Development, Optimization, and Scale-Up of Process Parameters: Tablet Compression

Publisher Summary Compressing pharmaceutical tablets is one of the most efficient processes for producing a single dose of medication. Good granulation is important for compressing quality tablets. A proper tablet granulation will have good flow, compressibility, and release properties. Tablet compression tooling is also responsible for the success of a tableting program. Internationally there are two recognized standards for tablet compression tooling, the “TSM” and the “EU” standards. Both TSM and EU standards identify the physical tool configuration for B and D type tablet compression tools, and their critical dimensions and associated tolerances ensure tablet quality. New technology continues to introduce innovative tool configurations in the effort to provide better efficiency of tablet press speed, product yield, cleaning, and safety. In 1997, IMA introduced a line of unique tablet presses called the IMA Comprima. The IMA Comprima models use an innovative approach with tool design and granulation delivery. These models feed the granulation through the die table, taking advantage of the centrifugal force created by the rotating turret for a rapid and uniform die fill. The most recent innovation with tablet press and tooling technology is developed by Fette GmbH, located in Schwarzenbek, Germany.

[1]  J. C. Cunningham,et al.  Theoretical estimation of dwell and consolidation times in rotary tablet machines , 1992 .

[2]  P. Rue,et al.  Time‐dependent deformation of some direct compression excipients * , 1978, The Journal of pharmacy and pharmacology.

[3]  R. Rowe,et al.  THE INFLUENCE OF PRECOMPRESSION PRESSURE ON CAPPING , 1982 .

[4]  P. York,et al.  An investigation of the effect of the punch velocity on the compaction properties of ibuprofen , 1993 .

[5]  N. Armstrong,et al.  THE EFFECT OF MACHINE SPEED ON THE COMPACTION OF SOME DIRECTLY COMPRESSIBLE TABLET DILUENTS , 1985 .

[6]  N A Armstrong,et al.  The Effect of Machine Speed on the Consolidation of Four Directly Compressible Tablet Diluents , 1989, The Journal of pharmacy and pharmacology.

[7]  H. Leuenberger,et al.  Effect of compression speed on the relationship between normalised solid fraction and mechanical properties of compacts , 1989 .

[8]  J. Newton,et al.  Effect of particle size and speed of compaction on density changes in tablets of crystalline and spray-dried lactose. , 1971, Journal of pharmaceutical sciences.

[9]  M. H. Rubinstein,et al.  A comparative investigation of compression simulators , 1989 .

[10]  M. H. Rubinstein,et al.  The effect of rate of force application on the properties of microcrystalline cellulose and dibasic calcium phosphate mixtures , 1991 .

[11]  M. H. Rubinstein,et al.  An investigation into the capping of paracetamol at increasing speeds of compression , 1991 .

[12]  Changquan Calvin Sun,et al.  Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. , 2005, Journal of pharmaceutical sciences.

[13]  E G Rippie,et al.  Viscoelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and postcompression periods. , 1981, Journal of pharmaceutical sciences.

[14]  R. J. Oates,et al.  Peak Offset Times as an Indication of Stress Relaxation During Tableting on a Rotary Tablet Press * , 1991, The Journal of pharmacy and pharmacology.

[15]  M. Jiménez-Castellanos,et al.  Effect of compression speed and pressure on the physical characteristics of maltodextrin tablets. , 1998, Drug Development and Industrial Pharmacy.

[16]  R. Rowe,et al.  The effect of the relationship between punch velocity and particle size on the compaction behaviour of materials with varying deformation mechanisms , 1986, The Journal of pharmacy and pharmacology.

[17]  N. A. Armstrong,et al.  Time-dependent factors involved in powder compression and tablet manufacture , 1989 .

[18]  K. Marshall,et al.  Use of a Compaction Simulator System in Tabletting Research , 1989 .

[19]  R C Rowe,et al.  The effect of punch velocity on the compaction of a variety of materials , 1985, The Journal of pharmacy and pharmacology.