Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.
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Y. Marcel | I. Tabas | M. Ouimet | V. Franklin | E. Mak | Xianghai Liao
[1] I. Tanida. Autophagosome formation and molecular mechanism of autophagy. , 2011, Antioxidants & redox signaling.
[2] Xiaohui Xie,et al. Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy. , 2011, Cell metabolism.
[3] S. Milstien,et al. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy , 2011, Cell Death and Differentiation.
[4] B. Asztalos,et al. Importance of macrophage cholesterol content on the flux of cholesterol mass , 2010, Journal of Lipid Research.
[5] T. Yoshimori,et al. The origin of the autophagosomal membrane , 2010, Nature Cell Biology.
[6] A. Cuervo,et al. Autophagy and lipids: tightening the knot , 2010, Seminars in Immunopathology.
[7] A. Cuervo,et al. Altered lipid content inhibits autophagic vesicular fusion , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[8] O. Wiest,et al. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. , 2010, Journal of medicinal chemistry.
[9] K. Moore,et al. MiR-33 Contributes to the Regulation of Cholesterol Homeostasis , 2010, Science.
[10] M. Phillips,et al. High-density lipoprotein heterogeneity and function in reverse cholesterol transport , 2010, Current opinion in lipidology.
[11] A. Khera,et al. Future Therapeutic Directions in Reverse Cholesterol Transport , 2010, Current atherosclerosis reports.
[12] F. Maxfield,et al. Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. , 2009, Biochimica et biophysica acta.
[13] Robert V Farese,et al. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T , 2009, Cell.
[14] M. Komatsu,et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis , 2009, Proceedings of the National Academy of Sciences.
[15] Shengkan Jin,et al. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice , 2009, Autophagy.
[16] M. Czaja,et al. Autophagy regulates adipose mass and differentiation in mice. , 2009, The Journal of clinical investigation.
[17] L. Jia,et al. Everolimus, a promising medical therapy for coronary heart disease? , 2009, Medical hypotheses.
[18] G. Schmitz,et al. Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages. , 2009, Biochimica et biophysica acta.
[19] R. Parton,et al. Lipid droplet-organelle interactions; sharing the fats. , 2009, Biochimica et biophysica acta.
[20] Z. Elazar,et al. Lipophagy: selective catabolism designed for lipids. , 2009, Developmental cell.
[21] Keiji Tanaka,et al. The MAP1-LC3 conjugation system is involved in lipid droplet formation. , 2009, Biochemical and biophysical research communications.
[22] M. Czaja,et al. Autophagy regulates lipid metabolism , 2009, Nature.
[23] Hye-Won Shin,et al. Retroendocytosis pathway of ABCA1/apoA‐I contributes to HDL formation , 2009, Genes to cells : devoted to molecular & cellular mechanisms.
[24] B. Chang,et al. Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis , 2008, Circulation research.
[25] D. Teupser,et al. Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia. , 2008, Atherosclerosis.
[26] Y. Marcel,et al. In Vivo Reverse Cholesterol Transport From Macrophages Lacking ABCA1 Expression Is Impaired , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[27] Deborah A. Brown,et al. Fluorescent Detection of Lipid Droplets and Associated Proteins , 2007, Current protocols in cell biology.
[28] Jody C. Ullery,et al. Effects of cellular cholesterol loading on macrophage foam cell lysosome acidifications⃞ Published, JLR Papers in Press, February 16, 2007. , 2007, Journal of Lipid Research.
[29] R. Lehner,et al. Attenuation of Adipocyte Triacylglycerol Hydrolase Activity Decreases Basal Fatty Acid Efflux* , 2007, Journal of Biological Chemistry.
[30] Edward N Baker,et al. High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon. , 2007, Biochemistry.
[31] Y. Ohsaki,et al. Cholesterol depletion induces autophagy. , 2006, Biochemical and biophysical research communications.
[32] W. Jerome,et al. Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder. , 2006, Rejuvenation research.
[33] Peter Tontonoz,et al. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. , 2006, Annual review of medicine.
[34] Jody C. Ullery,et al. Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500059-JLR200 , 2005, Journal of Lipid Research.
[35] R. Pakala,et al. Rapamycin Attenuates Atherosclerotic Plaque Progression in Apolipoprotein E Knockout Mice: Inhibitory Effect on Monocyte Chemotaxis , 2005, Journal of cardiovascular pharmacology.
[36] K. Ley,et al. Macrophage differentiation to foam cells. , 2005, Current pharmaceutical design.
[37] T. Ueno,et al. Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy , 2005, Autophagy.
[38] D. Klionsky. The molecular machinery of autophagy: unanswered questions , 2005, Journal of Cell Science.
[39] M. Linton,et al. ACAT1 Deficiency Disrupts Cholesterol Efflux and Alters Cellular Morphology in Macrophages , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[40] P. Nambi,et al. Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice. , 2003, Transplantation proceedings.
[41] M. Reilly,et al. Overexpression of Apolipoprotein A-I Promotes Reverse Transport of Cholesterol From Macrophages to Feces In Vivo , 2003, Circulation.
[42] Takeshi Tokuhisa,et al. Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells , 2001, The Journal of cell biology.
[43] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[44] A. Tall,et al. Specific Binding of ApoA-I, Enhanced Cholesterol Efflux, and Altered Plasma Membrane Morphology in Cells Expressing ABC1* , 2000, The Journal of Biological Chemistry.
[45] Y. Higashi,et al. Lysosomal accumulation of oxidized phosphatidylcholine-apolipoprotein B complex in macrophages: intracellular fate of oxidized low density lipoprotein. , 2000, Biochimica et biophysica acta.
[46] W. Jerome,et al. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. , 1999, Journal of lipid research.
[47] P. Yancey,et al. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network. , 1998, Journal of lipid research.
[48] P. Yancey,et al. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. , 1998, Journal of lipid research.
[49] A. Cuervo,et al. A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins* , 1997, The Journal of Biological Chemistry.
[50] W D Wagner,et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. , 1994, Circulation.
[51] M. Brown,et al. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. , 1980, The Journal of biological chemistry.
[52] Richard G. W. Anderson,et al. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins , 1979, The Journal of cell biology.
[53] M. Brown,et al. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[54] A. Beaudet,et al. Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. , 1975, The Journal of biological chemistry.
[55] A. Rudich,et al. Potential role of autophagy in modulation of lipid metabolism. , 2010, American journal of physiology. Endocrinology and metabolism.
[56] Shobha Ghosh,et al. Macrophage cholesteryl ester mobilization and atherosclerosis. , 2010, Vascular pharmacology.
[57] M. Brown,et al. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. , 1979, Proceedings of the National Academy of Sciences of the United States of America.