Systemic antibiotics in endodontics-International questionnaire study: Choice of types, dosage, loading and duration.

The aim of the study was to investigate the systematic antibiotics (SAs) prescribing practices in the endodontic practice worldwide. 7500 general practitioners, postgraduate students and endodontists from Israel and the former Soviet Union (FSU) states were invited to fill in an online questionnaire. The first-choice SA was amoxicillin (80.12%) among the Israeli (p < 0.05) and amoxicillin + clavulanic acid (88.92%) among the FSU respondents (p < 0.05). The first-choice SA for patients with penicillin allergy was clindamycin (78.2%) among Israeli and azithromycin (35.96%) among the FSU respondents (p < 0.05). Most of the respondents from Israel as well as from the FSU reported prescribing SA for 5-7 days. Only 6.24% of the former and 2.59% of the latter reported prescribing SA until the symptoms disappeared (p > 0.05). The usage of SAs is often not in accordance with existing international guidelines and differs among different dentist's populations.

[1]  A. Shemesh,et al.  International questionnaire study on systemic antibiotics in endodontics. Part 1. Prescribing practices for endodontic diagnoses and clinical scenarios , 2021, Clinical Oral Investigations.

[2]  F. G. Pappen,et al.  Antibiotic prescription for endodontic infections: a survey of Brazilian Endodontists , 2018, International endodontic journal.

[3]  W. Sabbah,et al.  Antibiotic Use in 2016 by Members of the American Association of Endodontists: Report of a National Survey. , 2017, Journal of endodontics.

[4]  J. Segura-Egea,et al.  Worldwide pattern of antibiotic prescription in endodontic infections. , 2017, International dental journal.

[5]  Jason G. Newland,et al.  Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011. , 2016, JAMA.

[6]  S. Schrag,et al.  US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  S. Oberoi,et al.  Antibiotics in dental practice: how justified are we. , 2015, International dental journal.

[8]  N. Agrawal,et al.  Antibiotic prescription pattern among Indian oral healthcare providers: a cross-sectional survey. , 2014, The Journal of antimicrobial chemotherapy.

[9]  M. Nabavizadeh,et al.  Antibiotic Prescription for Endodontic Treatment: General Dentist Knowledge + Practice in Shiraz , 2011, Iranian endodontic journal.

[10]  W. D’hoore,et al.  Antibiotic prescribing in dental practice in Belgium. , 2009, International endodontic journal.

[11]  J. Azerad,et al.  Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure. , 2009, Journal of medical microbiology.

[12]  R. Bax.  Development of a twice daily dosing regimen of amoxicillin/clavulanate. , 2007, International journal of antimicrobial agents.

[13]  J. Andreasen,et al.  Traumatic intrusion of permanent teeth. Part 3. A clinical study of the effect of treatment variables such as treatment delay, method of repositioning, type of splint, length of splinting and antibiotics on 140 teeth. , 2006, Dental traumatology : official publication of International Association for Dental Traumatology.

[14]  T. Pallasch.  Global antibiotic resistance and its impact on the dental community. , 2000, Journal of the New Jersey Dental Association.

[15]  J. W. Harrison,et al.  The beginning of the end of the antibiotic era? Part I. The problem: abuse of the "miracle drugs". , 1998, Quintessence international.

[16]  T. Macfarlane,et al.  Short-course high-dosage amoxycillin in the treatment of acute dento-alveolar abscess , 1986, British Dental Journal.

[17]  J. Segura-Egea,et al.  European Society of Endodontology position statement: the use of antibiotics in endodontics. , 2018, International endodontic journal.

[18]  Adequate Debridement,et al.  AAE Position Statement: AAE Guidance on the Use of Systemic Antibiotics in Endodontics. , 2017, Journal of endodontics.

[19]  J. Baumgartner,et al.  Antibiotic susceptibility of bacteria associated with endodontic abscesses. , 2003, Journal of endodontics.