Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.
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Manuel Benito | M. Benito | A. Porras | I. Fabregat | S. Zuluaga | A. Valladares | A. Álvarez | Isabel Fabregat | Blanca Herrera | B. Herrera | Almudena Porras | Susana Zuluaga | Amparo Valladares | Alberto M Alvarez
[1] E. Nisoli,et al. Tumor necrosis factor-α induces apoptosis in rat brown adipocytes , 1997, Cell Death and Differentiation.
[2] N. Maulik,et al. Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis. , 1998, Free radical biology & medicine.
[3] S. Cory,et al. The Bcl2 family: regulators of the cellular life-or-death switch , 2002, Nature Reviews Cancer.
[4] J. Engelman,et al. Constitutively Active Mitogen-activated Protein Kinase Kinase 6 (MKK6) or Salicylate Induces Spontaneous 3T3-L1 Adipogenesis* , 1999, The Journal of Biological Chemistry.
[5] P. Trayhurn,et al. A commentary on the interpretation of in vitro biochemical measures of brown adipose tissue thermogenesis. , 1989, Canadian journal of physiology and pharmacology.
[6] H. Krieger-Brauer,et al. Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2* , 1997, The Journal of Biological Chemistry.
[7] S. R. Datta,et al. DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein , 2002, Science.
[8] B. Lowell,et al. Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat , 1995, Diabetes.
[9] B. Lowell,et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue , 1993, Nature.
[10] Roy J Martin,et al. TNFα Induces and Insulin Inhibits Caspase 3-Dependent Adipocyte Apoptosis , 2001 .
[11] T. Gettys,et al. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. , 1994, Molecular endocrinology.
[12] G. Romano,et al. Insulin and IGF-I Receptors Signaling in Protection from Apoptosis , 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[13] M. Benito,et al. Noradrenaline induces brown adipocytes cell growth via β‐receptors by a mechanism dependent on ERKs but independent of cAMP and PKA , 2000, Journal of cellular physiology.
[14] E. Nisoli,et al. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[15] B. Mignotte,et al. Mitochondrial reactive oxygen species in cell death signaling. , 2002, Biochimie.
[16] B. Cannon,et al. Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. , 1990, The Journal of biological chemistry.
[17] J. Houštěk,et al. Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors. , 1992, The Journal of biological chemistry.
[18] S. Farmer. The forkhead transcription factor Foxo1: a possible link between obesity and insulin resistance. , 2003, Molecular cell.
[19] B. Thorens,et al. cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells. , 2002, Diabetes.
[20] M. Benito,et al. Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes. , 1997, Molecular endocrinology.
[21] G. Tomasevic,et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma , 2003, Nature Medicine.
[22] M. Benito,et al. IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes , 1993, The Journal of cell biology.
[23] Emad S. Alnemri,et al. Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner , 1999, The Journal of cell biology.
[24] V. Mootha,et al. Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice* , 2000, The Journal of Biological Chemistry.
[25] S. Thorgeirsson,et al. Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells. , 1998, Biochemical and biophysical research communications.
[26] Y. Risler,et al. TNF-α activates at least two apoptotic signaling cascades , 1998, Oncogene.
[27] R. Rhoads. Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis* , 1999, The Journal of Biological Chemistry.
[28] R. von Harsdorf,et al. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c‐independent apoptosis blocked by Bcl‐2 , 1999, The EMBO journal.
[29] B. Miroux,et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production , 2000, Nature Genetics.
[30] M. Peter,et al. Inactivation of Caspase-8 on Mitochondria of Bcl-xL-expressing MCF7-Fas Cells , 2002, The Journal of Biological Chemistry.
[31] M. Benito,et al. TNF‐α induces apoptosis in rat fetal brown adipocytes in primary culture , 1997 .
[32] M. Benito,et al. p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes. , 1998, Molecular endocrinology.
[33] J. Venter,et al. An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. , 1991, The Journal of biological chemistry.
[34] J. Himms-Hagen,et al. A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. , 1978, Biochemical and biophysical research communications.
[35] M. Kitamura,et al. Selective Involvement of Superoxide Anion, but Not Downstream Compounds Hydrogen Peroxide and Peroxynitrite, in Tumor Necrosis Factor-α-induced Apoptosis of Rat Mesangial Cells* , 2000, The Journal of Biological Chemistry.
[36] M. Benito,et al. p38 Mitogen-Activated Protein Kinase Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Rat Fetal Brown Adipocytes. , 2000, Endocrinology.
[37] M. Benito,et al. Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner. , 1998, Experimental cell research.
[38] J. Stuart,et al. Superoxide activates mitochondrial uncoupling proteins , 2002, Nature.
[39] M. Benito,et al. Activation of caspases occurs downstream from radical oxygen species production, Bcl‐xL down‐regulation, and early cytochrome C release in apoptosis induced by transforming growth factor β in rat fetal hepatocytes , 2001, Hepatology.
[40] C. Patterson,et al. Postischemic Recovery of Contractile Function is Impaired in SOD2+/− but Not SOD1+/− Mouse Hearts , 2002, Circulation.
[41] B. Burgering,et al. Cell cycle and death control: long live Forkheads. , 2002, Trends in biochemical sciences.
[42] G. Thomas,et al. MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways , 1991, Nature.
[43] M. Benito,et al. Reactive oxygen species (ROS) mediates the mitochondrial‐dependent apoptosis induced by transforming growth factor ß in fetal hepatocytes , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[44] Xiangdong Wu,et al. Hydrogen Peroxide Generated during Cellular Insulin Stimulation Is Integral to Activation of the Distal Insulin Signaling Cascade in 3T3-L1 Adipocytes* , 2001, The Journal of Biological Chemistry.
[45] M. Benito,et al. Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture. , 1989, Biochemical and biophysical research communications.
[46] Michael S Avidan,et al. Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2 , 2002, Science.
[47] U. Shankavaram,et al. Activation of cJun NH2-terminal kinase/stress-activated protein kinase by insulin. , 1996, Biochemistry.
[48] T. Gardner,et al. Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3* , 2001, The Journal of Biological Chemistry.
[49] A. Perl,et al. Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling. , 1999, Journal of immunology.
[50] N. Ahn,et al. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation , 1997, Molecular and cellular biology.
[51] A. Gingras,et al. The target of rapamycin (TOR) proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[52] A. Nègre-Salvayre,et al. A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[53] Sten Orrenius,et al. A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis1 , 2002, The Journal of Immunology.
[54] D. Accili,et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. , 2003, Developmental cell.
[55] D. Ricquier,et al. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. , 2000, The Biochemical journal.
[56] M. Benito,et al. Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway , 2002, Oncogene.
[57] S. Rehnmark,et al. Ambient Temperature Regulation of Apoptosis in Brown Adipose Tissue , 1998, The Journal of Biological Chemistry.