The vicious circle of UHRF1 down‐regulation and KEAP1/NRF2/HO‐1 pathway impairment promotes oxidative stress‐induced endothelial cell apoptosis in diabetes

Oxidative stress is recognized as a key factor in the induction of endothelial dysfunction in diabetes. However, the specific mechanisms have not been fully elucidated. We herein hypothesized that ubiquitin‐like containing PHD and RING finger domains 1 (UHRF1) might have a role in oxidative stress‐induced endothelial cell (EC) apoptosis in diabetes.

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