Genome‐wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations—significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group

Previous studies have shown that in addition to environmental influences, type 2 diabetes mellitus (T2DM) has a strong genetic component. The goal of the current study is to identify regions of linkage for T2DM in ethnically diverse populations.

[1]  David Cohen,et al.  African Americans , 2021, Race Talk in a Mexican Cantina.

[2]  C. Hanis,et al.  Genome-Wide Linkage and Admixture Mapping of Type 2 Diabetes in African American Families From the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort , 2009, Diabetes.

[3]  M. McCarthy,et al.  Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes , 2008, Nature Genetics.

[4]  M. McCarthy,et al.  Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy. , 2007, Trends in pharmacological sciences.

[5]  E. Rampersaud,et al.  Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish , 2007, Diabetes.

[6]  Ying Sun,et al.  Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies , 2007, Diabetes.

[7]  T. Frayling.  Genome–wide association studies provide new insights into type 2 diabetes aetiology , 2007, Nature Reviews Genetics.

[8]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[9]  Marcia M. Nizzari,et al.  Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , 2007, Science.

[10]  R. Elston,et al.  Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations , 2007, Diabetes.

[11]  Tom R. Gaunt,et al.  Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease , 2007, Human Genetics.

[12]  K. Silver,et al.  Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects , 2006, BMC Medical Genetics.

[13]  P. B. Jensen,et al.  The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  K. Silver,et al.  The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. , 2005, Diabetes.

[15]  R. Elston,et al.  The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. , 2005, Journal of diabetes and its complications.

[16]  J. Pankow,et al.  Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study. , 2004, Diabetes.

[17]  Carl D Langefeld,et al.  A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q. , 2004, Diabetes.

[18]  Donald W. Bowden,et al.  A Genome-Wide Scan for Type 2 Diabetes in African-American Families Reveals Evidence for a Locus on Chromosome 6 q , 2004 .

[19]  M. McCarthy,et al.  Growing evidence for diabetes susceptibility genes from genome scan data , 2003, Current diabetes reports.

[20]  T. Hansen,et al.  A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity. , 2003, Diabetes.

[21]  M. Wagner,et al.  Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24. , 2003, Diabetes.

[22]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[23]  F. Mennicken,et al.  Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system , 2002, Journal of Chemical Neuroanatomy.

[24]  S. Kalra,et al.  Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods , 2002, Peptides.

[25]  P. Wilson,et al.  A Genome-Wide Scan for Loci Linked to Plasma Levels of Glucose and HbA1c in a Community-Based Sample of Caucasian Pedigrees: The Framingham Offspring Study , 2002 .

[26]  M. Stern.  The search for type 2 diabetes susceptibility genes using whole‐genome scans: an epidemiologist's perspective , 2002, Diabetes/metabolism research and reviews.

[27]  M. McCarthy,et al.  Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. , 2002, American journal of human genetics.

[28]  P. Wilson,et al.  A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study. , 2002, Diabetes.

[29]  G. Abecasis,et al.  Merlin—rapid analysis of dense genetic maps using sparse gene flow trees , 2002, Nature Genetics.

[30]  R Foxon,et al.  A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. , 2001, American journal of human genetics.

[31]  M. Luo,et al.  A genome-wide search for Type II diabetes susceptibility genes in Chinese Hans , 2001, Diabetologia.

[32]  C. Bogardus,et al.  Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians. , 2001, Biochimica et biophysica acta.

[33]  C. Lindgren,et al.  A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11. , 2001, Diabetes.

[34]  C. Dina,et al.  Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. , 2000, American journal of human genetics.

[35]  G. Abecasis,et al.  Pedigree tests of transmission disequilibrium , 2000, European Journal of Human Genetics.

[36]  J. Weber,et al.  Genomewide search for type 2 diabetes susceptibility genes in four American populations. , 2000, American journal of human genetics.

[37]  K. Madden,et al.  The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping , 1999, Cytogenetic and Genome Research.

[38]  S. Rich,et al.  Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q. , 1999, Diabetes.

[39]  M. Leppert,et al.  A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. , 1999, Diabetes.

[40]  B. Zinman,et al.  Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers , 1999, Journal of Human Genetics.

[41]  D. Duffy,et al.  Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. , 1998, Diabetes.

[42]  M. Ehm,et al.  An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. , 1998, American journal of human genetics.

[43]  M. Ehm,et al.  An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. , 1998, The Journal of clinical investigation.

[44]  N J Cox,et al.  Allele-sharing models: LOD scores and accurate linkage tests. , 1997, American journal of human genetics.

[45]  S. Rich,et al.  Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy , 1997, Diabetes.

[46]  P. Goodfellow,et al.  Empirical genomewide significance levels established by whole genome simulations , 1997, Genetic epidemiology.

[47]  T. Hansen,et al.  Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) , 1996, Nature.

[48]  M. McCarthy,et al.  Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families , 1996, Nature Genetics.

[49]  P. O'Connell,et al.  Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. , 1996, Genome research.

[50]  E. Lander,et al.  Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results , 1995, Nature Genetics.

[51]  M. Kendall.  Statistical Methods for Research Workers , 1937, Nature.