De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

[1]  J. Slack,et al.  Reprogramming of Various Cell Types to a Beta-Like State by Pdx1, Ngn3 and MafA , 2013, PLoS ONE.

[2]  J. O'neil,et al.  Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo , 2013, Stem cells.

[3]  K. Hochedlinger,et al.  Chromatin dynamics during cellular reprogramming , 2013, Nature.

[4]  M. Sander,et al.  Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. , 2013, Cell reports.

[5]  J. Schug,et al.  Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. , 2013, Stem cell research.

[6]  Rudolf Jaenisch,et al.  Mechanisms and models of somatic cell reprogramming , 2013, Nature Reviews Genetics.

[7]  R. Wells,et al.  Robust cellular reprogramming occurs spontaneously during liver regeneration. , 2013, Genes & development.

[8]  K. Kaestner,et al.  Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity , 2013, PLoS genetics.

[9]  W. Wong,et al.  Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming , 2012, Cell.

[10]  M. Weiss,et al.  Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. , 2012, Cell stem cell.

[11]  R. DePinho,et al.  Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation , 2012, Nature Genetics.

[12]  J. Slack,et al.  Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA , 2011, The Biochemical journal.

[13]  Rudolf Jaenisch,et al.  Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. , 2011, Cell stem cell.

[14]  J. Wells,et al.  Generating human intestinal tissue from pluripotent stem cells in vitro , 2011, Nature Protocols.

[15]  Hans Clevers,et al.  Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. , 2011, Gastroenterology.

[16]  Jason I. Herschkowitz,et al.  The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo , 2011, Proceedings of the National Academy of Sciences.

[17]  Elizabeth E. Hoskins,et al.  Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro , 2010, Nature.

[18]  V. Vedantham,et al.  Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors , 2010, Cell.

[19]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[20]  P. Serup,et al.  Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function , 2009, Proceedings of the National Academy of Sciences.

[21]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[22]  L. Chan,et al.  Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. , 2009, Developmental cell.

[23]  N. Chao.  Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .

[24]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[25]  A. Bang,et al.  Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.

[26]  H. Deng,et al.  In vitro derivation of functional insulin-producing cells from human embryonic stem cells , 2007, Cell Research.

[27]  Friedrich Beermann,et al.  Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. , 2007, Developmental cell.

[28]  M. Kay,et al.  Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

[29]  E. Kroon,et al.  Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.

[30]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[31]  Rudolf Jaenisch,et al.  Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues , 2005, Cell.

[32]  H. Kaneto,et al.  A Crucial Role of MafA as a Novel Therapeutic Target for Diabetes*♦ , 2005, Journal of Biological Chemistry.

[33]  Daniel Metzger,et al.  Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium , 2004, Genesis.

[34]  Susan E. Schonhoff,et al.  Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. , 2004, Developmental biology.

[35]  Smaroula Dilioglou,et al.  Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide–based retroviral vector , 2004, Nature Biotechnology.

[36]  T. Graf,et al.  Stepwise Reprogramming of B Cells into Macrophages , 2004, Cell.

[37]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[38]  Isabelle Duluc,et al.  Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium , 2002, The EMBO journal.

[39]  D. Gumucio,et al.  cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine* , 2002, The Journal of Biological Chemistry.

[40]  M. Noda,et al.  [Mechanism of glucose-induced insulin secretion]. , 2002, Nihon rinsho. Japanese journal of clinical medicine.

[41]  D. Melton,et al.  Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. , 2002, Development.

[42]  G. Korbutt,et al.  Glucose-dependent insulin release from genetically engineered K cells. , 2000, Science.

[43]  I. Barshack,et al.  Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia , 2000, Nature Medicine.

[44]  Daniel Pinto,et al.  Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines* , 1999, The Journal of Biological Chemistry.

[45]  B. Spiegelman,et al.  Initiation of myoblast to brown fat switch by a PRDM 16 – C / EBP-b transcriptional complex , 2009 .

[46]  Ames,et al.  Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen , 2000 .