A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

[1]  Gennifer E. Merrihew,et al.  Mitochondrial Dysfunction in NnaD Mutant Flies and Purkinje Cell Degeneration Mice Reveals a Role for Nna Proteins in Neuronal Bioenergetics , 2010, Neuron.

[2]  D. Gerlich,et al.  Tubulin polyglutamylation stimulates spastin-mediated microtubule severing , 2010, The Journal of cell biology.

[3]  Y. Kimura,et al.  Identification of Tubulin Deglutamylase among Caenorhabditis elegans and Mammalian Cytosolic Carboxypeptidases (CCPs)*♦ , 2010, The Journal of Biological Chemistry.

[4]  J. Sironi,et al.  CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  Mitsutoshi Setou,et al.  Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry , 2010, Proceedings of the National Academy of Sciences.

[6]  W. Sale,et al.  Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity , 2010, Current Biology.

[7]  M. Hirono,et al.  Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins , 2010, Current Biology.

[8]  J. Gaertig,et al.  Hyperglutamylation of Tubulin Can either Stabilize or Destabilize Microtubules in the Same Cell , 2009, Eukaryotic Cell.

[9]  A. Spada,et al.  The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) mice , 2008, Vision Research.

[10]  A. van Dorsselaer,et al.  Polyglutamylation Is a Post-translational Modification with a Broad Range of Substrates* , 2008, Journal of Biological Chemistry.

[11]  I. Drummond,et al.  The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. , 2007, Molecular biology of the cell.

[12]  Sean L Seymour,et al.  The Paragon Algorithm, a Next Generation Search Engine That Uses Sequence Temperature Values and Feature Probabilities to Identify Peptides from Tandem Mass Spectra*S , 2007, Molecular & Cellular Proteomics.

[13]  C. Janke,et al.  A targeted multienzyme mechanism for selective microtubule polyglutamylation. , 2007, Molecular cell.

[14]  J. Morgan,et al.  The Purkinje cell degeneration (pcd) mouse: An unexpected molecular link between neuronal degeneration and regeneration , 2007, Brain Research.

[15]  F. Avilés,et al.  A novel subfamily of mouse cytosolic carboxypeptidases , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  F. Avilés,et al.  Nnal‐like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  M. Mann,et al.  In-gel digestion for mass spectrometric characterization of proteins and proteomes , 2006, Nature Protocols.

[18]  P. Gallagher,et al.  Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues. , 2006, American journal of physiology. Cell physiology.

[19]  James I. Morgan,et al.  The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype , 2006, Molecular and Cellular Neuroscience.

[20]  Andrey V Kajava,et al.  Tubulin Polyglutamylase Enzymes Are Members of the TTL Domain Protein Family , 2005, Science.

[21]  W. Denk,et al.  Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J. Rossier,et al.  Posttranslational modification of brain tubulins from the Antarctic fish Notothenia coriiceps: reduced C-terminal glutamylation correlates with efficient microtubule assembly at low temperature. , 2004, Biochemistry.

[23]  Rodrigo Lopez,et al.  Multiple sequence alignment with the Clustal series of programs , 2003, Nucleic Acids Res..

[24]  L. Martin,et al.  Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death. , 2002, Journal of neurobiology.

[25]  R. Sidman,et al.  Purkinje cell degeneration (pcd) Phenotypes Caused by Mutations in the Axotomy-Induced Gene, Nna1 , 2002, Science.

[26]  K. Kohama,et al.  Myosin Light Chain Kinase as a Multifunctional Regulatory Protein of Smooth Muscle Contraction , 2001, IUBMB life.

[27]  C. Regnard,et al.  Polyglutamylation of Nucleosome Assembly Proteins* , 2000, The Journal of Biological Chemistry.

[28]  P. Denoulet,et al.  Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells. , 1999, Journal of cell science.

[29]  R. Bigsby,et al.  A 310-bp minimal promoter mediates smooth muscle cell-specific expression of telokin. , 1998, American journal of physiology. Cell physiology.

[30]  J. Rossier,et al.  Characterization of the chicken telokin heterogeneity by time-of-flight mass spectrometry. , 1997, Biochemistry.

[31]  T. Miller,et al.  Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells , 1996, The Journal of Neuroscience.

[32]  B. Safiejko-Mroczka,et al.  Improved methods for preserving macromolecular structures and visualizing them by fluorescence and scanning electron microscopy. , 1995, Scanning microscopy.

[33]  H. Mazarguil,et al.  Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. , 1994, Journal of cell science.

[34]  B. Eddé,et al.  Reversible polyglutamylation of alpha- and beta-tubulin and microtubule dynamics in mouse brain neurons. , 1993, Molecular biology of the cell.

[35]  U. Plessmann,et al.  Characterization of the tubulin-tyrosine ligase , 1993, The Journal of cell biology.

[36]  B. Eddé,et al.  Distribution of glutamylated alpha and beta-tubulin in mouse tissues using a specific monoclonal antibody, GT335. , 1992, European journal of cell biology.

[37]  J. Wehland,et al.  Class II tubulin, the major brain β tubulin isotype is polyglutamylated on glutamic acid residue 435 , 1992, FEBS letters.

[38]  J. L. Le Caer,et al.  Characterization of a major brain tubulin variant which cannot be tyrosinated. , 1991, Biochemistry.

[39]  J. Rossier,et al.  Posttranslational glutamylation of alpha-tubulin. , 1990, Science.

[40]  F. Gros,et al.  Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines. , 1987, Developmental biology.

[41]  G. Gundersen,et al.  Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules , 1987, The Journal of cell biology.

[42]  T. L. Coombs,et al.  The mechanism of inhibition of carboxypeptidase A by 1,10-phenanthroline. , 1962, Biochemistry.

[43]  M. Bornens,et al.  Glutamylation of centriole and cytoplasmic tubulin in proliferating non-neuronal cells. , 1998, Cell motility and the cytoskeleton.

[44]  M. Bré,et al.  Glutamylated tubulin probed in ciliates with the monoclonal antibody GT335. , 1994, Cell motility and the cytoskeleton.

[45]  R. Vallee.  Reversible assembly purification of microtubules without assembly-promoting agents and further purification of tubulin, microtubule-associated proteins, and MAP fragments. , 1986, Methods in enzymology.

[46]  R. J. Mullen,et al.  Purkinje cell degeneration, a new neurological mutation in the mouse. , 1976, Proceedings of the National Academy of Sciences of the United States of America.