Machine Learning for Medical Image Reconstruction

Obtaining magnetic resonance images (MRI) with high resolution and generating quantitative image-based biomarkers for assessing tissue biochemistry is crucial in clinical and research applications. However, acquiring quantitative biomarkers requires high signal-to-noise ratio (SNR), which is at odds with high-resolution in MRI, especially in a single rapid sequence. In this paper, we demonstrate how superresolution (SR) can be utilized to maintain adequate SNR for accurate quantification of the T2 relaxation time biomarker, while simultaneously generating high-resolution images. We compare the efficacy of resolution enhancement using metrics such as peak SNR and structural similarity. We assess accuracy of cartilage T2 relaxation times by comparing against a standard reference method. Our evaluation suggests that SR can successfully maintain high-resolution and generate accurate biomarkers for accelerating MRI scans and enhancing the value of clinical and research MRI.

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