Horst Kessler

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Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides

Gerhard Müller, Marion Gurrath, Horst Kessler, 1994, J. Comput. Aided Mol. Des..

Impact of order and disorder in RGD nanopatterns on cell adhesion.

Joachim P Spatz, Ralf Kemkemer, Horst Kessler, 2009, Nano letters.

Structure Refinement of Cyclosporin A in Chloroform by Using RDCs Measured in a Stretched PDMS‐Gel

Horst Kessler, Burkhard Luy, Murray Coles, 2005, Chembiochem : a European journal of chemical biology.

Two‐Dimensional NMR Spectroscopy: Background and Overview of the Experiments [New Analytical Methods (36)]

Horst Kessler, Christian Griesinger, C. Griesinger, 1988 .

Specific integrin labeling in living cells using functionalized nanocrystals.

Horst Kessler, Oliver Lieleg, Andreas R Bausch, 2007, Small.

Chemical conjugation of linear and cyclic RGD moieties to a recombinant elastin-mimetic polypeptide--a versatile approach towards bioactive protein hydrogels.

Horst Kessler, Andreas Junger, H. Kessler, 2008, Macromolecular bioscience.

Radiolabeled αvβ3 Integrin Antagonists: A New Class of Tracers for Tumor Targeting

Horst Kessler, Markus Schwaiger, Hans-Jürgen Wester, 1999 .

N-methylated cyclic RGD peptides as highly active and selective αvβ3 integrin antagonists

Horst Kessler, Günter Hölzemann, S. Goodman, 1999 .

Activation of integrin function by nanopatterned adhesive interfaces.

Joachim P Spatz, Horst Kessler, Marco Arnold, 2004, Chemphyschem : a European journal of chemical physics and physical chemistry.

Intestinal permeability of cyclic peptides: common key backbone motifs identified.

Horst Kessler, Jayanta Chatterjee, Chaim Gilon, 2012, Journal of the American Chemical Society.

Automated backbone assignment of labeled proteins using the threshold accepting algorithm

Horst Kessler, Christian Schwarz, Christian Schwarz, 1998, Journal of biomolecular NMR.

Conformational Analysis of Drugs by Nuclear Magnetic Resonance Spectroscopy

Horst Kessler, Burkhard Luy, H. Kessler, 2007 .

Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns.

Horst Kessler, Michael Bruns, Doris Wedlich, 2008, Biomaterials.

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

Horst Kessler, H. Kessler, F. Rechenmacher, 2010, Anti-cancer agents in medicinal chemistry.

Peptide conformations. 46. Conformational analysis of a superpotent cytoprotective cyclic somatostatin analog

Horst Kessler, Christian Griesinger, Jan W. Bats, 1988 .

N-methylation of peptides and proteins: an important element for modulating biological functions.

Horst Kessler, Jayanta Chatterjee, H. Kessler, 2013, Angewandte Chemie.

Docking studies on αvβ3 integrin ligands: Pharmacophore refinement and implications for drug design

Horst Kessler, Ettore Novellino, Luciana Marinelli, 2003 .

Improving oral bioavailability of cyclic peptides by N-methylation.

Horst Kessler, Michael Weinmüller, H. Kessler, 2017, Bioorganic & medicinal chemistry.

Positron Emission Tomography Using [18F]Galacto-RGD Identifies the Level of Integrin αvβ3 Expression in Man

Horst Kessler, Oliver Schnell, Anca L. Grosu, 2006, Clinical Cancer Research.

Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization.

Horst Kessler, Rudolf Hartmann, M. Wendeler, 2004, Protein expression and purification.

WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization*

Horst Kessler, Petr Pancoska, C. Klein, 2006, Journal of Biological Chemistry.

Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.

Horst Kessler, Ettore Novellino, Luciana Marinelli, 2003, Journal of medicinal chemistry.

Peptoids—A New Approach to the Development of Pharmaceuticals

Horst Kessler, H. Kessler, 1993 .

First 18F-Labeled Tracer Suitable for Routine Clinical Imaging of sst Receptor-Expressing Tumors Using Positron Emission Tomography

Horst Kessler, Margret Schottelius, Markus Schwaiger, 2004, Clinical Cancer Research.

Design and chemical synthesis of integrin ligands.

Horst Kessler, H. Kessler, D. Heckmann, 2007, Methods in enzymology.

Orientational properties of stretched polystyrene gels in organic solvents and the suppression of their residual 1H NMR signals.

Horst Kessler, Burkhard Luy, Julien Furrer, 2005, Journal of the American Chemical Society.

Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.

Johannes Buchner, Horst Kessler, Gerd Schmitz, 2010, Molecular cell.

The Redox Potential of Selenocystine in Unconstrained Cyclic Peptides

Horst Kessler, Luis Moroder, H. Kessler, 1997 .

Cooperativity in adhesion cluster formation during initial cell adhesion.

Joachim P Spatz, Horst Kessler, C. Selhuber-Unkel, 2008, Biophysical journal.

Stereoisomeric Peptide Libraries and Peptidomimetics for Designing Selective Inhibitors of the αvβ3 Integrin for a New Cancer Therapy

Horst Kessler, H. Kessler, R. Haubner, 1997 .

The N-terminal domain of p53 is natively unfolded.

Johannes Buchner, Horst Kessler, C. Klein, 2003, Journal of molecular biology.

Multiple N-methylation by a designed approach enhances receptor selectivity.

Horst Kessler, Luciana Marinelli, Jayanta Chatterjee, 2007, Journal of medicinal chemistry.

Peptide conformations. Part 31. The conformation of cyclosporin a in the crystal and in solution

Armin Widmer, Horst Kessler, Hartmut Oschkinat, 1985 .

An improved technique for correlating backbone amide protons with 15N and Hα protons (HN(CA)H) in isotopically enriched proteins

Horst Kessler, H. Kessler, J. Balbach, 1992 .

Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer1

Ernst J. Rummeny, Vasilis Ntziachristos, Horst Kessler, 2016, Neoplasia.

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly.

Joachim P Spatz, Horst Kessler, H. Kessler, 2006, European journal of cell biology.

Novel Solid-Phase Synthesis of Azapeptides and Azapeptoides via Fmoc-Strategy and Its Application in the Synthesis of RGD-Mimetics

Horst Kessler, Günter Hölzemann, S. Goodman, 1999 .

Carbohydrate-Based Mimetics in Drug Design: Sugar Amino Acids and Carbohydrate Scaffolds

Horst Kessler, H. Kessler, Elisabeth Lohof, 2002 .

NMR-based screening: a powerful tool in fragment-based drug discovery.

Horst Kessler, Murray Coles, H. Kessler, 2007 .

A Three‐State Mechanism of Integrin Activation and Signal Transduction for Integrin αvβ3

Horst Kessler, Robert Günther, K. Gottschalk, 2002 .

Systematic optimization of a lead‐structure identities for a selective short peptide agonist for the human orphan receptor BRS‐3

Horst Kessler, Dirk Weber, Jochen Antel, 2002, Journal of peptide science : an official publication of the European Peptide Society.

NMR-based screening technologies.

Horst Kessler, Murray Coles, H. Kessler, 2003, Drug discovery today.

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation.

Horst Kessler, S. Goodman, H. Kessler, 2003, Chemistry.

Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces

Horst Kessler, Joachim P. Spatz, Patrick Herre, 2014, Interface Focus.

Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.

Horst Kessler, Gjermund Henriksen, Margret Schottelius, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

Benjamin Geiger, Horst Kessler, Hans-Jürgen Wester, 2017, Scientific Reports.

Improvement of drug-like properties of peptides: the somatostatin paradigm

Horst Kessler, Chaim Gilon, Oded Ovadia, 2010, Expert opinion on drug discovery.

Peptide conformations. Part 30. Assignment of the 1H‐, 13C‐, and 15N‐NMR spectra of cyclosporin A in CDCl3 and C6D6 by a combination of homo‐ and heteronuclear two‐dimensional techniques

Horst Kessler, Hartmut Oschkinat, H. Kessler, 1985 .

Nonpeptidic αv β3 Integrin Antagonist Libraries: On-Bead Screening and Mass Spectrometric Identification without Tagging.

Horst Kessler, Günter Hölzemann, S. Goodman, 2001, Angewandte Chemie.

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond.

Horst Kessler, H. Kessler, Claudia Dahmen, 2003, Biomaterials.

Characterization of human saposins by NMR spectroscopy.

Horst Kessler, Konrad Sandhoff, Michael John, 2006 .

Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation.

Joachim P Spatz, Horst Kessler, Theobald Lohmüller, 2010, Langmuir : the ACS journal of surfaces and colloids.

Cell interactions with hierarchically structured nano-patterned adhesive surfaces.

Benjamin Geiger, Joachim P Spatz, Horst Kessler, 2009, Soft matter.

Hsp90 is regulated by a switch point in the C‐terminal domain

Johannes Buchner, Horst Kessler, Jürgen Beck, 2009, EMBO reports.

Mimicking cellular environments by nanostructured soft interfaces.

Joachim P Spatz, Horst Kessler, Jinghuan Huang, 2007, Nano letters.

Solid-Phase Synthesis of a Nonpeptide RGD Mimetic Library: New Selective αvβ3 Integrin Antagonists

Horst Kessler, Günter Hölzemann, S. Goodman, 2001 .

Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces.

Joachim P Spatz, Horst Kessler, H. Kessler, 2007, Biomaterials.

Nomenclature for Intramolecular Exchange Processes

Horst Kessler, Ernest L. Eliel, Gerhard Binsch, 1971 .

Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging

Ute Resch-Genger, Jutta Pauli, Horst Kessler, 2011, Molecular imaging.

Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing.

Benjamin Geiger, Joachim P Spatz, Horst Kessler, 2008, Nano letters.

Guiding plant virus particles to integrin-displaying cells.

Horst Kessler, Qian Wang, Nicole F Steinmetz, 2012, Nanoscale.

Noninvasive Imaging of αvβ3 Integrin Expression Using 18F-labeled RGD-containing Glycopeptide and Positron Emission Tomography

Sibylle Ziegler, Horst Kessler, Wolfgang A. Weber, 2001 .

Diffusion NMR Spectroscopy: Folding and Aggregation of Domains in p53

Horst Kessler, A. Dehner, H. Kessler, 2005, Chembiochem : a European journal of chemical biology.

Reinvestigation of the Conformation of Cyclosporin A in Chloroform

Horst Kessler, Matthias Köck, Matthias Gehrke, 1990 .

Phosphorus NMR spectroscopy as a versatile tool for compound library screening.

Horst Kessler, H. Kessler, Florian Manzenrieder, 2008, Angewandte Chemie.

Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins

Horst Kessler, Günter Hölzemann, S. Goodman, 2002 .

Conformation and Biological Activity of Cyclic Peptides

Horst Kessler, H. Kessler, 1982 .

Scalar Coupling Constants—Their Analysis and Their Application for the Elucidation of Structures

Horst Kessler, Dale F. Mierke, H. Kessler, 1995 .

pH-dependent dimerization and salt-dependent stabilization of the N-terminal domain of spider dragline silk--implications for fiber formation.

Thomas Scheibel, Horst Kessler, H. Kessler, 2011, Angewandte Chemie.

Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands

Horst Kessler, H. Kessler, Timo Weide, 2006 .

Cyclic RGD Peptides Containing β-Turn Mimetics

Horst Kessler, Günter Hölzemann, S. Goodman, 1996 .

The Cyclic Cystine Ladder of Theta‐Defensins as a Stable, Bifunctional Scaffold: A Proof‐of‐Concept Study Using the Integrin‐Binding RGD Motif.

Horst Kessler, Petar Stupar, David J Craik, 2014, Chembiochem : a European journal of chemical biology.

Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.

Benjamin Geiger, Horst Kessler, Elisabetta Ada Cavalcanti-Adam, 2007, Biophysical journal.

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.

Horst Kessler, Raz Jelinek, Jayanta Chatterjee, 2008, Angewandte Chemie.

Impact of local versus global ligand density on cellular adhesion.

Joachim P Spatz, Horst Kessler, C. Selhuber-Unkel, 2011, Nano letters.

A conserved spider silk domain acts as a molecular switch that controls fibre assembly

Thomas Scheibel, Horst Kessler, Murray Coles, 2010, Nature.

Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure.

Horst Kessler, Eberhardt Herdtweck, Ettore Novellino, 2014, Chemistry.

The structures of integrins and integrin-ligand complexes: implications for drug design and signal transduction.

Horst Kessler, K. Gottschalk, H. Kessler, 2002, Angewandte Chemie.

Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD

Horst Kessler, Wolfgang A Weber, Ambros J Beer, 2005, PLoS medicine.