论文信息 - Hepatic Intra-Arterial Chemotherapy (HIAC) of High Dose Mitomycin and Epirubicin Combined with Caval Chemofiltration Versus Prolonged Low Doses in Liver Metastases from Colorectal Cancer: a Prospective Randomized Clinical Study

Hepatic Intra-Arterial Chemotherapy (HIAC) of High Dose Mitomycin and Epirubicin Combined with Caval Chemofiltration Versus Prolonged Low Doses in Liver Metastases from Colorectal Cancer: a Prospective Randomized Clinical Study

Summary A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).

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