Force Sensing by Microrobot on a Chip

In this paper, we discuss a force sensing by microrobot called magnetically driven microtool (MMT) in a microfluidic chip. On-chip force sensor is fabricated by assembling layers to neglect the friction issue and it is actuated by permanent magnets, which supply mN order force to stimulate microorganisms. The displacement is magnified by designing beams on the force sensor and the sensor achieved 100 μN resolutions. We succeeded in on-chip stimulation and evaluation of Pleurosira laevis by developed MMT with force sensing structure.

[1]  Toshio Fukuda,et al.  Local stiffness measurements of C. elegans by buckling nanoprobes inside an Environmental SEM , 2009, 2009 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[2]  I. Shihira-Ishikawa,et al.  Chloroplast assemblage by mechanical stimulation and its intercellular transmission in diatom cells , 1997, Protoplasma.

[3]  Massimiliano Papi,et al.  Evidence of elastic to plastic transition in the zona pellucida of oocytes using atomic force spectroscopy , 2009 .

[4]  F. Arai,et al.  Driving method of microtool by horizontally arranged permanent magnets for single cell manipulation , 2010 .

[5]  Tijani Gharbi,et al.  Measuring the mechanical behaviour of human oocytes with a very simple SU-8 micro-tool , 2008, Biomedical microdevices.

[6]  Vijay Kumar,et al.  Two-dimensional, vision-based μN force sensor for microrobotics , 2009, 2009 IEEE International Conference on Robotics and Automation.

[7]  K. lkuta,et al.  Optical driven master-slave controllable nano-manipulator with real-time force sensing , 2008, 2008 IEEE 21st International Conference on Micro Electro Mechanical Systems.

[8]  Julien M. J. Racca,et al.  A comparison between diatom-based pH inference models using Artificial Neural Networks (ANN), Weighted Averaging (WA) and Weighted Averaging Partial Least Squares (WA-PLS) regressions , 2001 .

[9]  Taisuke Masuda,et al.  On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations. , 2011, Lab on a chip.

[10]  Fan-Gang Tseng,et al.  Mechanical strength and interfacial failure analysis of cantilevered SU-8 microposts , 2003 .

[11]  Bradley J. Nelson,et al.  A bulk microfabricated multi-axis capacitive cellular force sensor using transverse comb drives , 2002 .

[12]  Christofer Hierold,et al.  Fabrication and characterization of folded SU-8 suspensions for MEMS applications , 2006 .

[13]  V. T. Yadugiri Milking diatoms - a new route to sustainable energy , 2009 .

[14]  Durga Madhab Mahapatra,et al.  Milking Diatoms for Sustainable Energy: Biochemical Engineering versus Gasoline-Secreting Diatom Solar Panels , 2009 .

[15]  H. Craighead,et al.  Microfabricated cantilevers for measurement of subcellular and molecular forces , 1998, IEEE Transactions on Biomedical Engineering.

[16]  Luke P. Lee,et al.  Direct force measurements of biomolecular interactions by nanomechanical force gauge , 2005 .

[17]  A. Miyawaki,et al.  Nano-aquarium for dynamic observation of living cells fabricated by femtosecond laser direct writing of photostructurable glass , 2008, Biomedical microdevices.

[18]  F. Arai,et al.  Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip , 2010, Biomedical microdevices.

[19]  S. Koch,et al.  Micromachined piconewton force sensor for biophysics investigations , 2006 .