Sarah A. Scott

发表

Table 2, Ricerca Profiling of ML299

Paul G. Thomas, Eric S. Dawson, Julie L. Engers, 2013 .

Table 3, Eurofins Panlabs Profiling of ML395

Paul G. Thomas, Julie L. Engers, J. Scott Daniels, 2015 .

Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B

Sarah A. Scott, C. Lindsley, H. Brown, 2013, Oncogene.

Design, Synthesis and Biological Evaluation of Halogenated N- (2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8- yl)ethylbenzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 (PLD2) Inhibitor

Sarah A. Scott, S. Jadhav, C. Lindsley, 2011 .

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Sarah A. Scott, Sydney L. Stoops, C. Lindsley, 2009, Bioorganic & medicinal chemistry letters.

Combinatorial modulation of protein prenylation.

Sarah A. Scott, R. Gibbs, C. Fierke, 2007, ACS chemical biology.

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

Craig W Lindsley, Paul G Thomas, Sarah A. Scott, 2013, Journal of medicinal chemistry.

Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.

Sarah A. Scott, Anna L. Blobaum, A. Waterson, 2018, Bioorganic & medicinal chemistry letters.

Multi-organ Abnormalities and mTORC1 Activation in Zebrafish Model of Multiple Acyl-CoA Dehydrogenase Deficiency

Robert P. Carson, Sarah A. Scott, Seok-Hyung Kim, 2013, PLoS genetics.

Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.

Sarah A. Scott, R. Gibbs, J. Reiners, 2007, Journal of medicinal chemistry.

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Sarah A. Scott, R. Gibbs, C. Fierke, 2007, Bioorganic & medicinal chemistry letters.

Context-dependent substrate recognition by protein farnesyltransferase.

Corissa L. Lamphear, James L. Hougland, Richard A Gibbs, 2009, Biochemistry.

Chemical modulation of glycerolipid signaling and metabolic pathways.

Sarah A. Scott, C. Lindsley, H. Brown, 2014, Biochimica et biophysica acta.

Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs.

Sarah A. Scott, R. Gibbs, E. L. Rickert, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

Sarah A. Scott, C. Lindsley, M. Armstrong, 2009, Bioorganic & medicinal chemistry letters.

Phospholipase D Facilitates Efficient Entry of Influenza Virus, Allowing Escape from Innate Immune Inhibition*

Sarah A. Scott, Shalini Sharma, P. Thomas, 2014, The Journal of Biological Chemistry.

Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.

Sarah A. Scott, S. Jadhav, C. Lindsley, 2010, Journal of medicinal chemistry.

Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, Pseudomonas aeruginosa, and NAPE Phospholipase D Enzymes

Sarah A. Scott, Kyle A. Brown, C. Lindsley, 2014, ACS chemical biology.

Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.

Sarah A. Scott, C. Lindsley, H. Brown, 2014, Bioorganic & medicinal chemistry letters.

Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad‐Spectrum Antiviral Activity against Influenza Strains

Sarah A. Scott, P. Thomas, C. Lindsley, 2014, ChemMedChem.

Regulation of Phospholipase D Activity and Phosphatidic Acid Production after Purinergic (P2Y6) Receptor Stimulation*

Sarah A. Scott, C. Lindsley, H. Brown, 2013, The Journal of Biological Chemistry.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Sarah A. Scott, C. Lindsley, H. Brown, 2009, Nature chemical biology.

FAM83B mediates EGFR- and RAS-driven oncogenic transformation.

Sarah A. Scott, Rocky Cipriano, G. Stark, 2012, The Journal of clinical investigation.

Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.

Sarah A. Scott, M. Kumari, R. Zechner, 2012, Cell metabolism.