Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor /c‐Met/survivin regulated by P53/P21

[1]  Dimitris Kletsas,et al.  Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing , 2016, Nature Cell Biology.

[2]  Lu Gao,et al.  Hepatic stellate cell promoted hepatoma cell invasion via the HGF/c-Met signaling pathway regulated by p53 , 2016, Cell cycle.

[3]  Stephen T. C. Wong,et al.  EMT is not required for lung metastasis but contributes to chemoresistance , 2015, Nature.

[4]  V. LeBleu,et al.  EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer , 2015, Nature.

[5]  Stephen T. C. Wong,et al.  EMT is not required for lung metastasis but contributes to chemoresistance , 2016 .

[6]  J. Mann,et al.  The role of pancreatic stellate cells in pancreatic cancer. , 2015, Surgical oncology.

[7]  M. Bouvet,et al.  Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis. , 2015, Anticancer research.

[8]  Eun Mi Kim,et al.  Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion , 2014, EMBO reports.

[9]  S. Pothula,et al.  The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer. , 2014, Carcinogenesis.

[10]  S. Hughes,et al.  c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer. , 2014, World journal of gastroenterology.

[11]  R. Roesler,et al.  PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines , 2014, Investigational New Drugs.

[12]  Haiyang Guo,et al.  Chemokine receptor CXCR2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damage , 2013, Aging cell.

[13]  Dhiraj Yadav,et al.  The epidemiology of pancreatitis and pancreatic cancer. , 2013, Gastroenterology.

[14]  S. Pandol,et al.  A starring role for stellate cells in the pancreatic cancer microenvironment. , 2013, Gastroenterology.

[15]  A. Zhu,et al.  Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma , 2013, Clinical Cancer Research.

[16]  D. Ichikawa,et al.  HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells. , 2013, International journal of oncology.

[17]  R. Langer,et al.  Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. , 2013, Cancer cell.

[18]  K. Vousden,et al.  p53 mutations in cancer , 2013, Nature Cell Biology.

[19]  Derek S. Chan,et al.  The Pancreas Cancer Microenvironment , 2012, Clinical Cancer Research.

[20]  Adrian O'Dowd,et al.  Only women with symptoms need to have their breast implants removed, says government , 2012, BMJ : British Medical Journal.

[21]  C. Prives,et al.  p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation , 2011, Proceedings of the National Academy of Sciences.

[22]  Weihong Wang,et al.  Survivin and pancreatic cancer. , 2011, World journal of clinical oncology.

[23]  Karen H. Vousden,et al.  p53 and its mutants in tumor cell migration and invasion , 2011, The Journal of cell biology.

[24]  Toshikazu Nakamura,et al.  Hepatocyte growth factor twenty years on: Much more than a growth factor , 2011, Journal of gastroenterology and hepatology.

[25]  Andrew Menzies,et al.  The patterns and dynamics of genomic instability in metastatic pancreatic cancer , 2010, Nature.

[26]  Augusto Silva,et al.  p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells. , 2009, Experimental cell research.

[27]  A. Pintzas,et al.  Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. , 2009, Biochimica et biophysica acta.

[28]  H. Ford,et al.  Epithelial-mesenchymal transition in development and cancer. , 2009, Future oncology.

[29]  L. Ellisen,et al.  Molecular diagnostics , 2009, Nature Reviews Drug Discovery.

[30]  D. Berger,et al.  The role of the tumor microenvironment in the progression of pancreatic cancer. , 2008, The Journal of surgical research.

[31]  David Goldstein,et al.  Pancreatic stellate cells: partners in crime with pancreatic cancer cells. , 2008, Cancer research.

[32]  M. Shokrgozar,et al.  Effect of hepatocyte growth factor (HGF) on the level of Survivin & XIAP expression in several human cancer cell lines, after treating with DNA damaging agent , 2007, Molecular and Cellular Biochemistry.

[33]  H. Nakshatri,et al.  Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion , 2007, Oncogene.

[34]  M. Guarino Epithelial-mesenchymal transition and tumour invasion. , 2007, The international journal of biochemistry & cell biology.

[35]  D. Bottaro,et al.  Targeting the c-Met signaling pathway in cancer. , 2008, Clinical cancer research : an official journal of the American Association for Cancer Research.

[36]  U. Bhanot,et al.  Survivin Expression in Pancreatic Intraepithelial Neoplasia (PanIN): Steady Increase Along the Developmental Stages of Pancreatic Ductal Adenocarcinoma , 2006, The American journal of surgical pathology.

[37]  Wolfgang Schima,et al.  Pancreatic adenocarcinoma , 2006, European Radiology.

[38]  T. Kawabe,et al.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. , 2005, Cancer research.

[39]  Myung Ah Lee,et al.  Survivin expression and its clinical significance in pancreatic cancer , 2005, BMC Cancer.

[40]  M. Torbenson,et al.  Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation , 2005, International journal of gastrointestinal cancer.

[41]  Eric Wickstrom,et al.  Characterization of mutations and loss of heterozygosity of p53 and K-ras2 in pancreatic cancer cell lines by immobilized polymerase chain reaction , 2003, BMC biotechnology.

[42]  R. Linehan The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer , 2003 .

[43]  D. Altieri Validating survivin as a cancer therapeutic target , 2003, Nature Reviews Cancer.

[44]  Roman Ludwig,et al.  Invasion and metastasis in pancreatic cancer , 2003, Molecular Cancer.

[45]  E. Campo,et al.  p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx , 1997, The Journal of pathology.