Is breast cancer caused by late exposure to a common virus?

Although there are recognized risk factors for breast cancer, its cause is still unknown. It is hypothesized here that breast cancer results from late exposure to a common virus. This hypothesis is investigated by relating the epidemiology of breast cancer to the seroepidemiology of cytomegalovirus, as a surrogate for a breast cancer virus. The hypothesis is consistent with the geographical distribution of breast cancer; a correlation between breast cancer incidence and the percentage of adults who are cytomegalovirus seropositive in various countries was found (Pearson correlation coefficient -0.79). The hypothesis is also consistent with other risk factors for breast cancer, such as age at onset, family history, hormonal factors and migration.

[1]  L. Stanberry,et al.  Preface to the fifth edition , 2014 .

[2]  G. de Thé,et al.  Environmental and dietary risk factors for nasopharyngeal carcinoma: a case-control study in Zangwu County, Guangxi, China. , 1994, British Journal of Cancer.

[3]  B. Henderson,et al.  An epidemiologic study of breast cancer. , 1974, Journal of the National Cancer Institute.

[4]  M. M. Pater,et al.  Oncogenic transformation by human papillomavirus type 16 deoxyribonucleic acid in the presence of progesterone or progestins from oral contraceptives. , 1990, American journal of obstetrics and gynecology.

[5]  M. Ono,et al.  Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D , 1987, Journal of virology.

[6]  M. Okumura,et al.  Prospective study on maternal, intrauterine, and perinatal infections with cytomegalovirus in Japan during 1976–1990 , 1992, Journal of medical virology.

[7]  G. Leogrande.  The epidemiology of childhood cytomegalovirus infections in a large city of southern Italy , 1993, International journal of clinical & laboratory research.

[8]  J. Ferlay,et al.  Cancer Incidence in Five Continents , 1970, Union Internationale Contre Le Cancer / International Union against Cancer.

[9]  S. Urbaniak,et al.  Cytomegalovirus Studies on Blood Donors in North‐East Scotland and a Review of UK Data , 1993, Vox sanguinis.

[10]  C. Lowe,et al.  Maternal age and birth rank of women with breast cancer. , 1980, Journal of the National Cancer Institute.

[11]  S. Leinster,et al.  PARTICLES WITH PROPERTIES OF RETROVIRUSES IN MONOCYTES FROM PATIENTS WITH BREAST CANCER , 1988, The Lancet.

[12]  L. Strong,et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.

[13]  R. A. May,et al.  Acquisition of cytomegalovirus infection from birth to 10 years: a longitudinal serologic study. , 1987, The Journal of pediatrics.

[14]  O. Østerballe,et al.  A PROSPECTIVE STUDY ON THE INCIDENCE AND SIGNIFICANCE OF CONGENITAL CYTOMEGALOVIRUS INFECTION , 1979, Acta paediatrica Scandinavica.

[15]  A. Evans,et al.  The past is prologue: use of serum banks in cancer research. , 1992, Cancer research.

[16]  A. Andersen,et al.  The JANUS serum bank. , 1993, The Science of the total environment.

[17]  N. Day,et al.  The effect of year of birth on the breast cancer age‐incidence curve in Iceland , 1974, International journal of cancer.

[18]  D. Thomas,et al.  Breast cancer in men. , 1993, Epidemiologic reviews.

[19]  D. Trichopoulos,et al.  Birth order and breast cancer risk , 1991, Cancer Causes & Control.

[20]  B. Henderson,et al.  Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. , 1991, British Journal of Cancer.

[21]  S. Adler.  Cytomegalovirus and Child Day Care , 1989 .

[22]  N. Gutensohn,et al.  Childhood social environment and Hodgkin's disease. , 1981, The New England journal of medicine.

[23]  M. Chiaramonte,et al.  Prevalence of cytomegalovirus infection in Italy. , 1991, Epidemiology and infection.

[24]  W. Jarrett.  The Leeuwenhoek Lecture, 1986 - Environmental carcinogens and papillomaviruses in the pathogenesis of cancer , 1987, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[25]  H. Rochefort,et al.  Mouse mammary tumour virus related sequences are present in human DNA. , 1983, Nucleic acids research.

[26]  S. Spiegelman,et al.  RNA-dependent DNA Polymerase Activity in Virus-like Particles isolated from Human Milk , 1971, Nature.

[27]  P. Buell.  Changing incidence of breast cancer in Japanese-American women. , 1973, Journal of the National Cancer Institute.

[28]  A. Rimpelä,et al.  Cancers of affluence: positive social class gradient and rising incidence trend in some cancer forms. , 1987, Social science & medicine.

[29]  R. Axel,et al.  Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[30]  A. Whittemore,et al.  Epidemiology and primary prevention of cancers of the breast, endometrium, and ovary. A brief overview. , 1994, Annals of epidemiology.

[31]  A. Knudson.  Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[32]  G. Carlström,et al.  Virologic Studies on Cytomegalic Inclusion Disease , 1965, Acta paediatrica Scandinavica.

[33]  P. Lee,et al.  Changing seroepidemiological patterns of cytomegalovirus infection in children in Taiwan from 1984 to 1989 , 1992, Journal of medical virology.

[34]  I. Jack,et al.  SERO‐EPIDEMIOLOGICAL STUDY OF CYTOMEGALOVIRUS INFECTIONS IN MELBOURNE CHILDREN AND SOME ADULTS , 1968, The Medical journal of Australia.

[35]  D. Anderson.  Familial versus sporadic breast cancer , 1992, Cancer.

[36]  L. Young,et al.  Epstein-Barr virus persistence and virus-associated tumours , 1994, The Lancet.

[37]  D. van Beers,et al.  Risk factors inducing the persistence of high‐risk genital papillomaviruses in the normal cervix , 1992, Journal of medical virology.

[38]  M. Epstein,et al.  Various forms of Epstein-Barr virus infection in man: established facts and a general concept. , 1973, Lancet.

[39]  E. Delzell,et al.  Epidemiology of Hodgkin's disease. , 1984, Epidemiologic reviews.

[40]  E. Huang,et al.  Seroepidemiology of cytomegalovirus infection among children between the ages of 4 and 12 years in Taiwan , 1992, Journal of medical virology.

[41]  A. Vaidya,et al.  Search for a Human Breast Cancer Virus , 1971, Nature.

[42]  Y. Hinuma,et al.  High incidence of Japanese infants with antibody to a herpes-type virus associated with cultured Burkitt lymphoma cells. , 1969, Japanese journal of microbiology.

[43]  A. Evans,et al.  Prevalence of antibodies to Epstein-Barr virus and cytomegalovirus in sera from a group of children in the People's Republic of China. , 1986, The Journal of infectious diseases.

[44]  S. Mitrani‐Rosenbaum,et al.  Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical carcinoma cells. , 1989, The Journal of general virology.

[45]  H. Adami,et al.  Breast-feeding and breast cancer in the offspring. , 1993, British Journal of Cancer.

[46]  J L Kelsey,et al.  Breast cancer: magnitude of the problem and descriptive epidemiology. , 1993, Epidemiologic reviews.

[47]  A M Nomura,et al.  Migration patterns and breast cancer risk in Asian-American women. , 1993, Journal of the National Cancer Institute.

[48]  A. Levine,et al.  The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. , 1994, British Journal of Cancer.

[49]  Adel A. F. Mahmoud,et al.  Tropical and Geographical Medicine , 1984 .

[50]  G. Grindlay,et al.  Prophylactic and therapeutic vaccination against a mucosal papillomavirus. , 1993, The Journal of general virology.

[51]  C. Hutto,et al.  Epidemiology of cytomegalovirus infections in young children: day care vs. home care. , 1985, Pediatric infectious disease.

[52]  G. Lenoir,et al.  Infections due to the human herpesviruses in southern India: a seroepidemiological survey. , 1986, International journal of epidemiology.

[53]  S. Karjalainen,et al.  Patients treated in hospital for infectious mononucleosis and risk of cancer. , 1993, Scandinavian journal of infectious diseases.

[54]  J. O'grady,et al.  Epstein-Barr virus in Hodgkin's disease and site of origin of tumour , 1994, The Lancet.

[55]  R. Heath,et al.  Seroprevalence of antibodies to human herpesviruses in England and Hong Kong , 1994, Journal of medical virology.

[56]  M. Ho,et al.  Epidemiology of cytomegalovirus infections. , 1990, Reviews of infectious diseases.

[57]  D. Cohen,et al.  Ethnic and gender differences in the prevalence of anti-cytomegalovirus antibodies among young adults in Israel. , 1993, International journal of epidemiology.

[58]  L. Bernstein,et al.  Endogenous hormones and breast cancer risk. , 1993, Epidemiologic reviews.

[59]  G. Cloud,et al.  Changes in the epidemiology of cytomegalovirus. , 1990, Advances in experimental medicine and biology.

[60]  G. Hems,et al.  Breast cancer rates in populations of single women. , 1975, British Journal of Cancer.

[61]  D. Ward,et al.  Widespread presence of histologically occult cytomegalovirus. , 1984, Human pathology.