Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

[1]  Jie Ding,et al.  Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke , 2020, Aging.

[2]  I. Manabe,et al.  Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity , 2020, Frontiers in Cardiovascular Medicine.

[3]  M. Nahrendorf,et al.  Hematopoiesis and Cardiovascular Disease , 2020, Circulation research.

[4]  T. Karantanos,et al.  Inflammation exerts a nonrandom risk in the acquisition and progression of the MPN: Insights from a Mendelian randomization study , 2020, EClinicalMedicine.

[5]  B. Ebert,et al.  Clonal Hematopoiesis as a Model for Premalignant Changes During Aging. , 2019, Experimental hematology.

[6]  T. Hankemeier,et al.  Genome-wide association study of plasma lipids , 2019, bioRxiv.

[7]  B. Brüne,et al.  Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure , 2018, JAMA cardiology.

[8]  A. Tall,et al.  Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2V617F Mice , 2018, Circulation research.

[9]  Aviv Madar,et al.  Abstract 15111: TET2-Driven Clonal Hematopoiesis Predicts Enhanced Response to Canakinumab in the CANTOS Trial: An Exploratory Analysis , 2018 .

[10]  K. Moore,et al.  Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2). , 2018, Journal of the American College of Cardiology.

[11]  Peter J. Campbell,et al.  Population dynamics of normal human blood inferred from somatic mutations , 2018, Nature.

[12]  Paolo Vineis,et al.  Prediction of acute myeloid leukaemia risk in healthy individuals , 2018, Nature.

[13]  B. Ebert,et al.  Predicting progression to AML , 2018, Nature Medicine.

[14]  K. Ballman,et al.  Somatic mutations precede acute myeloid leukemia years before diagnosis , 2018, Nature Medicine.

[15]  D. Hayes,et al.  Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays , 2018, Clinical Cancer Research.

[16]  K. Walsh,et al.  CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease , 2018, Circulation research.

[17]  O. Soehnlein,et al.  The Ins and Outs of Myeloid Cells in Atherosclerosis , 2018, Journal of Innate Immunity.

[18]  S. Mccarroll,et al.  Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms , 2018, Science Translational Medicine.

[19]  P. Libby,et al.  Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion , 2018, Circulation research.

[20]  D. Goukassian,et al.  Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. , 2018, Journal of the American College of Cardiology.

[21]  R. Levine,et al.  Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies. , 2018, Cell stem cell.

[22]  Raquel S. Sevilla,et al.  Exome-wide association study of plasma lipids in >300,000 individuals , 2017, Nature Genetics.

[23]  M. Ladanyi,et al.  Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes. , 2017, Cell stem cell.

[24]  Christopher A. Miller,et al.  Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. , 2017, The Journal of clinical investigation.

[25]  P. Libby,et al.  Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.

[26]  M. Dubé,et al.  DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions. , 2017, Blood.

[27]  Kari Stefansson,et al.  Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. , 2017, Blood.

[28]  Christian Gilissen,et al.  Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life. , 2017, American journal of human genetics.

[29]  S. Gabriel,et al.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease , 2017, The New England journal of medicine.

[30]  Matthew A. Cooper,et al.  Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice , 2017, Science.

[31]  C. Weber,et al.  Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis , 2017, Circulation research.

[32]  C. Balestrieri,et al.  Dnmt3a restrains mast cell inflammatory responses , 2017, Proceedings of the National Academy of Sciences.

[33]  Junlei Chang,et al.  Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states , 2017, Nature Medicine.

[34]  A. LaCasce,et al.  Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[35]  Max Jan,et al.  Clonal hematopoiesis. , 2017, Seminars in hematology.

[36]  B. Ebert,et al.  The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia , 2016, Nature Reviews Cancer.

[37]  Michelle C. Chen,et al.  Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. , 2016, Cancer cell.

[38]  Nicholas Eriksson,et al.  Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms. , 2016, Blood.

[39]  T. Druley,et al.  Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults , 2016, Nature Communications.

[40]  P. Libby,et al.  Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum". , 2016, Journal of the American College of Cardiology.

[41]  Paul M Ridker,et al.  The Present and FutureReview Topic of the WeekA Test in Context: High-Sensitivity C-Reactive Protein , 2016 .

[42]  Francine E. Garrett-Bakelman,et al.  Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells , 2015, Leukemia.

[43]  P. Campbell,et al.  Somatic mutation in cancer and normal cells , 2015, Science.

[44]  Xia Li,et al.  Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 , 2015, Nature.

[45]  B. Ebert,et al.  Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. , 2015, Blood.

[46]  R. Fulton,et al.  Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. , 2015, Cancer cell.

[47]  H. Deeg,et al.  SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition. , 2015, Cancer cell.

[48]  E. Zeggini,et al.  Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis , 2015, Cell reports.

[49]  M. McCarthy,et al.  Age-related clonal hematopoiesis associated with adverse outcomes. , 2014, The New England journal of medicine.

[50]  S. Gabriel,et al.  Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. , 2014, The New England journal of medicine.

[51]  Joshua F. McMichael,et al.  Age-related cancer mutations associated with clonal hematopoietic expansion , 2014, Nature Medicine.

[52]  C. Franceschi,et al.  Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[53]  Bo Sun,et al.  Phosphatase Wip1 Negatively Regulates Neutrophil Migration and Inflammation , 2014, The Journal of Immunology.

[54]  C. Mason,et al.  Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo , 2013, The Journal of experimental medicine.

[55]  Mithat Gonen,et al.  Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis , 2012, Nature Genetics.

[56]  Joshua F. McMichael,et al.  The Origin and Evolution of Mutations in Acute Myeloid Leukemia , 2012, Cell.

[57]  W. Brown.  Framingham Heart Study. , 2011, Journal of clinical lipidology.

[58]  G. Lippi,et al.  Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. , 2009, Archives of pathology & laboratory medicine.

[59]  Michael J. Pencina,et al.  Predicting the 30-Year Risk of Cardiovascular Disease: The Framingham Heart Study , 2009, Circulation.

[60]  M. Pfeffer,et al.  Red blood cell distribution width and mortality risk in a community-based prospective cohort. , 2009, Archives of internal medicine.

[61]  L. Ferrucci,et al.  Red blood cell distribution width and the risk of death in middle-aged and older adults. , 2009, Archives of internal medicine.

[62]  C. Furberg,et al.  Age as a modifiable risk factor for cardiovascular disease , 2008, The Lancet.

[63]  B. Davis,et al.  Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease , 2008, Circulation.

[64]  D. Gilliland,et al.  A role for JAK2 mutations in myeloproliferative diseases. , 2008, Annual review of medicine.

[65]  T. Barbui,et al.  Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera. , 2007, Blood.

[66]  T. Barbui,et al.  Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status. , 2007, Blood.

[67]  D. Levy,et al.  Multiple biomarkers for the prediction of first major cardiovascular events and death. , 2006, The New England journal of medicine.

[68]  W. Takahashi,et al.  [High-sensitivity C-reactive protein]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[69]  G. Pawelec,et al.  The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning , 2006, Mechanisms of Ageing and Development.

[70]  Ralph B D'Agostino,et al.  Prediction of Lifetime Risk for Cardiovascular Disease by Risk Factor Burden at 50 Years of Age , 2006, Circulation.

[71]  T. Barbui,et al.  Vascular and neoplastic risk in a large cohort of patients with polycythemia vera. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[72]  S. Bandinelli,et al.  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC only. TRIALS The , 2004 .

[73]  L. Chan,et al.  Macrophage-Specific p53 Expression Plays a Crucial Role in Atherosclerosis Development and Plaque Remodeling , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[74]  Peter Guttorp,et al.  Evidence that the number of hematopoietic stem cells per animal is conserved in mammals. , 2002, Blood.

[75]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[76]  T. V. van Berkel,et al.  Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE*3-Leiden Transgenic Mice , 2001, Circulation research.

[77]  C. Franceschi,et al.  Inflamm‐aging: An Evolutionary Perspective on Immunosenescence , 2000 .

[78]  F. Luscinskas,et al.  MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions , 1999, Nature.

[79]  A. Green,et al.  Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes , 1997, British journal of haematology.

[80]  D. Gilliland,et al.  Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. , 1996, Blood.

[81]  M. Fey,et al.  Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe. , 1994, Blood.

[82]  P. Nowell.  The clonal evolution of tumor cell populations. , 1976, Science.

[83]  J. Rowley.  A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining , 1973, Nature.

[84]  Nowell Pc,et al.  The minute chromosome (Phl) in chronic granulocytic leukemia. , 1962 .

[85]  P. Armitage,et al.  A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer , 1957, British Journal of Cancer.