltage sensors of endogenous ion channels in tissue

Rebecka J. Sepela, Jon T. Sack, B. Cohen, 2019 .

Organizing neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels

Jon T. Sack, J. Trimmer, A. King, 2018, bioRxiv.

Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

Jon T. Sack, Y. Kurachi, K. Tsumoto, 2019, The Journal of general physiology.