P300, probability, and the three-tone paradigm.

The effects of stimulus probability on P300 from a 3-tone paradigm were examined in two experiments. Experiment 1 manipulated the probability of the non-target tone as 0.10, 0.45, or 0.80, while the target tone probability was always 0.10. Experiment 2 manipulated the probability of 3 tones as 0.10, 0.30, or 0.60, with one of the infrequent tones assigned as the target in each condition. Subjects were required to press a button in response to the target stimulus in both experiments. The results indicated that the P300 to the target and the non-target were both affected by the probability of the eliciting stimulus, such that component amplitude was inversely related to probability; no reliable P300 latency effects were found. Target tones elicited larger P300 amplitude than the non-target tones at the same probability. The findings suggest that probability effects on P300 amplitude are independent of responding to a specific target stimulus and are discussed with reference to the clinical utility of the 3-tone paradigm.

[1]  J. Polich,et al.  Meta-analysis of P300 normative aging studies. , 1996, Psychophysiology.

[2]  J. Polich,et al.  Cognitive and biological determinants of P300: an integrative review , 1995, Biological Psychology.

[3]  J. Polich,et al.  P300, probability, and interstimulus interval. , 1990, Psychophysiology.

[4]  John Polich,et al.  Cognitive Brain Potentials , 1993 .

[5]  Gavin S. Lew,et al.  P300, habituation, and response mode , 1993, Physiology & Behavior.

[6]  C. C. Wood,et al.  Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. , 1985, Electroencephalography and clinical neurophysiology.

[7]  J. Polich,et al.  P300 from one-, two-, and three-stimulus auditory paradigms. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[8]  R. Knight.  Decreased response to novel stimuli after prefrontal lesions in man. , 1984, Electroencephalography and clinical neurophysiology.

[9]  H. J. Eysenck,et al.  Advances in psychophysiology: J.R. Jennings, P.K. Ackles & M.G.H. Coles (Eds) Vol.5 (1993).320 pp. £42.50 (hardback). ISBN 185302 191 1 , 1994 .

[10]  G Fein,et al.  P300 latency variability in normal elderly: effects of paradigm and measurement technique. , 1989, Electroencephalography and clinical neurophysiology.

[11]  G. McCarthy,et al.  Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. , 1977, Science.

[12]  E. Donchin,et al.  On quantifying surprise: the variation of event-related potentials with subjective probability. , 1977, Psychophysiology.

[13]  C. Grillon,et al.  P300 assessment of anxiety effects on processing novel stimuli. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[14]  John Polich,et al.  Response mode and P300 from auditory stimuli , 1987, Biological Psychology.

[15]  E Courchesne,et al.  Effects of rare non-target stimuli on brain electrophysiological activity and performance. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[16]  George R. Mangun,et al.  New Developments in Event-Related Potentials , 1993 .

[17]  A Pfefferbaum,et al.  Clinical application of the P3 component of event-related potentials. I. Normal aging. , 1984, Electroencephalography and clinical neurophysiology.

[18]  Michael C. Doyle,et al.  Cognitive brain potentials in a three-stimulus auditory “oddball” task after closed head injury , 1993, Neuropsychologia.

[19]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[20]  D Friedman,et al.  Age-related changes in scalp topography to novel and target stimuli. , 1993, Psychophysiology.

[21]  R. Knight.  Aging decreases auditory event-related potentials to unexpected stimuli in humans , 1987, Neurobiology of Aging.

[22]  Effect of task decision on P300. , 1992, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[23]  N. Squires,et al.  Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. , 1975, Electroencephalography and clinical neurophysiology.

[24]  John Polich,et al.  P300 in Clinical Applications: Meaning, Method, and Measurement , 1991 .

[25]  R. Knight,et al.  P300 generation by novel somatosensory stimuli. , 1991, Electroencephalography and clinical neurophysiology.

[26]  E Courchesne,et al.  Changes in P3 waves with event repetition: long-term effects on scalp distribution and amplitude. , 1978, Electroencephalography and clinical neurophysiology.

[27]  Ray Johnson.  For Distinguished Early Career Contribution to Psychophysiology: Award Address, 1985 , 1986 .

[28]  J. Polich,et al.  Task difficulty, probability, and inter-stimulus interval as determinants of P300 from auditory stimuli. , 1987, Electroencephalography and clinical neurophysiology.

[29]  J. Polich,et al.  Attention, probability, and task demands as determinants of P300 latency from auditory stimuli. , 1986, Electroencephalography and clinical neurophysiology.

[30]  J. Polich,et al.  P300 from a single auditory stimulus. , 1994, Electroencephalography and clinical neurophysiology.

[31]  E. Donchin,et al.  Is the P300 component a manifestation of context updating? , 1988, Behavioral and Brain Sciences.

[32]  R. Johnson.  A triarchic model of P300 amplitude. , 1986, Psychophysiology.

[33]  J. Polich,et al.  P300 topography and modality effects from a single-stimulus paradigm. , 1996, Psychophysiology.

[34]  Ernst Fernando Lopes Da Silva Niedermeyer,et al.  Electroencephalography, basic principles, clinical applications, and related fields , 1982 .

[35]  R. E. Dustman,et al.  Long latency components of the visually evoked potential in man: effects of aging. , 1980, Experimental aging research.

[36]  R Galambos,et al.  Autism: processing of novel auditory information assessed by event-related brain potentials. , 1984, Electroencephalography and clinical neurophysiology.

[37]  E. Donchin,et al.  Cognitive Psychophysiology and Human Information Processing , 1986 .

[38]  J. Polich.  Habituation of P300 from auditory stimuli , 1989, Psychobiology.

[39]  Steven A. Hillyard,et al.  The effect of stimulus deviation on P3 waves to easily recognized stimuli , 1978, Neuropsychologia.

[40]  G. V. Simpson,et al.  ERP amplitude and scalp distribution to target and novel events: effects of temporal order in young, middle-aged and older adults. , 1994, Brain research. Cognitive brain research.

[41]  E. Donchin,et al.  On the dependence of P300 latency on stimulus evaluation processes. , 1984, Psychophysiology.

[42]  E. Donchin,et al.  Psychophysiology : systems, processes, and applications , 1987 .

[43]  R Verleger,et al.  The waltzing oddball. , 1991, Psychophysiology.

[44]  J. Ford,et al.  Age-related changes in auditory event-related potentials. , 1980, Electroencephalography and clinical neurophysiology.

[45]  R. Johnson,et al.  On the neural generators of the P300 component of the event-related potential. , 2007, Psychophysiology.