Autonomic control of cardiac chronotropic function in man as a function of age: assessment by power spectral analysis of heart rate variability.

The analysis of age-related features of the autonomic heart rate control during various periods of postnatal human ontogenesis is presented. The study was performed in 354 apparently healthy individuals of either sex, ranging in age from 3 months to 89 years. The method of spectral analysis of heart rate variability was used. We demonstrated different ratios between the sympathetic and the parasympathetic influences upon heart rate control in relation to age. In infancy and after 50 years, there is a prevalence of the sympathetic activity against a background of weak parasympathetic activity. In early years, the prevalence of the parasympathetic activity is observed at a sufficiently high sympathetic activity level.

[1]  D. Adam,et al.  Assessment of autonomic function in humans by heart rate spectral analysis. , 1985, The American journal of physiology.

[2]  R. Kaminski,et al.  Sympathetic unit activity associated with Mayer waves in the spinal dog. , 1970, The American journal of physiology.

[3]  K Koizumi,et al.  Effect of cardiac vagal and sympathetic nerve activity on heart rate in rhythmic fluctuations. , 1985, Journal of the autonomic nervous system.

[4]  M. Turiel,et al.  Power Spectral Analysis of Heart Rate and Arterial Pressure Variabilities as a Marker of Sympatho‐Vagal Interaction in Man and Conscious Dog , 1986, Circulation research.

[5]  E. Lakatta,et al.  Why cardiovascular function may decline with age. , 1987, Geriatrics.

[6]  J. Chalmers,et al.  Relative importance of sympathetic nerves and of circulating adrenaline and vasopressin in mediating hypertension after lesions of the caudal ventrolateral medulla in the rat. , 1986, Journal of hypertension.

[7]  F Heydenreich,et al.  Contributions of sympathetic and vagal mechanisms to the genesis of heart rate fluctuations during orthostatic load: a spectral analysis. , 1987, Journal of the autonomic nervous system.

[8]  B. Sayers,et al.  Analysis of heart rate variability. , 1973, Ergonomics.

[9]  J D Best,et al.  Differential changes of autonomic nervous system function with age in man. , 1983, The American journal of medicine.

[10]  R. Lefkowitz,et al.  The Impact of Aging on Adrenergic Receptor Function: Clinical and Biochemical Aspects , 1985, Journal of the American Geriatrics Society.

[11]  G. Varoneckas,et al.  Components of the heart rhythm power spectrum in wakefulness and individual sleep stages. , 1986, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[12]  G. Kelliher,et al.  Changes in vagal activity and response to muscarinic receptor agonists with age. , 1980, Journal of gerontology.

[13]  E. Lakatta.  Age-related alterations in the cardiovascular response to adrenergic mediated stress. , 1980, Federation proceedings.

[14]  R. Cohen,et al.  Sudden Infant Death Syndrome: Abnormalities in Short Term Fluctuations in Heart Rate and Respiratory Activity , 1984, Pediatric Research.

[15]  K. Eckoldt,et al.  Sinus arrhythmia and heart rate in hypertonic disease. , 1976, Advances in cardiology.

[16]  R Peto,et al.  Effect of Age and High Blood Pressure on Barorefiex Sensitivity in Man , 1971, Circulation research.

[17]  G. Preiss,et al.  Patterns of sympathetic neuron activity associated with Mayer waves. , 1974, The American journal of physiology.

[18]  D. Shannon,et al.  Aging of modulation of heart rate. , 1987, The American journal of physiology.

[19]  J. Jennings,et al.  Does aging differentially reduce heart rate variability related to respiration? , 1984, Experimental aging research.

[20]  A. D. Jose,et al.  Effect of combined sympathetic and parasympathetic blockade on heart rate and cardiac function in man. , 1966, The American journal of cardiology.

[21]  P G Katona,et al.  Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. , 1975, Journal of applied physiology.

[22]  R. Wicks,et al.  Spectral analysis of heart rate indicates reduced baroreceptor-related heart rate variability in elderly persons. , 1988, Journal of gerontology.

[23]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[24]  Adrian J. Wilson,et al.  Analysis of Heart Rate and Respiratory Patterns in Sudden Infant Death Syndrome Victims and Control Infants , 1986, Pediatric Research.

[25]  H. Jongsma,et al.  On the Intrinsic Cardiac Rhythm , 1982 .