Training of executive functions in Parkinson's disease

Cognitive disturbances are common in Parkinson's disease (PD). Examination of cognitive function often reveals deficits in executive functions, including maintenance and inhibition of attention, flexibility in thinking, and planning. The involvement of the dopaminergic system in cognitive executive functions has been suggested by numerous studies. The aim of the present study was to analyze the effect of cognitive training on cognitive performance of PD-patients (N=26). Half of the patients participated in a cognitive training regimen, while the other patients only received standard treatment. The outcome showed improved performance of the group with cognitive treatment in two executive tasks after the training period, while no improvement was seen in the standard-treatment group. The results indicate that specific training is required for improvement of executive functions, while general rehabilitation is not sufficient. Thus, PD-patients might benefit from a short-term cognitive executive function training program that is tailored to the individual patient's needs.

[1]  Rebecca Elliott,et al.  Executive functions and their disorders. , 2003, British medical bulletin.

[2]  H. Bokura,et al.  Event-related potentials for response inhibition in Parkinson's disease , 2005, Neuropsychologia.

[3]  I Daum,et al.  Differential executive control impairments in early Parkinson's disease. , 2004, Journal of neural transmission. Supplementum.

[4]  Cognitve estimation: comparison of two tests in nondemented parkinsonian patients , 2003, Neurological Sciences.

[5]  Jean-Claude Baron,et al.  Executive processes in Parkinson's disease: FDG‐PET and network analysis , 2004, Human brain mapping.

[6]  T. Robbins,et al.  Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease , 2005, Neuropsychologia.

[7]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[8]  Tim Shallice,et al.  The Involvement of the Frontal Lobes in Cognitive Estimation , 1978, Cortex.

[9]  J. Giacino,et al.  Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. , 2005, Archives of physical medicine and rehabilitation.

[10]  W. C. Culbertson,et al.  Dimensions of Executive Function in Parkinson’s Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[11]  R. Marié,et al.  Working memory and dopamine: clinical and experimental clues , 2003, Current opinion in neurology.

[12]  L. Defebvre,et al.  Impairment of the supervisory attentional system in early untreated patients with Parkinson’s disease , 1999, Journal of Neurology.

[13]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[14]  B. Schmand,et al.  Cognitive profile of patients with newly diagnosed Parkinson disease , 2005, Neurology.

[15]  Paul W. Burgess,et al.  Behavioural Assessment of the Dysexecutive Syndrome , 1997 .

[16]  Rüdiger Hilker,et al.  Decision-Making Impairments in Patients with Parkinson’s Disease , 2005, Behavioural neurology.

[17]  O. Godefroy,et al.  Frontal syndrome and disorders of executive functions , 2003, Journal of Neurology.