Molecular diversity and functions of glutamate receptors.

RECEPTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320 MULTIPLICITY OF GLUTAMATE RECEPTORS .. . .. . .. . . . .... . .. . .. . . . 321 Gene Family . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321 Alternative Splicing . . . ... . .. . . ... . . ... .. ... . .. .. . . . ... . . . . . . . . . .. .. . . 327 RNA Editing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330 Heteromeric Formation . . . . . . . .. .. . . , ,. 331 Expression Pattern . . . . .. . .. . . . .. ... . . . . . . . . .. . . . .. . .. . .. .. . . . .. . . . . . . 332 STRUCTURES OF GLUTAMATE RECEPTORS . . . . . . . . . . . . . . . . . . . . . . . . . . 333 Transmembrane Topology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333 Glutamate-Binding Domain ... . . .. . . . . .. .. . . . . . . . . . .. . .. . .. . . . ..... ... 334 Channel Pore . . . . .. . .. . .. ... . . . . . . . . .. . . . . . . .. . ... . . .. .. . .. . .. .... . .. 336 Phosphorylation Site . . . . . . .. . .. . . . . .. .. . .. .. . .. . .. . . . .. . .. .. . ... .. . . . 337 Other Possible Regulatory Sites . .. . . . .. . . . . . . .. ... . . .. . . . . .. ... ... . .. . 338 IMPLICATIONS OF GLUTAMATE RECEPTOR DIVERSITY AND FUTURE PROSPECTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338

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