Hippocampal morphology and distinguishing late-onset from early-onset elderly depression.

OBJECTIVE Despite evidence for hippocampal abnormalities in elderly depression, it is unknown whether these changes are regionally specific. This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated. METHOD With high-resolution magnetic resonance imaging, hippocampal morphology was compared among elderly patients with early- (N=24) and late-onset (N=22) depression and comparison subjects (N=34). Regional structural abnormalities were identified by comparing distances, measured from homologous hippocampal surface points to the central core of each individual's hippocampal surface model, between groups. RESULTS Hippocampal volumes differed between depressed patients and comparison subjects but not between patients with early- and late-onset depression. However, statistical mapping results showed that regional surface contractions were significantly pronounced in late- compared to early-onset depression in the anterior of the subiculum and lateral posterior of the CA1 subfield in the left hemisphere. Significant shape differences were observed bilaterally in anterior CA1-CA3 subfields and the subiculum in patients in relation to comparison subjects. These results were similar when each disease group was separately compared to comparison subjects. Hippocampal surface contractions significantly correlated with memory measures among late- but not early-onset depressed patients or comparison subjects. CONCLUSIONS More pronounced regional volume deficits and their associations with memory in late-onset depression may suggest that these patients are more likely to develop cognitive impairment over time than individuals with early-onset depression. Mapping regional hippocampal abnormalities and their cognitive correlates may help guide research in defining risk profiles and treatment strategies.

[1]  David Loewenstein,et al.  Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. , 2006, Archives of general psychiatry.

[2]  Kiralee M. Hayashi,et al.  Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps. , 2006, Archives of neurology.

[3]  V. Pankratz,et al.  Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study. , 2006, Archives of neurology.

[4]  Michael A Rapp,et al.  Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. , 2006, Archives of general psychiatry.

[5]  B. Lebowitz,et al.  Late-Life Depression: A Model for Medical Classification , 2005, Biological Psychiatry.

[6]  Warren D Taylor,et al.  Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. , 2005, Archives of general psychiatry.

[7]  A. Green,et al.  Depression and the Risk of Alzheimer Disease , 2005, Epidemiology.

[8]  Philip B. Ward,et al.  Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression , 2005, British Journal of Psychiatry.

[9]  James C. Overholser,et al.  Cellular changes in the postmortem hippocampus in major depression , 2004, Biological Psychiatry.

[10]  Arthur W Toga,et al.  Localizing gray matter deficits in late-onset depression using computational cortical pattern matching methods. , 2004, The American journal of psychiatry.

[11]  Anil Gholkar,et al.  A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. , 2004, The American journal of psychiatry.

[12]  Paul M. Thompson,et al.  Mapping hippocampal and ventricular change in Alzheimer disease , 2004, NeuroImage.

[13]  Paul M. Thompson,et al.  Regional specificity of hippocampal volume reductions in first-episode schizophrenia , 2004, NeuroImage.

[14]  Peter Zwanzger,et al.  Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. , 2004, Archives of general psychiatry.

[15]  Arthur W Toga,et al.  Mapping brain size and cortical gray matter changes in elderly depression , 2003, Biological Psychiatry.

[16]  Arthur W Toga,et al.  Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. , 2004, The American journal of psychiatry.

[17]  Michael I. Miller,et al.  Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging☆ , 2003, NeuroImage.

[18]  M. Miller,et al.  High-dimensional mapping of the hippocampus in depression. , 2003, The American journal of psychiatry.

[19]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[20]  J. O'Brien,et al.  Is late onset depression a prodrome to dementia? , 2002, International journal of geriatric psychiatry.

[21]  J. Lyness.  The Cerebrovascular Model of Depression in Late Life , 2002, CNS Spectrums.

[22]  James T Becker,et al.  Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. , 2002, The American journal of psychiatry.

[23]  M A Mintun,et al.  The hippocampus and depression , 2002, European Psychiatry.

[24]  B. Pollock,et al.  Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression. , 2001, The American journal of psychiatry.

[25]  James R MacFall,et al.  Hippocampal volume in geriatric depression , 2000, Biological Psychiatry.

[26]  M. Witter,et al.  Anatomical Organization of the Parahippocampal‐Hippocampal Network , 2000, Annals of the New York Academy of Sciences.

[27]  G. Rosoklija,et al.  Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings. , 2000, Archives of general psychiatry.

[28]  N C Andreasen,et al.  A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy , 2000, Hippocampus.

[29]  Yvette I. Sheline,et al.  Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression , 1999, The Journal of Neuroscience.

[30]  M Ashtari,et al.  Hippocampal/amygdala volumes in geriatric depression , 1999, Psychological Medicine.

[31]  G. Bruce Pike,et al.  Standing-wave and RF penetration artifacts caused by elliptic geometry: an electrodynamic analysis of MRI , 1998, IEEE Transactions on Medical Imaging.

[32]  J C Mazziotta,et al.  Automated image registration: II. Intersubject validation of linear and nonlinear models. , 1998, Journal of computer assisted tomography.

[33]  H. Duvernoy,et al.  The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI , 1997 .

[34]  K. Krishnan,et al.  MRI-defined vascular depression. , 1997, The American journal of psychiatry.

[35]  E. Gillard,et al.  MRI and neuropsychological differences in early- and late-life-onset geriatric depression , 1996, Neurology.

[36]  R. Mayeux,et al.  Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. , 1996, Archives of general psychiatry.

[37]  Arthur W. Toga,et al.  A Probabilistic Atlas of the Human Brain: Theory and Rationale for Its Development The International Consortium for Brain Mapping (ICBM) , 1995, NeuroImage.

[38]  H. Barbas,et al.  Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey , 1995, Hippocampus.

[39]  D. Kupfer,et al.  Age at Onset or Late-Life Depression: A Research Agenda Report of a MacArthur Foundation-NIMH Workshop. , 1994, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[40]  A. Rey,et al.  Translations of excerpts from Andre Rey"s Psychological examination of traumatic encephalopathy and P. A. Osterrieth"s The Complex Figure Copy Test.. , 1993 .

[41]  H. Akil,et al.  Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[42]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[43]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.