Susceptibility of Anaerobes to Cefoxitin and Other Cephalosporins

The in vitro susceptibility of 155 strains of anaerobic bacteria to five cephalosporin antibiotics was tested. Cefoxitin was the most active against 33 isolates of Bacteroides fragilis; 82% of the strains were sensitive at 16 μg/ml. At 64 μg/ml cefazolin and cephaloridine were also generally effective. Cephalothin and cephalexin were relatively inactive versus B. fragilis. Cefoxitin, cephaloridine, cefazolin, and cephalothin showed comparable activity against 122 strains of anaerobes other than B. fragilis. More than 90% of the strains were sensitive to each of these antimicrobials at 16 μg/ml. Cephalexin was the least effective cephalosporin against all species tested.

[1]  H. Onishi,et al.  Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Resistance to Beta-Lactamase Inactivation , 1974, Antimicrobial Agents and Chemotherapy.

[2]  J. Pauls,et al.  Comparative Serum Levels and Urinary Recovery of Cefazolin, Cephaloridine, and Cephalothin in Man , 1974, Journal of clinical pharmacology.

[3]  D. Hendlin,et al.  Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Susceptibility Studies , 1974, Antimicrobial Agents and Chemotherapy.

[4]  J. Kosmidis,et al.  Cefoxitin, a New Semi-synthetic Cephamycin: An In-vitro and In-vivo Comparison with Cephalothin , 1973, British medical journal.

[5]  S. Gorbach,et al.  Abdominal trauma, anaerobes, and antibiotics. , 1973, Surgery, gynecology & obstetrics.

[6]  J. W. Kislak.  The susceptibility of Bacteroides fragilis to 24 antibiotics. , 1973, The Journal of infectious diseases.

[7]  W. Farrar,et al.  Cephalosporinase Activity in Bacteroides fragilis , 1973, Antimicrobial Agents and Chemotherapy.

[8]  H. Onishi,et al.  Cephamycins, a New Family of β-Lactam Antibiotics: Antibacterial Activity and Resistance to β-Lactamase Degradation , 1973, Antimicrobial Agents and Chemotherapy.

[9]  W. J. Martin,et al.  In Vitro Antimicrobial Susceptibility of Anaerobic Bacteria Isolated from Clinical Specimens , 1972, Antimicrobial Agents and Chemotherapy.

[10]  E. Steers,et al.  An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. , 1959, Antibiotics & chemotherapy.

[11]  J. Sherris,et al.  Antibiotic sensitivity testing. Report of an international collaborative study. , 1971, Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology.

[12]  H. Black,et al.  Blood, urine and tissue concentrations of the cephalosporin antibiotics in normal subjects. , 1971, Postgraduate medical journal.

[13]  J. Henry,et al.  Anaerobic infections. , 1969, Postgraduate medicine.