Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration
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R. Guthke | R. Gebhardt | J. Hengstler | F. Schliess | S. Hoehme | S. Henkel | A. Ghallab | D. Driesch | J. Böttger | M. Pfaff | D. Häussinger | D. Drasdo | S. Zellmer
[1] W. Gerok,et al. Control of the levels of free amino acids in plasma by the liver. , 1965, Biochemische Zeitschrift.
[2] P W Kuchel,et al. The simulation of the urea cycle: correlation of effects due to inborn errors in the catalytic properties of the enzymes with clinical-biochemical observations. , 1977, The Australian journal of experimental biology and medical science.
[3] T. Deuel,et al. Glutamine synthetase from rat liver. Purification, properties, and preparation of specific antisera. , 1978, The Journal of biological chemistry.
[4] S. Heymsfield,et al. Accurate measurement of liver, kidney, and spleen volume and mass by computerized axial tomography. , 1979, Annals of internal medicine.
[5] W. Oldendorf,et al. Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo. , 1980, The American journal of physiology.
[6] J D McGivan,et al. Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria. , 1983, Biochimica et biophysica acta.
[7] D. Häussinger. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. , 1983, European journal of biochemistry.
[8] R. Gebhardt,et al. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. , 1983, The EMBO journal.
[9] Partial purification and properties of rat liver glutaminase. , 1984, The Biochemical journal.
[10] D. Häussinger,et al. Hepatocyte heterogeneity in ammonia metabolism: impairment of glutamine synthesis in CCl4 induced liver cell necrosis with no effect on urea synthesis. , 1984, Chemico-biological interactions.
[11] D. Häussinger,et al. Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease , 1988, European journal of clinical investigation.
[12] A. Moorman,et al. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. , 1992, Enzyme.
[13] A. Moorman,et al. Hepatic glutaminase mRNA is confined to part of the urea cycle domain in the adult rodent liver lobule , 1994, FEBS letters.
[14] Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion--technique and applications. , 1997, Zeitschrift fur Gastroenterologie.
[15] K. Kaneda,et al. Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. , 1999, Seminars in liver disease.
[16] W. Fellenz,et al. Control of acid-base and ammonia homeostasis by the liver , 2004 .
[17] A. Blei. The pathophysiology of brain edema in acute liver failure , 2005, Neurochemistry International.
[18] D. Drasdo,et al. A single-cell-based model of tumor growth in vitro: monolayers and spheroids , 2005, Physical biology.
[19] F. Schliess,et al. Lipopolysaccharide‐induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat , 2005, Hepatology.
[20] F. Schliess,et al. Glutamine metabolism and signaling in the liver. , 2007, Frontiers in bioscience : a journal and virtual library.
[21] D. Häussinger,et al. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver , 2007, Proceedings of the National Academy of Sciences.
[22] F. Gaunitz,et al. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. , 2007, Progress in histochemistry and cytochemistry.
[23] A. Anderson,et al. A Hybrid Multiscale Model of Solid Tumour Growth and Invasion: Evolution and the Microenvironment , 2007 .
[24] D. Drasdo. Center-based Single-cell Models: An Approach to Multi-cellular Organization Based on a Conceptual Analogy to Colloidal Particles , 2007 .
[25] F. Schliess,et al. Pathogenetic mechanisms of hepatic encephalopathy , 2008, Gut.
[26] R. Jalan,et al. Interorgan ammonia trafficking in liver disease , 2009, Metabolic Brain Disease.
[27] Matthias Hermes,et al. Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration , 2010, Proceedings of the National Academy of Sciences.
[28] Stefan Hoehme,et al. A cell-based simulation software for multi-cellular systems , 2010, Bioinform..
[29] A. Henney,et al. The virtual liver: a multidisciplinary, multilevel challenge for systems biology , 2012, Wiley interdisciplinary reviews. Systems biology and medicine.