Paul G Wyatt

发表

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Peter C Ray, Michael Kiczun, Margaret Huggett, 2017, Drug discovery today.

Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

Paul G Wyatt, M. Congreve, H. Jhoti, 2003, Angewandte Chemie.

Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives.

Alison C. Foster, Michael J Allen, Paul G Wyatt, 2002, Bioorganic & medicinal chemistry letters.

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

Ian H Gilbert, Paul G Wyatt, K. Read, 2011, Current topics in medicinal chemistry.

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

Marcel Kaiser, Susan A Charman, Ian H Gilbert, 2013, ChemMedChem.

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.

Michael J Allen, Paul G Wyatt, Mamta Patel, 2002, Bioorganic & medicinal chemistry letters.

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Paul G Wyatt, Valerio Berdini, V. Berdini, 2008, Journal of medicinal chemistry.

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Mladen Vinković, Paul G Wyatt, Jayne Curry, 2009, Journal of medicinal chemistry.

Identification of inhibitors of protein kinase B using fragment-based lead discovery.

Marcel L Verdonk, Paul G Wyatt, Michelle D Garrett, 2007, Journal of medicinal chemistry.

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Ian H Gilbert, Paul G Wyatt, Torsten Luksch, 2011, ChemMedChem.

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Ian Collins, Paul Workman, Edward McDonald, 2006, Bioorganic & medicinal chemistry.

Fragment-based hit identification: thinking in 3D.

Nathan Brown, Steven V Ley, Kristian Birchall, 2013, Drug discovery today.