Silicon Photonic Biosensors for Lab-on-a-Chip Applications

In the last two decades, we have witnessed a remarkable progress in the development of biosensor devices and their application in areas such as environmental monitoring, biotechnology, medical diagnostics, drug screening, food safety, and security, among others. The technology of optical biosensors has reached a high degree of maturity and several commercial products are on the market. But problems of stability, sensitivity, and size have prevented the general use of optical biosensors for real field applications. Integrated photonic biosensors based on silicon technology could solve such drawbacks, offering early diagnostic tools with better sensitivity, specificity, and reliability, which could improve the effectiveness of in-vivo and in-vitro diagnostics. Our last developments in silicon photonic biosensors will be showed, mainly related to the development of portable and highly sensitive integrated photonic sensing platforms.

[1]  Frank Vollmer,et al.  High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria. , 2007, Optics express.

[2]  Laura M. Lechuga,et al.  Nanomechanical biosensors: a new sensing tool , 2006 .

[3]  J. Sipe,et al.  Optical sensor based on resonant porous silicon structures , 2005, 2005 Quantum Electronics and Laser Science Conference.

[4]  Laura M. Lechuga,et al.  Chapter 5 Optical biosensors , 2005 .

[5]  C. Barrios,et al.  Ultrasensitive Nanomechanical Photonic Sensor Based on Horizontal Slot-Waveguide Resonator , 2006, IEEE Photonics Technology Letters.

[6]  Laura M. Lechuga,et al.  Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices , 2006 .

[7]  A. Llobera,et al.  Design and analysis of silicon antiresonant reflecting optical waveguides for evanescent field sensor , 2000, Journal of Lightwave Technology.

[8]  Dongliang Yin,et al.  Planar single-molecule sensors based on hollow-core ARROW waveguides , 2006, SPIE OPTO.

[9]  Luca De Stefano,et al.  DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips , 2007, Sensors (Basel, Switzerland).

[10]  Laura M. Lechuga,et al.  Microfluidic-optical integrated CMOS compatible devices for label-free biochemical sensing , 2006 .

[11]  K. Zinoviev,et al.  A novel optical waveguide microcantilever sensor for the detection of nanomechanical forces , 2006, Journal of Lightwave Technology.

[12]  P. Sarro,et al.  Microfluidic sensor based on integrated optical hollow waveguides. , 2004, Optics letters.

[13]  B. Lamontagne,et al.  Spiral-path high-sensitivity silicon photonic wire molecular sensor with temperature-independent response. , 2008, Optics letters.

[14]  P. Sarro,et al.  ARROW optical waveguides based sensors , 2004 .

[15]  Wolfgang J. Parak,et al.  Can the light-addressable potentiometric sensor (LAPS) detect extracellular potentials of cardiac myocytes? , 2000, IEEE Transactions on Biomedical Engineering.

[16]  B. Lamontagne,et al.  A Silicon-on-Insulator Photonic Wire Based Evanescent Field Sensor , 2006, IEEE Photonics Technology Letters.

[17]  Trevor M. Benson,et al.  Micro-optical resonators for microlasers and integrated optoelectronics: recent advances and future challenges , 2006, physics/0607239.

[18]  J. W. Parce,et al.  Light-addressable potentiometric sensor for biochemical systems. , 1988, Science.

[19]  Aurel Ymeti,et al.  Development of a multichannel integrated interferometer immunosensor , 2002 .

[20]  R E Kunz,et al.  Novel integrated optical sensor based on a grating coupler triplet. , 1998, Biosensors & bioelectronics.

[21]  L. Lechuga,et al.  An integrated optical interferometric nanodevice based on silicon technology for biosensor applications , 2003 .

[22]  James S. Wilkinson,et al.  Integrated optical Mach-Zehnder biosensor , 1998 .

[23]  M. Koshiba,et al.  Guided modes of nonlinear slot waveguides , 2006, IEEE Photonics Technology Letters.

[24]  S. Boriskina Spectral engineering of bends and branches in microdisk coupled-resonator optical waveguides. , 2007, Optics express.

[25]  Laura M. Lechuga,et al.  Optimized silicon antiresonant reflecting optical waveguides for sensing applications , 2001 .

[26]  Jaume Esteve,et al.  Technological aspects on the fabrication of silicon-based optical accelerometer with ARROW structures , 2004 .

[27]  A. Llobera,et al.  Multimode interference devices based on silicon , 2005, SPIE Optics + Optoelectronics.

[28]  Ye Fang,et al.  Resonant waveguide grating biosensor for living cell sensing. , 2006, Biophysical journal.

[29]  Laura M. Lechuga,et al.  Optical waveguide cantilever actuated by light , 2008 .

[30]  B. Culshaw,et al.  Optical fiber sensor technologies: opportunities and-perhaps-pitfalls , 2004, Journal of Lightwave Technology.