Gregory Stephanopoulos

发表

Synthetic biology and metabolic engineering.

Gregory Stephanopoulos, G. Stephanopoulos, 2012, ACS synthetic biology.

Metabolic engineering: enabling technology of a bio-based economy

Jie Zhang, Gregory Stephanopoulos, Ann C. Babtie, 2012 .

Letter from AIChE President

Gregory Stephanopoulos, 2016, Bioengineering & translational medicine.

Bioinformatics and Handwriting/Speech Reconition: Uncoventional Applications of Similarity Search Tools

Gregory Stephanopoulos, Kyle Jensen, 2006 .

Modeling of Traffic Flow at Signalized Links

Gregory Stephanopoulos, Panos G Michalopoulos, Vijay B. Pisharody, 1980 .

Metabolic engineering: enabling technology for biofuels production

Mitchell Tai, Gregory Stephanopoulos, G. Stephanopoulos, 2012 .

Metabolic engineering: Perspective of a chemical engineer

Gregory Stephanopoulos, G. Stephanopoulos, 2002 .

Imaging the competition between growth and production of self-assembled lipid droplets at the single-cell level

Andreas E. Vasdekis, Alice Dohnalkova, Gregory Stephanopoulos, 2019, Optical Metrology.

The Web, Biology, and More--A Vision for Chemical Engineering Education (小特集海外における化学工学教育)

Gregory Stephanopoulos, Barry S. Johnston, 2003 .

Machine Learning Approaches to Modeling the Physiochemical Properties of Small Peptides

Mark P. Styczynski, Gregory Stephanopoulos, Kyle Jensen, 2006 .

Metabolic engineering challenges in the post-genomic era

Gregory Stephanopoulos, Hal S. Alper, G. Stephanopoulos, 2004 .

Emerging directions in computer applications to biotechnology: Upgrading the information content of

Gregory Stephanopoulos, G. Stephanopoulos, 1999 .

Downstream reactions and engineering in the microbially reconstituted pathway for Taxol

Ming Jiang, Gregory Stephanopoulos, Blaine A. Pfeifer, 2012, Applied Microbiology and Biotechnology.

Invited comment: Chemical and Biological Engineering

Gregory Stephanopoulos, G. Stephanopoulos, 2003 .

Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line*

Gregory Stephanopoulos, Hyuntae Yoo, Maciek R Antoniewicz, 2008, Journal of Biological Chemistry.

Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets

Gregory Stephanopoulos, Hal Alper, Kohei Miyaoku, 2005, Nature Biotechnology.

Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol

Gregory Stephanopoulos, Haoran Zhang, Marjan De Mey, 2016, Biotechnology and bioengineering.

Efficient utilization of pentoses for bioproduction of the renewable two-carbon compounds ethylene glycol and glycolate.

Gregory Stephanopoulos, Haoran Zhang, Chin Giaw Lim, 2016, Metabolic engineering.

Melanin-Based High-Throughput Screen for l-Tyrosine Production in Escherichia coli

Gregory Stephanopoulos, Christine Nicole S. Santos, G. Stephanopoulos, 2007, Applied and Environmental Microbiology.

Prediction of transcriptional profiles of Synechocystis PCC6803 by dynamic autoregressive modeling of DNA microarray data

Gregory Stephanopoulos, William A. Schmitt, G. Stephanopoulos, 2003, Biotechnology and bioengineering.

Packed bed bioreactor with porous ceramic beads for animal cell culture

Gregory Stephanopoulos, Seujeung Park, G. Stephanopoulos, 1993, Biotechnology and bioengineering.

Effect of spatial inhomogeneities on the coexistence of competing microbial populations

Gregory Stephanopoulos, A. G. Fredrickson, G. Stephanopoulos, 1979 .

A group contribution method for the estimation of equilibrium constants for biochemical reactions

Michael L. Mavrovouniotis, George Stephanopoulos, Gregory Stephanopoulos, 1988 .

Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli

Gregory Stephanopoulos, Christine Nicole S. Santos, Wenhai Xiao, 2012, Proceedings of the National Academy of Sciences.

Enhanced Biosynthesis of Hyaluronic Acid Using Engineered Corynebacterium glutamicum Via Metabolic Pathway Regulation

Huimin Yu, Gregory Stephanopoulos, Zhigang Guo, 2017, Biotechnology journal.

Metabolic Activity Control of the L‐Lysine Fermentation by Restrained Growth Fed‐Batch Strategies

Gregory Stephanopoulos, G. Stephanopoulos, R. Kiss, 1991 .

Engineering promoter regulation

Gregory Stephanopoulos, Curt Fischer, G. Stephanopoulos, 2007, Biotechnology and bioengineering.

Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells.

Jie Zhang, Gregory Stephanopoulos, Christian M. Metallo, 2012, Metabolic engineering.

Carbon Flux Distributions at the Glucose 6‐Phosphate Branch Point in Corynebacterium glutamicum during Lysine Overproduction

Gregory Stephanopoulos, Joseph J. Vallino, G. Stephanopoulos, 1994 .

Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis*

Gregory Stephanopoulos, Yasushi Noguchi, Jamey D. Young, 2009, The Journal of Biological Chemistry.

Metabolomic and 13C‐metabolic flux analysis of a xylose‐consuming Saccharomyces cerevisiae strain expressing xylose isomerase

Gregory Stephanopoulos, Thomas M. Wasylenko, G. Stephanopoulos, 2015, Biotechnology and bioengineering.

Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production

Xixian Chen, Gregory Stephanopoulos, Heng-Phon Too, 2015, Applied Microbiology and Biotechnology.

Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica.

Gregory Stephanopoulos, Haoran Zhang, G. Stephanopoulos, 2015, Metabolic engineering.

Molecular Systems Biology Peer Review Process File Oncogenic K-ras Decouples Glucose and Glutamine Metabolism to Support Cancer Cell Growth Transaction Report

Gregory Stephanopoulos, Lilia Alberghina, Karsten Hiller, 2022 .

Metabolic engineering: Developing new products and processes by constructing functioning biosynthetic pathways in vivo

Gregory Stephanopoulos, Kyle Jensen, Kyle L. Jensen, 2005 .

High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts.

Gregory Stephanopoulos, Jens Nielsen, Mats Akesson, 2005, The Biochemical journal.

Effect of Pyruvate Carboxylase Overexpression on the Physiology of Corynebacterium glutamicum

Gregory Stephanopoulos, Mattheos A. G. Koffas, Gyoo Yeol Jung, 2002, Applied and Environmental Microbiology.

Combinatorial engineering of microbes for optimizing cellular phenotype.

Gregory Stephanopoulos, G. Stephanopoulos, C. N. S. Santos, 2008, Current opinion in chemical biology.

Optimization of amorphadiene synthesis in bacillus subtilis via transcriptional, translational, and media modulation.

Gregory Stephanopoulos, Kang Zhou, Heng-Phon Too, 2013, Biotechnology and bioengineering.

Elucidation of gene interaction networks through time-lagged correlation analysis of transcriptional data.

Gregory Stephanopoulos, William A. Schmitt, G. Stephanopoulos, 2004, Genome research.

Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism

Peng Xu, Gregory Stephanopoulos, Kang Zhou, 2017, Nature Biotechnology.

Metabolic engineering by genome shuffling

Gregory Stephanopoulos, G. Stephanopoulos, 2002, Nature Biotechnology.

Reevaluating synthesis by biology.

Gregory Stephanopoulos, Vikramaditya G. Yadav, Vikramaditya G Yadav, 2010, Current opinion in microbiology.

A high‐throughput screen for hyaluronic acid accumulation in recombinant Escherichia coli transformed by libraries of engineered sigma factors

Huimin Yu, Keith Tyo, Gregory Stephanopoulos, 2008, Biotechnology and bioengineering.

Fragment formula calculator (FFC): determination of chemical formulas for fragment ions in mass spectrometric data.

Gregory Stephanopoulos, Daniel Weindl, Karsten Hiller, 2014, Analytical chemistry.

Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression.

Gregory Stephanopoulos, Gyoo Yeol Jung, Mattheos A G Koffas, 2003, Metabolic Engineering.

CorridendumCorrigendum to “Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis” [Metab. Eng. 13 (2011) 656–665]

Gregory Stephanopoulos, John A. Morgan, Jamey D. Young, 2012 .

A stochastic analysis of the growth of competing microbial populations in a continuous biochemical reactor

Gregory Stephanopoulos, A. G. Fredrickson, R. Aris, 1979 .

The effect of intraparticle convection on nutrient transport in porous biological pellets

Gregory Stephanopoulos, G. Stephanopoulos, K. Tsiveriotis, 1989 .

Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in Escherichia coli.

Gregory Stephanopoulos, Haoran Zhang, G. Stephanopoulos, 2016, Biotechnology journal.

Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate.

Gregory Stephanopoulos, Steven Edgar, Jing-Ke Weng, 2017, ACS synthetic biology.

Metabolic effects on recombinant interferon‐γ glycosylation in continuous culture of Chinese hamster ovary cells

Gregory Stephanopoulos, Gregg B. Nyberg, R. Robert Balcarcel, 1999 .

Method for Designing and Optimizing Random-Search Libraries for Strain Improvement

Gregory Stephanopoulos, Daniel Klein-Marcuschamer, 2010, Applied and Environmental Microbiology.

Application of genome-wide expression analysis to human health and disease.

Mehmet Toner, Gregory Stephanopoulos, Wenzhong Xiao, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid.

Huimin Yu, Gregory Stephanopoulos, G. Stephanopoulos, 2019, Metabolic engineering.

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells.

Gregory Stephanopoulos, Christian M. Metallo, G. Stephanopoulos, 2009, Journal of biotechnology.

Kinetic isotope effects significantly influence intracellular metabolite [superscript 13]C labeling patterns and flux determination

Gregory Stephanopoulos, Thomas M. Wasylenko, G. Stephanopoulos, 2013 .

A Functional Protein Chip for Pathway Optimization and in Vitro Metabolic Engineering

Gregory Stephanopoulos, Gyoo Yeol Jung, G. Stephanopoulos, 2004, Science.

Metabolic requirements for cancer cell proliferation

Gregory Stephanopoulos, Thomas M. Wasylenko, Joanne K. Kelleher, 2016, Cancer & metabolism.

13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells.

Gregory Stephanopoulos, Jie Zhang, G. Stephanopoulos, 2014, Methods in enzymology.

CHAPTER 2 – Review of Cellular Metabolism

Gregory Stephanopoulos, Jens Nielsen, G. Stephanopoulos, 1998 .

Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination.

Gregory Stephanopoulos, Maria I Klapa, G. Stephanopoulos, 2003, BioTechniques.

Linking physiology and transcriptional profiles by quantitative predictive models

George Stephanopoulos, Gregory Stephanopoulos, Jatin Misra, 2007, Biotechnology and bioengineering.

Carbon Flux Distributions at the Pyruvate Branch Point in Corynebacterium glutamicum during Lysine Overproduction

Gregory Stephanopoulos, Joseph J. Vallino, G. Stephanopoulos, 1994 .

A linguistic model for the rational design of antimicrobial peptides

Gregory Stephanopoulos, Kyle Jensen, Kyle L. Jensen, 2006, Nature.

Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene

Xixian Chen, Gregory Stephanopoulos, Kang Zhou, 2013, PloS one.

L-Tyrosine production by deregulated strains of Escherichia coli

Gregory Stephanopoulos, G. Stephanopoulos, T. Lütke-Eversloh, 2007, Applied Microbiology and Biotechnology.

Identifying Functionally Important Mutations from Phenotypically Diverse Sequence Data

Gregory Stephanopoulos, Hal Alper, Kyle Jensen, 2006, Applied and Environmental Microbiology.

Use of Various Measurements for Biomass Estimation

Gregory Stephanopoulos, Arnold L. Demain, G. Stephanopoulos, 1992 .

Characterization of lycopene-overproducing E. coli strains in high cell density fermentations

Gregory Stephanopoulos, Hal Alper, Kohei Miyaoku, 2006, Applied Microbiology and Biotechnology.

Dynamics of gene silencing by RNA interference

Gregory Stephanopoulos, G. Stephanopoulos, R. Raab, 2004, Biotechnology and bioengineering.

Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production

Gregory Stephanopoulos, Nian Liu, G. Stephanopoulos, 2016, Journal of Industrial Microbiology & Biotechnology.

Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis.

Gregory Stephanopoulos, Maciek R Antoniewicz, G. Stephanopoulos, 2007, Analytical chemistry.

Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism

Gregory Stephanopoulos, G. Stephanopoulos, Mark A Keibler, 2012, Biotechnology progress.

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

Ji Luo, Gregory Stephanopoulos, Ralph Weissleder, 2010, Cancer research.

The growth of competing microbial populations in a CSTR with periodically varying inputs

Rutherford Aris, Gregory Stephanopoulos, G. Stephanopoulos, 1979 .

Metabolic engineering.

Keith Tyo, Gregory Stephanopoulos, Keith E. J. Tyo, 1994, Current opinion in biotechnology.

On physiological multiplicity and population heterogeneity of biological systems

Gregory Stephanopoulos, G. Stephanopoulos, John D. Chung, 1996 .

Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway

Gregory Stephanopoulos, Joanne K. Kelleher, Maciek R. Antoniewicz, 2006, Metabolomics.

Induction of mammalian cell death by simple shear and extensional flows

Massimo Morbidelli, Gregory Stephanopoulos, Miroslav Soos, 2009, Biotechnology and bioengineering.

Genome-Wide Dynamic Transcriptional Profiling of the Light-to-Dark Transition in Synechocystis sp. Strain PCC 6803

Gregory Stephanopoulos, Ryan T. Gill, Jatin Misra, 2002, Journal of bacteriology.

Integrated bioprocess for conversion of gaseous substrates to liquids

Gregory Stephanopoulos, Amit Kumar, G. Stephanopoulos, 2016, Proceedings of the National Academy of Sciences.

Response to Hammer et al.: Tuning genetic control--importance of thorough promoter characterization versus generating promoter diversity.

Gregory Stephanopoulos, Hal Alper, Curt R Fischer, 2006, Trends in biotechnology.

Enhancing solubility of deoxyxylulose phosphate pathway enzymes for microbial isoprenoid production

Gregory Stephanopoulos, Kang Zhou, Heng-Phon Too, 2012, Microbial Cell Factories.

Metabolic engineering: enabling technology for biofuels production.

Gregory Stephanopoulos, G. Stephanopoulos, 2008, Metabolic engineering.

Mixed carbon substrates: a necessary nuisance or a missed opportunity?

Gregory Stephanopoulos, Nian Liu, Suvi Santala, 2020, Current opinion in biotechnology.

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Gregory Stephanopoulos, Rameen Beroukhim, Jason W Locasale, 2012, BMC Proceedings.

Exploring biochemical pathways for mono-ethylene glycol (MEG) synthesis from synthesis gas.

Gregory Stephanopoulos, Vassily Hatzimanikatis, Noushin Hadadi, 2017, Metabolic engineering.

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli

Gregory Stephanopoulos, P. K. Ajikumar, Chin Giaw Lim, 2016, Proceedings of the National Academy of Sciences.

Directed evolution of promoters and tandem gene arrays for customizing RNA synthesis rates and regulation.

Gregory Stephanopoulos, Keith E. J. Tyo, Keith E J Tyo, 2011, Methods in enzymology.

Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p

Michael C. Jewett, Gregory Stephanopoulos, Silas G. Villas-Boas, 2009, Proceedings of the National Academy of Sciences.

Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry.

Gregory Stephanopoulos, Maciek R Antoniewicz, G. Stephanopoulos, 2011, Analytical chemistry.

Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry.

Gregory Stephanopoulos, Karsten Hiller, Christian M. Metallo, 2010, Analytical chemistry.

Bioreactor State Estimation

Gregory Stephanopoulos, Seujeung Park, 2001 .

Identification of gene disruptions for increased poly‐3‐hydroxybutyrate accumulation in Synechocystis PCC 6803

Yong-Su Jin, Gregory Stephanopoulos, Keith E. J. Tyo, 2009, Biotechnology progress.

Carboxyl-terminated dendrimer-coated bioactive interface for protein microarray: high-sensitivity detection of antigen in complex biological samples.

Gregory Stephanopoulos, P. K. Ajikumar, Heng-Phon Too, 2007, Langmuir : the ACS journal of surfaces and colloids.

Engineering of Promoter Replacement Cassettes for Fine-Tuning of Gene Expression in Saccharomyces cerevisiae

Gregory Stephanopoulos, Hal Alper, G. Stephanopoulos, 2006, Applied and Environmental Microbiology.

Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene.

Gregory Stephanopoulos, P. K. Ajikumar, Daniel Klein-Marcuschamer, 2007, Trends in biotechnology.

Chemical and Biological Engineering

Gregory Stephanopoulos, 2003 .

Effects of substratum morphology on cell physiology

Gregory Stephanopoulos, Rahul Singhvi, Daniel I. C. Wang, 1994, Biotechnology and bioengineering.

Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model.

Karsten Zengler, Gregory Stephanopoulos, Radhakrishnan Mahadevan, 2015, Integrative biology : quantitative biosciences from nano to macro.

In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production.

Xixian Chen, Gregory Stephanopoulos, Heng-Phon Too, 2017, ACS synthetic biology.

Engineering E. coli–E. coli cocultures for production of muconic acid from glycerol

Gregory Stephanopoulos, Haoran Zhang, G. Stephanopoulos, 2015, Microbial Cell Factories.

Metabolic engineering: a new frontier of chemical reaction engineering

Gregory Stephanopoulos, G. Stephanopoulos, Daniel E. Stafford, 2002 .

Ketogenic Essential Amino Acids Modulate Lipid Synthetic Pathways and Prevent Hepatic Steatosis in Mice

Gregory Stephanopoulos, Yasushi Noguchi, Jamey D. Young, 2010, PloS one.

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method

Gregory Stephanopoulos, Kang Zhou, G. Stephanopoulos, 2013, PloS one.

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Gregory Stephanopoulos, George Poulogiannis, Sarah-Maria Fendt, 2013, Cell.

Identification and Analysis of the Polyhydroxyalkanoate-Specific β-Ketothiolase and Acetoacetyl Coenzyme A Reductase Genes in the Cyanobacterium Synechocystis sp. Strain PCC6803

Gregory Stephanopoulos, G. Stephanopoulos, G. Taroncher-Oldenburg, 2000, Applied and Environmental Microbiology.

Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals

Peng Xu, Gregory Stephanopoulos, G. Stephanopoulos, 2016, Proceedings of the National Academy of Sciences.

The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance

Ji Luo, Gregory Stephanopoulos, Kohjiro Ueki, 2007 .

Optimizing bioconversion pathways through systems analysis and metabolic engineering

Gregory Stephanopoulos, Anthony J Sinskey, G. Stephanopoulos, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Foundations of biochemical engineering : kinetics and thermodynamics in biological systems

Gregory Stephanopoulos, Harvey W. Blanch, E. Terry Papoutsakis, 1983 .

Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

Gregory Stephanopoulos, Maciek R Antoniewicz, G. Stephanopoulos, 2006, Metabolic engineering.

Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae.

Gregory Stephanopoulos, G. Stephanopoulos, G. Fink, 2012, Metabolic engineering.

High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum.

Huimin Yu, Gregory Stephanopoulos, G. Stephanopoulos, 2016, Biotechnology journal.

Modelling and analysis of traffic queue dynamics at signalized intersections

George Stephanopoulos, Panos G Michalopoulos, Gregory Stephanopoulos, 1979 .

Metabolic Flux Analysis

Gregory Stephanopoulos, Maria I. Klapa, G. Stephanopoulos, 2014 .