Psammaplin A inhibits hepatitis C virus NS3 helicase

[1]  N. Enomoto,et al.  Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia , 2012, Marine drugs.

[2]  S. Tsuneda,et al.  Inhibition of hepatitis C virus NS3 helicase by manoalide. , 2012, Journal of natural products.

[3]  C. Rice.  New insights into HCV replication: potential antiviral targets. , 2011, Topics in antiviral medicine.

[4]  L. Gravitz.  Introduction: A smouldering public-health crisis , 2011, Nature.

[5]  Stefan Zeuzem,et al.  Boceprevir for previously treated chronic HCV genotype 1 infection. , 2011, The New England journal of medicine.

[6]  G. Dusheiko,et al.  Overview of the PROVE studies evaluating the use of telaprevir in chronic hepatitis C genotype 1 patients , 2011, Expert review of anti-infective therapy.

[7]  S. Munir,et al.  Hepatitis C Treatment: current and future perspectives , 2010, Virology Journal.

[8]  Kai Lin.  Development of novel antiviral therapies for hepatitis C virus , 2010, Virologica Sinica.

[9]  C. Cameron,et al.  Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target* , 2010, The Journal of Biological Chemistry.

[10]  S. Lemon,et al.  Development of novel therapies for hepatitis C. , 2010, Antiviral research.

[11]  M. Bouzari,et al.  High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran , 2010, Virology Journal.

[12]  Charles M. Rice,et al.  Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism , 2009, Proceedings of the National Academy of Sciences.

[13]  Ding-Shinn Chen,et al.  Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. , 2009, Journal of medicinal chemistry.

[14]  S. Tsuneda,et al.  High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon. , 2009, Biochemical and biophysical research communications.

[15]  M. Vedadi,et al.  Application of High-Throughput Isothermal Denaturation to Assess Protein Stability and Screen for Ligands , 2008, Journal of biomolecular screening.

[16]  Darius Moradpour,et al.  Replication of hepatitis C virus , 2007, Nature Reviews Microbiology.

[17]  B. Bell,et al.  The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. , 2006, Journal of hepatology.

[18]  D. Nagle,et al.  Bioassay for the Identification of Natural Product-Based Activators of Peroxisome Proliferator-Activated Receptor-γ (PPARγ): The Marine Sponge Metabolite Psammaplin A Activates PPARγ and Induces Apoptosis in Human Breast Tumor Cells , 2006 .

[19]  Mahadev Rao,et al.  Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment* , 2005, Journal of Biological Chemistry.

[20]  Jee H Jung,et al.  Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication , 2004, BMC Cancer.

[21]  T. Simonart,et al.  Iron: a target for the management of Kaposi's sarcoma? , 2004, BMC Cancer.

[22]  R. Bartenschlager,et al.  Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α , 2003 .

[23]  K. Bair,et al.  Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. , 2003, The Journal of organic chemistry.

[24]  Sarah Schalinski,et al.  Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses. , 2003, European journal of biochemistry.

[25]  K. Kristiansen,et al.  The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. , 2002, Developmental cell.

[26]  D. Epps,et al.  Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase. , 2002, Analytical biochemistry.

[27]  C. Bewley,et al.  Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. , 2002, Bioorganic & medicinal chemistry letters.

[28]  B. Synstad,et al.  Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax. , 2002, Bioorganic & medicinal chemistry.

[29]  V. Paul,et al.  New Bromotyrosine Metabolites from the Sponge Aplysinella rhax , 2000 .

[30]  Pentacyclic compounds useful as inhibitors of hepatitis C virus NS3 helicase , 2000 .

[31]  J. Jung,et al.  Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells. , 1999, Anticancer research.

[32]  Jee H Jung,et al.  Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistantStaphylococcus aureus and the DNA gyrase-inhibitory activity , 1999, Archives of pharmacal research.

[33]  J. Jung,et al.  Cytotoxic compounds from a two-sponge association. , 1995, Journal of natural products.

[34]  C. Rice,et al.  Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes , 1993, Journal of virology.

[35]  H. Okayama,et al.  Structure and organization of the hepatitis C virus genome isolated from human carriers , 1991, Journal of virology.

[36]  M. Houghton,et al.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. , 1989, Science.

[37]  F. Schmitz,et al.  Brominated Tyrosine Metabolites from an Unidentified Sponge. , 1988 .

[38]  櫻井 幸,et al.  Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells , 2009 .

[39]  D. Nagle,et al.  Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. , 2006, Journal of natural products.

[40]  H. Kwon,et al.  Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro. , 2004, Cancer letters.

[41]  J. Auwerx,et al.  PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner. , 2003, Oncogene.

[42]  R. De Francesco,et al.  Structure and function of the hepatitis C virus NS3-NS4A serine proteinase. , 2000, Current topics in microbiology and immunology.

[43]  P. Crews,et al.  Phenolic constituents of Psammaplysilla , 1987 .