Analyser-based phase contrast image reconstruction using geometrical optics.

Analyser-based phase contrast imaging can provide radiographs of exceptional contrast at high resolution (<100 microm), whilst quantitative phase and attenuation information can be extracted using just two images when the approximations of geometrical optics are satisfied. Analytical phase retrieval can be performed by fitting the analyser rocking curve with a symmetric Pearson type VII function. The Pearson VII function provided at least a 10% better fit to experimentally measured rocking curves than linear or Gaussian functions. A test phantom, a hollow nylon cylinder, was imaged at 20 keV using a Si(1 1 1) analyser at the ELETTRA synchrotron radiation facility. Our phase retrieval method yielded a more accurate object reconstruction than methods based on a linear fit to the rocking curve. Where reconstructions failed to map expected values, calculations of the Takagi number permitted distinction between the violation of the geometrical optics conditions and the failure of curve fitting procedures. The need for synchronized object/detector translation stages was removed by using a large, divergent beam and imaging the object in segments. Our image acquisition and reconstruction procedure enables quantitative phase retrieval for systems with a divergent source and accounts for imperfections in the analyser.

[1]  N. Galatsanos,et al.  Multiple-image radiography. , 2003, Physics in medicine and biology.

[2]  Miles N. Wernick,et al.  Extraction of extinction, refraction and absorption properties in diffraction enhanced imaging , 2003 .

[3]  Timur E. Gureyev,et al.  Quantitative diffraction-enhanced x-ray imaging of weak objects , 2004 .

[4]  Timur E. Gureyev,et al.  Linear systems with slowly varying transfer functions and their application to x-ray phase-contrast imaging , 2004 .

[5]  Luigi Rigon,et al.  Diffraction-enhanced X-ray medical imaging at the ELETTRA synchrotron light source , 2005 .

[6]  A Bravin,et al.  research papers Acta Crystallographica Section A Foundations of , 2006 .

[7]  M. E. Alferieff,et al.  Refraction contrast in X-ray introscopy , 1991 .

[8]  P Suortti,et al.  Medical applications of synchrotron radiation. , 2003, Physics in medicine and biology.

[9]  V. N. Ingal,et al.  X-ray plane-wave topography observation of the phase contrast from a non-crystalline object , 1995 .

[10]  Atsushi Momose,et al.  Biological Imaging by X-ray Phase Tomography Using Diffraction-Enhanced Imaging , 2005 .

[11]  Paola Coan,et al.  Phase-contrast X-ray imaging combining free space propagation and Bragg diffraction. , 2005, Journal of synchrotron radiation.

[12]  D R Dance,et al.  X-ray refraction effects: application to the imaging of biological tissues. , 2003, The British journal of radiology.

[13]  A. Bravin,et al.  Exploiting the x-ray refraction contrast with an analyser: the state of the art , 2003 .

[14]  Bo Liu,et al.  A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues , 2006, Comput. Medical Imaging Graph..

[15]  H. Rubin,et al.  The approximation of symmetric X-ray peaks by Pearson type VII distributions , 1977 .

[16]  William Thomlinson,et al.  Implementation of diffraction-enhanced imaging experiments: at the NSLS and APS , 2000 .

[17]  Timur E. Gureyev,et al.  Regimes of X-ray phase-contrast imaging with perfect crystals , 1997 .

[18]  Anatoly Snigirev,et al.  Phase-contrast X-ray imaging with synchrotron radiation for materials science applications , 2003 .

[19]  Wei Huang,et al.  Computed tomography algorithm based on diffraction-enhanced imaging setup , 2005 .

[20]  I. Orion,et al.  Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method. , 2000, Physics in medicine and biology.

[21]  John R Davis,et al.  A variant on the geometrical optics approximation in diffraction enhanced tomography , 2001 .

[22]  E. Pisano,et al.  Diffraction enhanced x-ray imaging. , 1997, Physics in medicine and biology.

[23]  T. Gureyev,et al.  Phase retrieval using coherent imaging systems with linear transfer functions , 2004 .

[24]  A. Authier Dynamical theory of x-ray diffraction , 2001 .

[25]  E Castelli,et al.  Mammography with synchrotron radiation: phase-detection techniques. , 2000, Radiology.

[26]  Paola Coan,et al.  A method to extract quantitative information in analyzer-based x-ray phase contrast imaging , 2003 .

[27]  Refraction-angle resolution of diffraction enhanced imaging. , 2006, Physics in medicine and biology.

[28]  S. Wilkins,et al.  Phase-contrast imaging of weakly absorbing materials using hard X-rays , 1995, Nature.

[29]  Zhong Zhong,et al.  Measurement of image contrast using diffraction enhanced imaging. , 2003, Physics in medicine and biology.

[30]  E. Förster,et al.  Double crystal diffractometry for the characterization of targets for laser fusion experiments , 1980 .