Laura C. Greaves

发表

Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis

Sean L. Preston, Sac McDonald, Dahmane Oukrif, 2005 .

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial DNA mutations in human colonic crypt stem cells.

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2003, The Journal of clinical investigation.

A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2009, Stem cells.

SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Irving L. Weissman, Laura C. Greaves, Rudolf Jaenisch, 2015, Cell stem cell.

The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential

Laura C. Greaves, Robert W. Taylor, R. Rodenburg, 2013, Human molecular genetics.

Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies

Jesper Bo Nielsen, Laura C. Greaves, Simon C. Wilkinson, 2006, International archives of occupational and environmental health.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Laura C. Greaves, Caroline L. Wilson, C. Lawless, 2014, Nature Communications.

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2010, Experimental Gerontology.

Mitochondrial DNA and disease

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2012, The Journal of pathology.

Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

Laura C. Greaves, R. Berlinguer-Palmini, M. Walker, 2022, Molecular metabolism.

ZMA, Taylor RW, Vila-Sanjurjo A. The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease. Mitochondrion 2015, 25, 17-27

Laura C. Greaves, Robert W. Taylor, R. Lightowlers, 2015 .

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Laura C. Greaves, N. LeBrasseur, R. Berlinguer-Palmini, 2019, The EMBO journal.

Length-independent telomere damage drives cardiomyocyte senescence

Laura C. Greaves, N. LeBrasseur, R. Berlinguer-Palmini, 2018, bioRxiv.

Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

Laura C. Greaves, D. Turnbull, N. Clarke, 2022, Scientific Reports.

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency

Laura C. Greaves, Robert W. Taylor, A. Mourier, 2018, The Journal of pathology.

Mitochondrial DNA mutations in ageing and cancer

Laura C. Greaves, Anna L M Smith, Julia C Whitehall, 2022, Molecular oncology.

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2015, Clinical science.

Mitochondrial DNA mutations in human disease

Laura C. Greaves, Robert W. Taylor, Robert W. Taylor, 2006, IUBMB life.

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2010, Investigative ophthalmology & visual science.

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Laura C. Greaves, D. Turnbull, T. Su, 2018, Genes.

Mitochondrial DNA mutations and ageing.

Laura C. Greaves, D. Turnbull, 2009, Biochimica et biophysica acta.

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Laura C. Greaves, D. Turnbull, A. Laude, 2020, Scientific Reports.

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2014, PLoS genetics.

Locating the stem cell niche and tracing hepatocyte lineages in human liver

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2009, Hepatology.

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

Laura C. Greaves, A. Bratić, N. Larsson, 2016, Cell reports.

Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2020, Nature Cancer.

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2017, Cell reports.

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

Laura C. Greaves, D. Turnbull, T. Kirkwood, 2018, EBioMedicine.

Mitochondria are required for pro‐ageing features of the senescent phenotype

Laura C. Greaves, Glyn Nelson, Satomi Miwa, 2016, The EMBO journal.

Aberrant mitochondrial function in ageing and cancer

Laura C. Greaves, Julia C. Whitehall, 2019, Biogerontology.

Clonal Expansion in the Human Gut: Mitochondrial DNA Mutations Show Us the Way

Laura C. Greaves, D. Turnbull, N. Wright, 2006, Cell cycle.

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells

Laura C. Greaves, D. Turnbull, C. Robson, 2011, The Journal of pathology.

Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2008, Gastroenterology.

Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition

Laura C. Greaves, J. Petrosino, D. Turnbull, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2018, The Journal of pathology.

Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

Laura C. Greaves, Robert W. Taylor, F. Muntoni, 2014, The Journal of experimental medicine.

Mitochondrial DNA Mutations and Aging

Laura C. Greaves, D. Turnbull, K. J. Krishnan, 2007, Annals of the New York Academy of Sciences.

The rise and rise of mitochondrial DNA mutations

Laura C. Greaves, D. Turnbull, C. Lawless, 2020, Open Biology.

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease

Laura C. Greaves, Robert W. Taylor, R. Lightowlers, 2015, Mitochondrion.

The presence of highly disruptive 16 S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease Running Title : Role of the mitoribosomal large subunit rRNA in human disease

Laura C. Greaves, Robert W. Taylor, R. Lightowlers, 2015 .

The ageing mitochondrial genome

Laura C. Greaves, D. Turnbull, K. J. Krishnan, 2007, Nucleic acids research.

Involving older people in the design, development, and delivery of an innovative module on aging for undergraduate students

Laura C. Greaves, E. Tullo, L. Wakeling, 2016 .

Quantification of mitochondrial DNA mutation load

Laura C. Greaves, D. Turnbull, K. Khrapko, 2009, Aging cell.

Laura C. Greaves, D. Turnbull, T. Kirkwood, 2014, Mechanisms of Ageing and Development.

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2012, PLoS genetics.

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA−/− mice

Laura C. Greaves, D. Turnbull, D. Deehan, 2016, Scientific Reports.

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2010, Aging cell.

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Laura C. Greaves, D. Turnbull, Holly L. Baines, 2014, Aging cell.

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease

Laura C. Greaves, C. Morris, J. Elson, 2017, Annals of neurology.

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

Laura C. Greaves, O. Govaere, M. Drinnan, 2019, Hepatology.

Differences in the accumulation of mitochondrial defects with age in mice and humans

Laura C. Greaves, D. Turnbull, T. Kirkwood, 2011, Mechanisms of Ageing and Development.

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.

Laura C. Greaves, Robert W. Taylor, D. Turnbull, 2010, Investigative ophthalmology & visual science.

Single-cell multiomic analyses sheds light on mitochondrial mutational selection

Laura C. Greaves, G. Hudson, S. Pickett, 2023, Nature Genetics.

Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk

Laura C. Greaves, D. Turnbull, J. Mathers, 2019, Proceedings of the Nutrition Society.

Age‐associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon

Laura C. Greaves, D. Turnbull, D. Houghton, 2021, Aging cell.

Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer?

Laura C. Greaves, D. Turnbull, J. Mathers, 2009, Proceedings of the National Academy of Sciences.

This Work Is Licensed under a Creative Commons Attribution 3.0 Unported License Date Deposited: the Role of the Mitochondrial Ribosome in Human Disease: Searching for Mutations in 12s Mitochondrial Rrna with High Disruptive Potential

Laura C. Greaves, R. Rodenburg, R. Lightowlers, 2022 .