Xenon incorporated in a lipid emulsion inhibits NMDA receptor channels

Background:  Over the past decade hyperpolarized (129)xenon incorporated in lipid emulsions has been studied for the purpose of imaging enhancement in radiology. Xenon (Xe), a NMDA (N‐methyl‐D‐aspartate)‐receptor antagonist, has neuroprotective properties even at subanesthetic concentrations. Thus, its intravenous administration for this purpose deserves further evaluation. In this study, we investigated in an in vitro model the effect of Xe, incorporated in a lipid emulsion (Lipofundin MCT® 20%), on the NMDA receptor channel of cortical neurons of the mouse.

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