Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography

Nowadays, nanoparticle probes have received extensive attention largely due to its potential biomedical applications in structural, functional, and molecular imaging. In addition, photoacoustic tomography (PAT), a method based on the photoacoustic effect, is widely recognized as a robust modality to evaluate the structure and function of biological tissues with high optical contrast and high acoustic resolution. The combination of PAT with nanoparticle probes holds promises for detecting and imaging diseased tissues or monitoring their treatments with high sensitivity. This review will introduce the recent advances in the emerging field of nanoparticle probes and their preclinical applications in PAT, as well as relevant perspectives on future development.

[1]  Francisco Sanz-Rodríguez,et al.  Intracellular imaging of HeLa cells by non-functionalized NaYF4 : Er3+, Yb3+ upconverting nanoparticles. , 2010, Nanoscale.

[2]  Andreas Mandelis,et al.  Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics , 2012, Biomedical optics express.

[3]  Vladimir P Zharov,et al.  Quantum dots as multimodal photoacoustic and photothermal contrast agents. , 2008, Nano letters.

[4]  Lei Xi,et al.  Molecular photoacoustic tomography of breast cancer using receptor targeted magnetic iron oxide nanoparticles as contrast agents , 2014, Journal of biophotonics.

[5]  Jun Zhao,et al.  In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[6]  Marco Pedroni,et al.  NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging. , 2011, ACS nano.

[7]  Thomas Schneider,et al.  Ultrabright and bioorthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry. , 2010, Angewandte Chemie.

[8]  Qian Huang,et al.  Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. , 2012, ACS nano.

[9]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[10]  Changqing Li,et al.  A systematic investigation of reflectance diffuse optical tomography using nonlinear reconstruction methods and continuous wave measurements. , 2014, Biomedical optics express.

[11]  Jesse V Jokerst,et al.  Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. , 2012, ACS nano.

[12]  Changfeng Wu,et al.  Swelling-controlled polymer phase and fluorescence properties of polyfluorene nanoparticles. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[13]  Stanislav Emelianov,et al.  Silver nanoplate contrast agents for in vivo molecular photoacoustic imaging. , 2012, ACS nano.

[14]  Stanislav Emelianov,et al.  Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging , 2012, Nature Communications.

[15]  Matthew O'Donnell,et al.  Photoacoustic imaging of early inflammatory response using gold nanorods , 2007 .

[16]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[17]  Hongwei Tang,et al.  Conjugated polymer nanoparticles for drug delivery and imaging. , 2010, ACS applied materials & interfaces.

[18]  Peng Huang,et al.  In vivo volumetric photoacoustic molecular angiography and therapeutic monitoring with targeted plasmonic nanostars. , 2014, Small.

[19]  Younan Xia,et al.  Measuring the Optical Absorption Cross-sections of Au-Ag Nanocages and Au Nanorods by Photoacoustic Imaging. , 2009, The journal of physical chemistry. C, Nanomaterials and interfaces.

[20]  Zhe Wang,et al.  Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. , 2013, Angewandte Chemie.

[21]  Wei Lu,et al.  Copper sulfide nanoparticles for photothermal ablation of tumor cells. , 2010, Nanomedicine.

[22]  Shuming Nie,et al.  Semiconductor nanocrystals: structure, properties, and band gap engineering. , 2010, Accounts of chemical research.

[23]  Da Xing,et al.  In vivo photoacoustic therapy with cancer-targeted indocyanine green-containing nanoparticles. , 2013, Nanomedicine.

[24]  Zhuang Liu,et al.  Carbon nanotubes as photoacoustic molecular imaging agents in living mice. , 2008, Nature nanotechnology.

[25]  Feifan Zhou,et al.  Mitochondria-targeting photoacoustic therapy using single-walled carbon nanotubes. , 2012, Small.

[26]  Stanislav Emelianov,et al.  Indocyanine green-loaded photoacoustic nanodroplets: dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging. , 2014, ACS nano.

[27]  Changfeng Wu,et al.  Conjugated polymer dots for multiphoton fluorescence imaging. , 2007, Journal of the American Chemical Society.

[28]  A. Alivisatos.  Semiconductor Clusters, Nanocrystals, and Quantum Dots , 1996, Science.

[29]  D. Chiu,et al.  Development of ultrabright semiconducting polymer dots for ratiometric pH sensing. , 2011, Analytical chemistry.

[30]  Jesse V. Jokerst,et al.  Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice , 2014, Nature nanotechnology.

[31]  M. Bawendi,et al.  Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites , 1993 .

[32]  Yanhong Luo,et al.  Photoacoustic and photoelectrochemical current spectra of combined CdS/CdSe quantum dots adsorbed on nanostructured TiO2 electrodes, together with photovoltaic characteristics , 2010 .

[33]  Kai Yang,et al.  In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles , 2012, Advanced materials.

[34]  Mingyuan Gao,et al.  Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications , 2009 .

[35]  B. Liu,et al.  Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. , 2013, Small.

[36]  Changfeng Wu,et al.  Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[37]  Jiye Shi,et al.  Nanoscale optical probes for cellular imaging. , 2014, Chemical Society reviews.

[38]  N. Al-Hosiny,et al.  Photoacoustic study of CdS QDs for application in quantum-dot-sensitized solar cells , 2012 .

[39]  R. Stephenson.  A and V , 1962, The British journal of ophthalmology.

[40]  S. Nie,et al.  Luminescent quantum dots for multiplexed biological detection and imaging. , 2002, Current opinion in biotechnology.

[41]  D. Chiu,et al.  Ratiometric temperature sensing with semiconducting polymer dots. , 2011, Journal of the American Chemical Society.

[42]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[43]  Ying Liu,et al.  Applications of Functionalized Fullerenes in Tumor Theranostics , 2012, Theranostics.

[44]  Yuanjin Zheng,et al.  Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles. , 2014, Optics letters.

[45]  Kwangmeyung Kim,et al.  Conjugated polymer nanoparticles for biomedical in vivo imaging. , 2010, Chemical communications.

[46]  Huabei Jiang,et al.  Simultaneous recovery of tissue physiological and acoustic properties and the criteria for wavelength selection in multispectral photoacoustic tomography. , 2009, Optics letters.

[47]  F. Marshall,et al.  In vivo molecular and cellular imaging with quantum dots. , 2005, Current opinion in biotechnology.

[48]  Photoacoustic tomography for imaging nanoparticles. , 2010, Methods in molecular biology.

[49]  Changfeng Wu,et al.  Multicolor conjugated polymer dots for biological fluorescence imaging. , 2008, ACS nano.

[50]  Leon Hirsch,et al.  Nanoshell-Enabled Photonics-Based Imaging and Therapy of Cancer , 2004, Technology in cancer research & treatment.

[51]  Qizhi Zhang,et al.  Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography , 2009, Nanotechnology.

[52]  René M. Botnar,et al.  Magnetic conjugated polymer nanoparticles as bimodal imaging agents. , 2010, Journal of the American Chemical Society.

[53]  Lihong V. Wang,et al.  Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain , 2004 .

[54]  Perry G. Schiro,et al.  Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting. , 2010, Journal of the American Chemical Society.

[55]  Jesse V Jokerst,et al.  Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods. , 2012, ACS nano.

[56]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[57]  P. Hammond,et al.  Fluorescent Multiblock π‐Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting , 2013, Advanced materials.

[58]  Haobin Chen,et al.  Size-dependent property and cell labeling of semiconducting polymer dots. , 2014, ACS applied materials & interfaces.

[59]  James Joseph,et al.  Upconversion Nanoparticles as a Contrast Agent for Photoacoustic Imaging in Live Mice , 2014, Advanced materials.

[60]  Wei Feng,et al.  Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo. , 2012, Journal of the American Chemical Society.

[61]  Shimon Weiss,et al.  Quantum Dots for In Vivo Small-Animal Imaging , 2009, Journal of Nuclear Medicine.

[62]  Xin Cai,et al.  In vivo quantitative evaluation of the transport kinetics of gold nanocages in a lymphatic system by noninvasive photoacoustic tomography. , 2011, ACS nano.

[63]  Stanislav Emelianov,et al.  Quantitative photoacoustic imaging of nanoparticles in cells and tissues. , 2013, ACS nano.

[64]  Stanislav Y Emelianov,et al.  Silica-coated gold nanoplates as stable photoacoustic contrast agents for sentinel lymph node imaging , 2013, Nanotechnology.

[65]  Daxiang Cui,et al.  Synthesis and characterization of bovine serum albumin-conjugated copper sulfide nanocomposites , 2010 .

[66]  Hui Zhang,et al.  Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. , 2005, Nano letters.

[67]  Miss A.O. Penney.  (b) , 1974, The New Yale Book of Quotations.

[68]  Manojit Pramanik,et al.  Molecular photoacoustic imaging of angiogenesis with integrin‐targeted gold nanobeacons , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  Mu-Yi Hua,et al.  Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. , 2013, Biomaterials.

[70]  Shan Jiang,et al.  Multicolor Core/Shell‐Structured Upconversion Fluorescent Nanoparticles , 2008 .

[71]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[72]  Feng-Yan Gao,et al.  Facile preparation of copper sulfide nanoparticles from perovskite templates containing bromide anions , 2009 .

[73]  K. Uvdal,et al.  Multicolor fluorescent semiconducting polymer dots with narrow emissions and high brightness. , 2013, ACS nano.

[74]  Wiendelt Steenbergen,et al.  Evaluation of superparamagnetic iron oxide nanoparticles (Endorem®) as a photoacoustic contrast agent for intra-operative nodal staging. , 2013, Contrast media & molecular imaging.

[75]  C. Brennan,et al.  A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle , 2011, Nature Medicine.

[76]  Dong Liang,et al.  A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. , 2010, Journal of the American Chemical Society.

[77]  Chunlei Zhu,et al.  Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications. , 2013, Chemical Society reviews.

[78]  Zhen Gu,et al.  Conjugated Polymer Fluorescence Probe for Intracellular Imaging of Magnetic Nanoparticles , 2010 .

[79]  V. Zharov,et al.  Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. , 2009, Nature nanotechnology.

[80]  Jonathan R. Lindner,et al.  Microbubbles in medical imaging: current applications and future directions , 2004, Nature Reviews Drug Discovery.

[81]  Zhen Yuan,et al.  Listening to light scattering in turbid media: quantitative optical scattering imaging using photoacoustic measurements with one-wavelength illumination , 2014 .

[82]  Nur Aida Adbul Rahim,et al.  Conjugated Polymer Nanoparticles for Two‐Photon Imaging of Endothelial Cells in a Tissue Model , 2009 .

[83]  J. Olson,et al.  Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting. , 2011, Angewandte Chemie.

[84]  A. Heeger,et al.  Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[85]  Feifan Zhou,et al.  Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor. , 2009, Journal of biomedical optics.

[86]  Wei Lu,et al.  Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. , 2011, Cancer research.

[87]  Hui-Kuo G Shu,et al.  Near complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas , 2004, Cancer.

[88]  Changfeng Wu,et al.  Ratiometric single-nanoparticle oxygen sensors for biological imaging. , 2009, Angewandte Chemie.

[89]  Alaaldin M. Alkilany,et al.  Gold nanoparticles in biology: beyond toxicity to cellular imaging. , 2008, Accounts of chemical research.

[90]  Adam de la Zerda,et al.  Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. , 2010, Nano letters.

[91]  Ji-Xin Cheng,et al.  Controlling the cellular uptake of gold nanorods. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[92]  Daniel T Chiu,et al.  Highly fluorescent semiconducting polymer dots for biology and medicine. , 2013, Angewandte Chemie.

[93]  Wei Lu,et al.  Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. , 2010, Biomaterials.

[94]  Wing-Cheung Law,et al.  Core/shell NaGdF4:Nd(3+)/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications. , 2012, ACS nano.

[95]  D. Chiu,et al.  Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging , 2012, Advanced materials.

[96]  Zhen Cheng,et al.  In vitro and in vivo uncaging and bioluminescence imaging by using photocaged upconversion nanoparticles. , 2012, Angewandte Chemie.

[97]  Michael J Sailor,et al.  Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. , 2009, Cancer research.

[98]  D. Chiu,et al.  A compact and highly fluorescent orange-emitting polymer dot for specific subcellular imaging. , 2012, Chemical communications.

[99]  Huabei Jiang,et al.  Imaging of small nanoparticle-containing objects by finite-element-based photoacoustic tomography. , 2005, Optics letters.

[100]  Michael Weller,et al.  Changing paradigms--an update on the multidisciplinary management of malignant glioma. , 2006, The oncologist.