Transient Paraplegia due to Accidental Intrathecal Bupivacaine Infiltration Following Pre-Emptive Analgesia in a Patient With Missed Sacral Dural Ectasia

Study Design. A case report with review of the literature. Objective. To highlight the need for careful magnetic resonance imaging evaluation for the presence of incidental lumbosacral dural anomalies before attempting caudal epidural interventions. Summary of Background Data. Pre-emptive analgesia through the caudal epidural route provides good postoperative pain relief in spine surgeries. Several precautions have been advised in the literature. Presence of sacral-dural ectasia should be considered a relative contraindication for this procedure. Methods. A 50-year old woman underwent posterior instrumented spinal fusion for L4–L5 spondylolisthesis under general anesthesia. She received single shot caudal epidural analgesia at the start of the procedure. Results. After complete emergence from anesthesia, she had complete motor and sensory loss below the T12 spinal level, which reversed to normal neurology in 6 hours. Retrospective evaluation of the patient's magnetic resonance imaging showed an ectatic, low lying lumbosacral dural sac which had been overlooked in the initial evaluation. The drugs given by the caudal route have been accidentally administered into the thecal sac causing a brief period of neurologic deficit. Conclusion. This unexpected complication has been reported only in the pediatric literature before. It is important to look for the presence of lumbosacral dural anomalies before planning caudal epidural injections in adults also. Sacral dural ectasia and other lumbosacral anomalies must be recognized as contraindications for caudal epidural pre-emptive analgesia for spine surgery. Other modes of postoperative pain relief should be tried in these patients.

[1]  Howard S. Smith,et al.  Preliminary results of a randomized, equivalence trial of fluoroscopic caudal epidural injections in managing chronic low back pain: Part 1--Discogenic pain without disc herniation or radiculitis. , 2008, Pain physician.

[2]  I. Cohen Caudal block complication in a patient with trisomy 13 , 2006, Paediatric anaesthesia.

[3]  N. Şenoğlu,et al.  Landmarks of the sacral hiatus for caudal epidural block: an anatomical study. , 2005, British journal of anaesthesia.

[4]  H. Muir,et al.  Dural ectasia: a likely cause of inadequate spinal anaesthesia in two parturients with Marfan's syndrome. , 2005, British journal of anaesthesia.

[5]  S. Rajasekaran,et al.  Preemptive analgesia for postoperative pain relief in lumbosacral spine surgeries: a randomized controlled trial. , 2004, The spine journal : official journal of the North American Spine Society.

[6]  K. Berge,et al.  New-onset neurologic deficits after general anesthesia for MRI. , 2002, Mayo Clinic proceedings.

[7]  Blake A. Johnson,et al.  Epidurography and therapeutic epidural injections: technical considerations and experience with 5334 cases. , 1999, AJNR. American journal of neuroradiology.

[8]  P. Steen,et al.  Paraplegia after thoracotomy – not caused by the epidural catheter , 1999, Acta anaesthesiologica Scandinavica.

[9]  G. Afshan,et al.  Total spinal anaesthesia following caudal block with bupivacaine and buprenorphine , 1996, Paediatric anaesthesia.

[10]  C. Dickman,et al.  Surgical management of spinal epidural hematoma: relationship between surgical timing and neurological outcome. , 1995, Journal of neurosurgery.

[11]  M. Chong,et al.  Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization , 1993, Anesthesia and analgesia.

[12]  J. Desparmet Total spinal anesthesia after caudal anesthesia in an infant. , 1990, Anesthesia and analgesia.

[13]  E. Fishman,et al.  Dural ectasia is a common feature of the Marfan syndrome. , 1988, American journal of human genetics.

[14]  D. Lint,et al.  Cauda equina syndrome as a complication of free epidural fat-grafting. A report of two cases and a review of the literature. , 1988, The Journal of bone and joint surgery. American volume.

[15]  E. Fishman,et al.  Sacral Abnormalities in Marfan Syndrome , 1983, Journal of computer assisted tomography.

[16]  J. Edeiken,et al.  Vertebral scalloping in neurofibromatosis. , 1970, Radiology.