Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

[1]  N. Gow,et al.  Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. , 2019, Trends in microbiology.

[2]  Joseph W. Jackson,et al.  Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway , 2019, PLoS genetics.

[3]  C. Urban,et al.  Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence , 2018, mBio.

[4]  M. Netea,et al.  Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling , 2018, mBio.

[5]  M. Lionakis,et al.  Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts. , 2018, Annual review of immunology.

[6]  Alison M. Day,et al.  Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs , 2018, mBio.

[7]  N. Gow,et al.  Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans , 2017, Front. Microbiol..

[8]  Matthew S. Graus,et al.  Mannan molecular sub-structures control nanoscale glucan exposure in Candida , 2017, bioRxiv.

[9]  O. Kniemeyer,et al.  Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus , 2017, Antimicrobial Agents and Chemotherapy.

[10]  M. Netea,et al.  Fungal Recognition and Host Defense Mechanisms , 2017, Microbiology spectrum.

[11]  Guanghua Huang,et al.  Global regulatory roles of the cAMP/PKA pathway revealed by phenotypic, transcriptomic and phosphoproteomic analyses in a null mutant of the PKA catalytic subunit in Candida albicans , 2017, Molecular microbiology.

[12]  D. MacCallum,et al.  Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition , 2017, PLoS pathogens.

[13]  N. Gow,et al.  Elevated catalase expression in a fungal pathogen is a double-edged sword of iron , 2017, PLoS pathogens.

[14]  J. Thevelein,et al.  Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae , 2017, Microbial cell.

[15]  L. Cowen,et al.  Stress Adaptation , 2017, Microbiology spectrum.

[16]  D. Moreira Immunology of fungal infections , 2017 .

[17]  Alistair J. P. Brown,et al.  Lactate signalling regulates fungal β-glucan masking and immune evasion , 2016, Nature Microbiology.

[18]  N. Pavelka,et al.  β-glucan Exposure on the Fungal Cell Wall Tightly Correlates with Competitive Fitness of Candida Species in the Mouse Gastrointestinal Tract , 2016, Front. Cell. Infect. Microbiol..

[19]  A. Fusco-Almeida,et al.  Anti-Immune Strategies of Pathogenic Fungi , 2016, Front. Cell. Infect. Microbiol..

[20]  N. Gow,et al.  Interactions of fungal pathogens with phagocytes , 2016, Nature Reviews Microbiology.

[21]  R. Cavicchioli Microbial ecology of Antarctic aquatic systems , 2015, Nature Reviews Microbiology.

[22]  S. Smeekens,et al.  An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. , 2015, Cytokine.

[23]  N. Gow,et al.  Novel insights into host-fungal pathogen interactions derived from live-cell imaging , 2014, Seminars in Immunopathology.

[24]  M. Netea,et al.  Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels , 2014, Trends in microbiology.

[25]  T. Reynolds,et al.  Masking of β(1-3)-Glucan in the Cell Wall of Candida albicans from Detection by Innate Immune Cells Depends on Phosphatidylserine , 2014, Infection and Immunity.

[26]  C. Grebogi,et al.  Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes , 2014, mBio.

[27]  A. Sellam,et al.  Modeling the Transcriptional Regulatory Network That Controls the Early Hypoxic Response in Candida albicans , 2014, Eukaryotic Cell.

[28]  M. Jacobsen,et al.  Stress adaptation in a pathogenic fungus , 2014, Journal of Experimental Biology.

[29]  J. Feldmann,et al.  Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events , 2013, PLoS pathogens.

[30]  J. Latgé,et al.  The RodA Hydrophobin on Aspergillus fumigatus Spores Masks Dectin-1– and Dectin-2–Dependent Responses and Enhances Fungal Survival In Vivo , 2013, The Journal of Immunology.

[31]  Alistair J. P. Brown,et al.  Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1 , 2013, PLoS pathogens.

[32]  N. Gow,et al.  Live-cell Video Microscopy of Fungal Pathogen Phagocytosis , 2013, Journal of visualized experiments : JoVE.

[33]  David W. Denning,et al.  Hidden Killers: Human Fungal Infections , 2012, Science Translational Medicine.

[34]  S. Noble,et al.  Post-Transcriptional Regulation of the Sef1 Transcription Factor Controls the Virulence of Candida albicans in Its Mammalian Host , 2012, PLoS pathogens.

[35]  Gordon D. Brown,et al.  C-type lectin receptors orchestrate antifungal immunity , 2012, Nature Immunology.

[36]  Teresa R. O’Meara,et al.  The Cryptococcus neoformans Capsule: a Sword and a Shield , 2012, Clinical Microbiology Reviews.

[37]  N. Gow,et al.  Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen , 2012, Cellular microbiology.

[38]  S. Brunke,et al.  Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion , 2012, PLoS pathogens.

[39]  Agostinho Carvalho,et al.  Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis , 2012, Cellular and Molecular Immunology.

[40]  K. Sekimizu,et al.  Intestinal Resident Yeast Candida glabrata Requires Cyb2p-Mediated Lactate Assimilation to Adapt in Mouse Intestine , 2011, PloS one.

[41]  B. Tuch,et al.  An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. , 2011, Cell host & microbe.

[42]  Gordon D. Brown Innate antifungal immunity: the key role of phagocytes. , 2011, Annual review of immunology.

[43]  D. MacCallum,et al.  Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans , 2011, Fungal genetics and biology : FG & B.

[44]  S. Smeekens,et al.  The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2. , 2010, International immunology.

[45]  D. Higgins,et al.  Regulation of the Hypoxic Response in Candida albicans , 2010, Eukaryotic Cell.

[46]  Victoria Chen,et al.  Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity , 2010, Nature Genetics.

[47]  M. Netea,et al.  A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions , 2010, The Journal of Biological Chemistry.

[48]  Brice Enjalbert,et al.  Glucose promotes stress resistance in the fungal pathogen Candida albicans. , 2009, Molecular biology of the cell.

[49]  Duncan W. Wilson,et al.  Candida albicans iron acquisition within the host. , 2009, FEMS yeast research.

[50]  Trees Jansen,et al.  Human dectin-1 deficiency and mucocutaneous fungal infections. , 2009, The New England journal of medicine.

[51]  M. Netea,et al.  Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[52]  A. Vercesi,et al.  Goa1p of Candida albicans Localizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence , 2009, Eukaryotic Cell.

[53]  Y. Pilpel,et al.  Adaptive prediction of environmental changes by microorganisms , 2009, Nature.

[54]  N. Gow,et al.  Property Differences among the Four Major Candida albicans Strain Clades , 2009, Eukaryotic Cell.

[55]  K. Kuchler,et al.  Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance , 2009, Molecular microbiology.

[56]  Gerald R. Fink,et al.  Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment , 2008, PLoS pathogens.

[57]  J. Ruland,et al.  Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 , 2007, Nature Immunology.

[58]  W. Goldman,et al.  Histoplasma capsulatum α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor , 2007, Proceedings of the National Academy of Sciences.

[59]  W. Goldman,et al.  Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor. , 2007, Proceedings of the National Academy of Sciences of the United States of America.

[60]  S. Gordon,et al.  Dectin-1 is required for β-glucan recognition and control of fungal infection , 2007, Nature Immunology.

[61]  G. Fink,et al.  A Drug-Sensitive Genetic Network Masks Fungi from the Immune System , 2006, PLoS pathogens.

[62]  Brice Enjalbert,et al.  Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. , 2005, Molecular biology of the cell.

[63]  M. Cornell,et al.  Role of the Hog 1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans , 2006 .

[64]  M. Ramsdale,et al.  Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system. , 2005, Fungal genetics and biology : FG & B.

[65]  S. Noble,et al.  Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans , 2005, Eukaryotic Cell.

[66]  J. Thevelein,et al.  Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1. , 2005, Biochemical Society transactions.

[67]  John Q. Davies,et al.  Isolation and culture of murine macrophages. , 2005, Methods in molecular biology.

[68]  George Newport,et al.  Regulatory networks affected by iron availability in Candida albicans , 2004, Molecular microbiology.

[69]  B. Morgan,et al.  A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. , 2004, Molecular biology of the cell.

[70]  A. Gillum,et al.  Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations , 2004, Molecular and General Genetics MGG.

[71]  C. Sousa Faculty Opinions recommendation of Dectin-1 mediates the biological effects of beta-glucans. , 2003 .

[72]  S. Gordon,et al.  Dectin-1 Mediates the Biological Effects of β-Glucans , 2003, The Journal of experimental medicine.

[73]  Or Kakhlon,et al.  The labile iron pool: characterization, measurement, and participation in cellular processes(1). , 2002, Free radical biology & medicine.

[74]  J. Ernst,et al.  Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans , 2001, Molecular microbiology.

[75]  M. Whiteway,et al.  Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. , 2001, Molecular biology of the cell.

[76]  A. Brown,et al.  NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans , 2001, The EMBO journal.

[77]  A. Mitchell,et al.  Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen Interactions , 2000, Infection and Immunity.

[78]  N. Ramanan,et al.  A high-affinity iron permease essential for Candida albicans virulence. , 2000, Science.

[79]  A. Mitchell,et al.  Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions , 1999, Journal of bacteriology.

[80]  A. Cassone,et al.  The pH of the Host Niche Controls Gene Expression in and Virulence of Candida albicans , 1998, Infection and Immunity.

[81]  C. Nombela,et al.  Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicans. , 1997, Microbiology.

[82]  D. Bagchi,et al.  Oxidative mechanisms in the toxicity of metal ions. , 1995, Free radical biology & medicine.

[83]  D. Irwin,et al.  Isogenic strain construction and gene mapping in Candida albicans. , 1993, Genetics.

[84]  J. Terra,et al.  Sword and Shield , 1992 .

[85]  J. Cummings Short chain fatty acids in the human colon. , 1981, Gut.

[86]  C. d’Enfert,et al.  Human Fungal Infections. , 1951, British medical journal.